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• W2930723622 startingPage "1249" @default.
• W2930723622 abstract "Regulated activation of the cytokine TGF-β by integrins αvβ6 and αvβ8 expressed on keratinocytes is required for residence of epidermal-resident memory T cells, but whether skin-derived signals also affect recirculating memory cells in the skin remains unclear. Here, we show that after resolution of skin vaccinia virus (VV) infection, antigen-specific circulating memory CD8+ T cells migrated into skin. In mice lacking αvβ6 and αvβ8 integrins (Itgb6−/−Itgb8fl/fl-K14-cre), the absence of epidermal-activated TGF-β resulted in a gradual loss of E- or P-selectin-binding central and peripheral memory populations, which were rescued when skin entry was inhibited. Skin recirculating memory cells were required for optimal host defense against skin VV infection. These data demonstrate that skin migration can persist after resolution of local skin infection and that the cytokine environment within this nonlymphoid tissue shapes the differentiation state and persistence of the central and peripheral memory-T-cell pool." @default.
• W2930723622 created "2019-04-11" @default.
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• W2930723622 date "2019-05-01" @default.
• W2930723622 modified "2023-10-16" @default.
• W2930723622 title "Keratinocyte-Mediated Activation of the Cytokine TGF-β Maintains Skin Recirculating Memory CD8+ T Cells" @default.
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• W2930723622 doi "https://doi.org/10.1016/j.immuni.2019.03.002" @default.
• W2930723622 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6531326" @default.
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