Matches in SemOpenAlex for { <https://semopenalex.org/work/W2930119673> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2930119673 endingPage "610" @default.
- W2930119673 startingPage "606" @default.
- W2930119673 abstract "Abstract: RAS-associated autoimmune leukoproliferative disease (RALD) is a recently described noninfectious and nonmalignant clinical syndrome characterized by autoimmune disorders, massive splenomegaly, modest lymphadenopathy, and monocytosis. On the molecular level, RALD is defined by somatic mutations of either NRAS or KRAS gene in a subset of hematopoietic cells. To date, there is a dearth of well-documented histopathologic description of cutaneous involvement by RALD in the literature. In the current case report, a 43-year-old female patient with a history of RALD presented with clinical pictures of sepsis and an erythematous rash in the left lower extremity. Histologic examination revealed a dense perivascular and interstitial infiltrate of immature myeloid cells admixed with scattered neutrophils involving the dermis and subcutaneous adipose tissue, imparting a panniculitis-like histologic pictures. There was a strong angiocentric propensity of the immature hematopoietic cells as well as extensive extravasation of red blood cells, even in the subcutaneous adipose tissue. Immunohistochemically, the immature hematopoietic cells were positive for CD43, CD4, and CD68, but negative for CD34, CD117, and myeloperoxidase. Overall, the histologic and cytologic findings were highly reminiscent of histiocytoid Sweet syndrome. Review of the English literature revealed cutaneous involvements by RALD only in patients with KRAS mutation compared with none of its NRAS counterparts. However, larger clinicopathologic studies on cutaneous involvement by RALD are warranted. The term “RALD cutis” with its histologic and molecular features is suggested to serve as a potential groundwork for future studies of this rare phenomenon." @default.
- W2930119673 created "2019-04-11" @default.
- W2930119673 creator A5054165565 @default.
- W2930119673 creator A5063971464 @default.
- W2930119673 creator A5081759686 @default.
- W2930119673 date "2019-08-01" @default.
- W2930119673 modified "2023-09-28" @default.
- W2930119673 title "Superficial and Deep Cutaneous Involvement by RAS-Associated Autoimmunne Leukoproliferative Disease (RALD Cutis): A Histologic Mimicker of Histiocytoid Sweet Syndrome" @default.
- W2930119673 cites W1969636647 @default.
- W2930119673 cites W1971202489 @default.
- W2930119673 cites W1973020307 @default.
- W2930119673 cites W1989350633 @default.
- W2930119673 cites W2047210789 @default.
- W2930119673 cites W2072494162 @default.
- W2930119673 cites W2073697154 @default.
- W2930119673 cites W2073770580 @default.
- W2930119673 cites W2086614915 @default.
- W2930119673 cites W2088649576 @default.
- W2930119673 cites W2109446357 @default.
- W2930119673 cites W2328927634 @default.
- W2930119673 cites W2346571134 @default.
- W2930119673 cites W2601779515 @default.
- W2930119673 cites W2612790400 @default.
- W2930119673 cites W2808207348 @default.
- W2930119673 cites W4232777855 @default.
- W2930119673 doi "https://doi.org/10.1097/dad.0000000000001332" @default.
- W2930119673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31335417" @default.
- W2930119673 hasPublicationYear "2019" @default.
- W2930119673 type Work @default.
- W2930119673 sameAs 2930119673 @default.
- W2930119673 citedByCount "4" @default.
- W2930119673 countsByYear W29301196732020 @default.
- W2930119673 countsByYear W29301196732021 @default.
- W2930119673 crossrefType "journal-article" @default.
- W2930119673 hasAuthorship W2930119673A5054165565 @default.
- W2930119673 hasAuthorship W2930119673A5063971464 @default.
- W2930119673 hasAuthorship W2930119673A5081759686 @default.
- W2930119673 hasConcept C10205521 @default.
- W2930119673 hasConcept C121608353 @default.
- W2930119673 hasConcept C126322002 @default.
- W2930119673 hasConcept C142724271 @default.
- W2930119673 hasConcept C196166836 @default.
- W2930119673 hasConcept C203014093 @default.
- W2930119673 hasConcept C21790070 @default.
- W2930119673 hasConcept C2776839831 @default.
- W2930119673 hasConcept C2778934254 @default.
- W2930119673 hasConcept C2781187634 @default.
- W2930119673 hasConcept C28328180 @default.
- W2930119673 hasConcept C526805850 @default.
- W2930119673 hasConcept C54355233 @default.
- W2930119673 hasConcept C553184892 @default.
- W2930119673 hasConcept C71924100 @default.
- W2930119673 hasConcept C86803240 @default.
- W2930119673 hasConceptScore W2930119673C10205521 @default.
- W2930119673 hasConceptScore W2930119673C121608353 @default.
- W2930119673 hasConceptScore W2930119673C126322002 @default.
- W2930119673 hasConceptScore W2930119673C142724271 @default.
- W2930119673 hasConceptScore W2930119673C196166836 @default.
- W2930119673 hasConceptScore W2930119673C203014093 @default.
- W2930119673 hasConceptScore W2930119673C21790070 @default.
- W2930119673 hasConceptScore W2930119673C2776839831 @default.
- W2930119673 hasConceptScore W2930119673C2778934254 @default.
- W2930119673 hasConceptScore W2930119673C2781187634 @default.
- W2930119673 hasConceptScore W2930119673C28328180 @default.
- W2930119673 hasConceptScore W2930119673C526805850 @default.
- W2930119673 hasConceptScore W2930119673C54355233 @default.
- W2930119673 hasConceptScore W2930119673C553184892 @default.
- W2930119673 hasConceptScore W2930119673C71924100 @default.
- W2930119673 hasConceptScore W2930119673C86803240 @default.
- W2930119673 hasIssue "8" @default.
- W2930119673 hasLocation W29301196731 @default.
- W2930119673 hasLocation W29301196732 @default.
- W2930119673 hasOpenAccess W2930119673 @default.
- W2930119673 hasPrimaryLocation W29301196731 @default.
- W2930119673 hasRelatedWork W1992085819 @default.
- W2930119673 hasRelatedWork W2186453396 @default.
- W2930119673 hasRelatedWork W2347762466 @default.
- W2930119673 hasRelatedWork W2366427024 @default.
- W2930119673 hasRelatedWork W2372522834 @default.
- W2930119673 hasRelatedWork W2375403474 @default.
- W2930119673 hasRelatedWork W2376601074 @default.
- W2930119673 hasRelatedWork W2376726681 @default.
- W2930119673 hasRelatedWork W2378005971 @default.
- W2930119673 hasRelatedWork W3003294112 @default.
- W2930119673 hasVolume "41" @default.
- W2930119673 isParatext "false" @default.
- W2930119673 isRetracted "false" @default.
- W2930119673 magId "2930119673" @default.
- W2930119673 workType "article" @default.