FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2930710952> ?p ?o ?g. }

• W2930710952 abstract "Abstract A specific family of proteins that participate in epigenetic regulation is the bromodomain (BRD) family of proteins. In this work, we aimed to explore the expression of the BRD family at a transcriptomic level in breast cancer, and its association with patient survival. mRNA level data from normal breast and tumor tissues were extracted from public datasets. Gene set enrichment analysis (GSEA) was performed to identify relevant biological functions. The KM Plotter Online tool was used to evaluate the relationship between the presence of different genes and patient clinical outcome. mRNA level data from HER2+ breast cancer patients sensible and resistant to trastuzumab were also evaluated. The BRD family was an enriched function. In HER2 positive tumors the combined analyses of BRD2, BAZ1A, TRIM33 and ZMYND8 showed a detrimental relapse free survival (RFS). Similarly, the combined analysis of BRD2, BAZ1A, PHIP, TRIM33, KMT2A, ASH1L, PBRM1, correlated with an extremely poor overall survival (OS). The prognosis was confirmed using an independent dataset from TCGA. Finally, no relation between expression of BRD genes and response to trastuzumab was observed in the HER2 population. Upregulation of some BRD genes is associated with detrimental outcome in HER2 positive tumors, regardless trastuzumab treatment." @default.
• W2930710952 created "2019-04-11" @default.
• W2930710952 creator A5017029931 @default.
• W2930710952 creator A5023340072 @default.
• W2930710952 creator A5037253399 @default.
• W2930710952 creator A5042534464 @default.
• W2930710952 creator A5045773639 @default.
• W2930710952 creator A5054921200 @default.
• W2930710952 creator A5059666666 @default.
• W2930710952 creator A5074810713 @default.
• W2930710952 date "2019-04-05" @default.
• W2930710952 modified "2023-10-16" @default.
• W2930710952 title "Mapping Bromodomains in breast cancer and association with clinical outcome" @default.
• W2930710952 cites W1625510017 @default.
• W2930710952 cites W1974266360 @default.
• W2930710952 cites W1983619854 @default.
• W2930710952 cites W1994552886 @default.
• W2930710952 cites W2003872705 @default.
• W2930710952 cites W2017289276 @default.
• W2930710952 cites W2017909805 @default.
• W2930710952 cites W2039998866 @default.
• W2930710952 cites W2041535798 @default.
• W2930710952 cites W2057742567 @default.
• W2930710952 cites W2085934079 @default.
• W2930710952 cites W2087826750 @default.
• W2930710952 cites W2096283457 @default.
• W2930710952 cites W2102803803 @default.
• W2930710952 cites W2150954652 @default.
• W2930710952 cites W2179093278 @default.
• W2930710952 cites W2226721679 @default.
• W2930710952 cites W2299219969 @default.
• W2930710952 cites W2402636472 @default.
• W2930710952 cites W2411070120 @default.
• W2930710952 cites W2498228861 @default.
• W2930710952 cites W2571278114 @default.
• W2930710952 cites W2572535868 @default.
• W2930710952 cites W2593741942 @default.
• W2930710952 cites W4230236971 @default.
• W2930710952 doi "https://doi.org/10.1038/s41598-019-41934-3" @default.
• W2930710952 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6450889" @default.
• W2930710952 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30952871" @default.
• W2930710952 hasPublicationYear "2019" @default.
• W2930710952 type Work @default.
• W2930710952 sameAs 2930710952 @default.
• W2930710952 citedByCount "10" @default.
• W2930710952 countsByYear W29307109522019 @default.
• W2930710952 countsByYear W29307109522020 @default.
• W2930710952 countsByYear W29307109522021 @default.
• W2930710952 countsByYear W29307109522022 @default.
• W2930710952 countsByYear W29307109522023 @default.
• W2930710952 crossrefType "journal-article" @default.
• W2930710952 hasAuthorship W2930710952A5017029931 @default.
• W2930710952 hasAuthorship W2930710952A5023340072 @default.
• W2930710952 hasAuthorship W2930710952A5037253399 @default.
• W2930710952 hasAuthorship W2930710952A5042534464 @default.
• W2930710952 hasAuthorship W2930710952A5045773639 @default.
• W2930710952 hasAuthorship W2930710952A5054921200 @default.
• W2930710952 hasAuthorship W2930710952A5059666666 @default.
• W2930710952 hasAuthorship W2930710952A5074810713 @default.
• W2930710952 hasBestOaLocation W29307109521 @default.
• W2930710952 hasConcept C104317684 @default.
• W2930710952 hasConcept C121608353 @default.
• W2930710952 hasConcept C126322002 @default.
• W2930710952 hasConcept C127561419 @default.
• W2930710952 hasConcept C135763542 @default.
• W2930710952 hasConcept C143998085 @default.
• W2930710952 hasConcept C150194340 @default.
• W2930710952 hasConcept C153209595 @default.
• W2930710952 hasConcept C162317418 @default.
• W2930710952 hasConcept C2779786085 @default.
• W2930710952 hasConcept C41091548 @default.
• W2930710952 hasConcept C502942594 @default.
• W2930710952 hasConcept C530470458 @default.
• W2930710952 hasConcept C54355233 @default.
• W2930710952 hasConcept C60644358 @default.
• W2930710952 hasConcept C71924100 @default.
• W2930710952 hasConcept C74401373 @default.
• W2930710952 hasConcept C86803240 @default.
• W2930710952 hasConceptScore W2930710952C104317684 @default.
• W2930710952 hasConceptScore W2930710952C121608353 @default.
• W2930710952 hasConceptScore W2930710952C126322002 @default.
• W2930710952 hasConceptScore W2930710952C127561419 @default.
• W2930710952 hasConceptScore W2930710952C135763542 @default.
• W2930710952 hasConceptScore W2930710952C143998085 @default.
• W2930710952 hasConceptScore W2930710952C150194340 @default.
• W2930710952 hasConceptScore W2930710952C153209595 @default.
• W2930710952 hasConceptScore W2930710952C162317418 @default.
• W2930710952 hasConceptScore W2930710952C2779786085 @default.
• W2930710952 hasConceptScore W2930710952C41091548 @default.
• W2930710952 hasConceptScore W2930710952C502942594 @default.
• W2930710952 hasConceptScore W2930710952C530470458 @default.
• W2930710952 hasConceptScore W2930710952C54355233 @default.
• W2930710952 hasConceptScore W2930710952C60644358 @default.
• W2930710952 hasConceptScore W2930710952C71924100 @default.
• W2930710952 hasConceptScore W2930710952C74401373 @default.
• W2930710952 hasConceptScore W2930710952C86803240 @default.
• W2930710952 hasFunder F4320334923 @default.
• W2930710952 hasIssue "1" @default.
• W2930710952 hasLocation W29307109521 @default.
• W2930710952 hasLocation W29307109522 @default.

• next