Matches in SemOpenAlex for { <https://semopenalex.org/work/W2930961156> ?p ?o ?g. }
- W2930961156 endingPage "897" @default.
- W2930961156 startingPage "877" @default.
- W2930961156 abstract "A combination of biochemical, biophysical and biological techniques was used to study calf thymus DNA interaction with newly synthesized 7-MEOTA-tacrine thiourea 12–17 and urea heterodimers 18–22, and to measure interference with type I and II topoisomerases. Their biological profile was also inspected in vitro on the HL-60 cell line using different flow cytometric techniques (cell cycle distribution, detection of mitochondrial membrane potential dissipation, and analysis of metabolic activity/viability). The compounds exhibited a profound inhibitory effect on topoisomerase activity (e.g. compound 22 inhibited type I topoisomerase at 1 µM concentration). The treatment of HL-60 cells with the studied compounds showed inhibition of cell growth especially with hybrids containing thiourea (14–17) and urea moieties (21 and 22). Moreover, treatment of human dermal fibroblasts with the studied compounds did not indicate significant cytotoxicity. The observed results suggest beneficial selectivity of the heterodimers as potential drugs to target cancer cells." @default.
- W2930961156 created "2019-04-11" @default.
- W2930961156 creator A5004161945 @default.
- W2930961156 creator A5011323357 @default.
- W2930961156 creator A5013238937 @default.
- W2930961156 creator A5016761392 @default.
- W2930961156 creator A5019962548 @default.
- W2930961156 creator A5020286203 @default.
- W2930961156 creator A5029293106 @default.
- W2930961156 creator A5031419076 @default.
- W2930961156 creator A5035352729 @default.
- W2930961156 creator A5038375683 @default.
- W2930961156 creator A5053329693 @default.
- W2930961156 creator A5053921766 @default.
- W2930961156 creator A5062168572 @default.
- W2930961156 creator A5064116973 @default.
- W2930961156 creator A5066903927 @default.
- W2930961156 creator A5081885555 @default.
- W2930961156 creator A5087115321 @default.
- W2930961156 date "2019-01-01" @default.
- W2930961156 modified "2023-10-17" @default.
- W2930961156 title "<i>In vitro</i> investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers" @default.
- W2930961156 cites W1945332708 @default.
- W2930961156 cites W1952429233 @default.
- W2930961156 cites W1965861059 @default.
- W2930961156 cites W1965910452 @default.
- W2930961156 cites W1966596299 @default.
- W2930961156 cites W1967078129 @default.
- W2930961156 cites W1969612501 @default.
- W2930961156 cites W1970015293 @default.
- W2930961156 cites W1971256828 @default.
- W2930961156 cites W1972300483 @default.
- W2930961156 cites W1975361879 @default.
- W2930961156 cites W1978345586 @default.
- W2930961156 cites W1989651677 @default.
- W2930961156 cites W1991131398 @default.
- W2930961156 cites W1994490060 @default.
- W2930961156 cites W1996524234 @default.
- W2930961156 cites W1999164938 @default.
- W2930961156 cites W2000591584 @default.
- W2930961156 cites W2000837493 @default.
- W2930961156 cites W2006343633 @default.
- W2930961156 cites W2008757142 @default.
- W2930961156 cites W2009722630 @default.
- W2930961156 cites W2010511880 @default.
- W2930961156 cites W2010676078 @default.
- W2930961156 cites W2013176372 @default.
- W2930961156 cites W2022153734 @default.
- W2930961156 cites W2031646822 @default.
- W2930961156 cites W2034081127 @default.
- W2930961156 cites W2036754777 @default.
- W2930961156 cites W2038786052 @default.
- W2930961156 cites W2039124321 @default.
- W2930961156 cites W2039322158 @default.
- W2930961156 cites W2039474772 @default.
- W2930961156 cites W2041051519 @default.
- W2930961156 cites W2041061631 @default.
- W2930961156 cites W2047747812 @default.
- W2930961156 cites W2048302866 @default.
- W2930961156 cites W2048813880 @default.
- W2930961156 cites W2056249358 @default.
- W2930961156 cites W2060051891 @default.
- W2930961156 cites W2067878166 @default.
- W2930961156 cites W2069151403 @default.
- W2930961156 cites W2071161708 @default.
- W2930961156 cites W2072497885 @default.
- W2930961156 cites W2074551985 @default.
- W2930961156 cites W2075362384 @default.
- W2930961156 cites W2075749903 @default.
- W2930961156 cites W2078583470 @default.
- W2930961156 cites W2082493113 @default.
- W2930961156 cites W2083992537 @default.
- W2930961156 cites W2088004099 @default.
- W2930961156 cites W2088188015 @default.
- W2930961156 cites W2090133434 @default.
- W2930961156 cites W2093410090 @default.
- W2930961156 cites W2094747148 @default.
- W2930961156 cites W2097786201 @default.
- W2930961156 cites W2111699871 @default.
- W2930961156 cites W2114644061 @default.
- W2930961156 cites W2121322934 @default.
- W2930961156 cites W2121454394 @default.
- W2930961156 cites W2149598176 @default.
- W2930961156 cites W2155335795 @default.
- W2930961156 cites W2155610829 @default.
- W2930961156 cites W2157074499 @default.
- W2930961156 cites W2158576753 @default.
- W2930961156 cites W2159751080 @default.
- W2930961156 cites W2160948762 @default.
- W2930961156 cites W2168244728 @default.
- W2930961156 cites W2236136189 @default.
- W2930961156 cites W2264367524 @default.
- W2930961156 cites W2300515871 @default.
- W2930961156 cites W2319386786 @default.
- W2930961156 cites W2338442196 @default.
- W2930961156 cites W2341196099 @default.
- W2930961156 cites W2343878936 @default.
- W2930961156 cites W2345468031 @default.