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• W2930530313 abstract "Objective: The aim of the study was to compare impact on survival after resection of primary tumors (PTs) after peptide receptor radionuclide therapy (PRRT). Background: PRRT is a highly effective therapeutic option to treat locally advanced or metastatic neuroendocrine neoplasms (NENs). Methods: We retrospectively analyzed the data of 889 patients with advanced NEN (G1-G3, stage IV) treated with at least 1 cycle of PRRT. In 486 of 889 patients (55%, group 1), PT had been removed before PRRT. Group 2 constituted 403 patients (45%) with no prior PT resection. Progression-free survival (PFS) and overall survival (OS) was determined by 68Ga SSTR-PET/CT in all patients applying RECIST and EORTC. Results: Most patients had their PT in pancreas (n = 335; 38%) and small intestine (n = 284; 32%). Both groups received a mean of 4 cycles of PRRT (P = 0.835) with a mean cumulative administered radioactivity of 21.6 ± 11.7 versus 22.2 ± 11.2 GBq (P = 0.407). Median OS in group 1 was 134.0 months [confidence interval (CI): 118–147], whereas OS in group 2 was 67.0 months (CI: 60–80; hazard ratio 2.79); P < 0.001. Likewise, the median progression-free survival after first PRRT was longer in group 1 with 18.0 (CI: 15–20) months as compared to group 2 with 14.0 (CI: 15–18; hazard ratio 1.21) months; P = 0.012. Conclusions: A previous resection of the PT before PRRT provides a significant survival benefit in patients with NENs stage IV." @default.
• W2930530313 created "2019-04-11" @default.
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• W2930530313 date "2019-03-04" @default.
• W2930530313 modified "2023-10-04" @default.
• W2930530313 title "Prior Resection of the Primary Tumor Prolongs Survival After Peptide Receptor Radionuclide Therapy of Advanced Neuroendocrine Neoplasms" @default.
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• W2930530313 doi "https://doi.org/10.1097/sla.0000000000003237" @default.
• W2930530313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33030849" @default.
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