FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2930714906> ?p ?o ?g. }

• W2930714906 endingPage "3259" @default.
• W2930714906 startingPage "3248" @default.
• W2930714906 abstract "The pathogenesis of endocarditis is not well understood resulting in unsuccessful attempts at prevention. Clinical observations suggest that Staphylococcus aureus infects either damaged or inflamed heart valves. Using a newly developed endocarditis mouse model, we therefore studied the initial adhesion of S. aureus in both risk states.Using 3D confocal microscopy, we examined the adhesion of fluorescent S. aureus to murine aortic valves. To mimic different risk states we either damaged the valves with a surgically placed catheter or simulated valve inflammation by local endothelium activation. We used von Willebrand factor (VWF) gene-deficient mice, induced platelet and fibrinogen depletion and used several S. aureus mutant strains to investigate the contribution of both host and bacterial factors in early bacterial adhesion. Both cardiac valve damage and inflammation predisposed to endocarditis, but by distinct mechanisms. Following valve damage, S. aureus adhered directly to VWF and fibrin, deposited on the damaged valve. This was mediated by Sortase A-dependent adhesins such as VWF-binding protein and Clumping factor A. Platelets did not contribute. In contrast, upon cardiac valve inflammation, widespread endothelial activation led to endothelial cell-bound VWF release. This recruited large amounts of platelets, capturing S. aureus to the valve surface. Here, neither fibrinogen, nor Sortase A were essential.Cardiac valve damage and inflammation predispose to S. aureus endocarditis via distinct mechanisms. These findings may have important implications for the development of new preventive strategies, as some interventions might be effective in one risk state, but not in the other." @default.
• W2930714906 created "2019-04-11" @default.
• W2930714906 creator A5003253172 @default.
• W2930714906 creator A5005368537 @default.
• W2930714906 creator A5005399851 @default.
• W2930714906 creator A5006329944 @default.
• W2930714906 creator A5011196347 @default.
• W2930714906 creator A5011938070 @default.
• W2930714906 creator A5025928709 @default.
• W2930714906 creator A5044812020 @default.
• W2930714906 creator A5046989298 @default.
• W2930714906 creator A5053044262 @default.
• W2930714906 creator A5053368690 @default.
• W2930714906 creator A5057802451 @default.
• W2930714906 creator A5061589261 @default.
• W2930714906 creator A5072840972 @default.
• W2930714906 creator A5073747183 @default.
• W2930714906 creator A5083683183 @default.
• W2930714906 date "2019-04-03" @default.
• W2930714906 modified "2023-10-18" @default.
• W2930714906 title "<i>Staphylococcus aureus</i> endocarditis: distinct mechanisms of bacterial adhesion to damaged and inflamed heart valves" @default.
• W2930714906 cites W1525181991 @default.
• W2930714906 cites W1531026153 @default.
• W2930714906 cites W1920355337 @default.
• W2930714906 cites W1968617592 @default.
• W2930714906 cites W2005749758 @default.
• W2930714906 cites W2010693564 @default.
• W2930714906 cites W2048787993 @default.
• W2930714906 cites W2055664469 @default.
• W2930714906 cites W2088137635 @default.
• W2930714906 cites W2113664933 @default.
• W2930714906 cites W2146095795 @default.
• W2930714906 cites W2148912816 @default.
• W2930714906 cites W2150738582 @default.
• W2930714906 cites W2226826308 @default.
• W2930714906 cites W4210970544 @default.
• W2930714906 doi "https://doi.org/10.1093/eurheartj/ehz175" @default.
• W2930714906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30945735" @default.
• W2930714906 hasPublicationYear "2019" @default.
• W2930714906 type Work @default.
• W2930714906 sameAs 2930714906 @default.
• W2930714906 citedByCount "64" @default.
• W2930714906 countsByYear W29307149062019 @default.
• W2930714906 countsByYear W29307149062020 @default.
• W2930714906 countsByYear W29307149062021 @default.
• W2930714906 countsByYear W29307149062022 @default.
• W2930714906 countsByYear W29307149062023 @default.
• W2930714906 crossrefType "journal-article" @default.
• W2930714906 hasAuthorship W2930714906A5003253172 @default.
• W2930714906 hasAuthorship W2930714906A5005368537 @default.
• W2930714906 hasAuthorship W2930714906A5005399851 @default.
• W2930714906 hasAuthorship W2930714906A5006329944 @default.
• W2930714906 hasAuthorship W2930714906A5011196347 @default.
• W2930714906 hasAuthorship W2930714906A5011938070 @default.
• W2930714906 hasAuthorship W2930714906A5025928709 @default.
• W2930714906 hasAuthorship W2930714906A5044812020 @default.
• W2930714906 hasAuthorship W2930714906A5046989298 @default.
• W2930714906 hasAuthorship W2930714906A5053044262 @default.
• W2930714906 hasAuthorship W2930714906A5053368690 @default.
• W2930714906 hasAuthorship W2930714906A5057802451 @default.
• W2930714906 hasAuthorship W2930714906A5061589261 @default.
• W2930714906 hasAuthorship W2930714906A5072840972 @default.
• W2930714906 hasAuthorship W2930714906A5073747183 @default.
• W2930714906 hasAuthorship W2930714906A5083683183 @default.
• W2930714906 hasBestOaLocation W29307149062 @default.
• W2930714906 hasConcept C104317684 @default.
• W2930714906 hasConcept C126322002 @default.
• W2930714906 hasConcept C164705383 @default.
• W2930714906 hasConcept C178790620 @default.
• W2930714906 hasConcept C179470777 @default.
• W2930714906 hasConcept C185592680 @default.
• W2930714906 hasConcept C203014093 @default.
• W2930714906 hasConcept C2775872228 @default.
• W2930714906 hasConcept C2776914184 @default.
• W2930714906 hasConcept C2776992346 @default.
• W2930714906 hasConcept C2777334864 @default.
• W2930714906 hasConcept C2778839769 @default.
• W2930714906 hasConcept C2779036427 @default.
• W2930714906 hasConcept C2779394231 @default.
• W2930714906 hasConcept C2779489039 @default.
• W2930714906 hasConcept C2780176578 @default.
• W2930714906 hasConcept C2780972559 @default.
• W2930714906 hasConcept C523546767 @default.
• W2930714906 hasConcept C54173615 @default.
• W2930714906 hasConcept C54355233 @default.
• W2930714906 hasConcept C55493867 @default.
• W2930714906 hasConcept C60987743 @default.
• W2930714906 hasConcept C71924100 @default.
• W2930714906 hasConcept C84416704 @default.
• W2930714906 hasConcept C86803240 @default.
• W2930714906 hasConcept C89423630 @default.
• W2930714906 hasConcept C89560881 @default.
• W2930714906 hasConceptScore W2930714906C104317684 @default.
• W2930714906 hasConceptScore W2930714906C126322002 @default.
• W2930714906 hasConceptScore W2930714906C164705383 @default.
• W2930714906 hasConceptScore W2930714906C178790620 @default.
• W2930714906 hasConceptScore W2930714906C179470777 @default.
• W2930714906 hasConceptScore W2930714906C185592680 @default.

• next