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- W2930256426 abstract "The pathogenesis of vulvar squamous neoplasia has 2 pathways: human papillomavirus (HPV)-dependent and HPV-independent. The HPV-dependent pathway in the vulva follows the same progression as HPV-dependent lesions elsewhere in the gynecologic tract—HPV infection results in high-grade squamous intraepithelial lesion with subsequent progression to basaloid squamous cell carcinoma. The HPV-independent pathway is more complex, with a variety of precursor lesions and molecular alterations. Although the most recognized form of HPV-independent vulvar lesion is differentiated vulvar intraepithelial neoplasia, recent explorations have elucidated new precursors. This review provides an update on HPV-independent risk factors and precursor lesions for squamous cell carcinoma of the vulva." @default.
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- W2930256426 date "2019-06-01" @default.
- W2930256426 modified "2023-09-25" @default.
- W2930256426 title "Human Papillomavirus–Independent Squamous Lesions of the Vulva" @default.
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- W2930256426 doi "https://doi.org/10.1016/j.path.2019.01.001" @default.
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