FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2931364066> ?p ?o ?g. }

• W2931364066 endingPage "101718" @default.
• W2931364066 startingPage "101718" @default.
• W2931364066 abstract "Classification models based on magnetic resonance imaging (MRI) may aid early diagnosis of frontotemporal dementia (FTD) but have only been applied in established FTD cases. Detection of FTD patients in earlier disease stages, such as presymptomatic mutation carriers, may further advance early diagnosis and treatment. In this study, we aim to distinguish presymptomatic FTD mutation carriers from controls on an individual level using multimodal MRI-based classification. Anatomical MRI, diffusion tensor imaging (DTI) and resting-state functional MRI data were collected in 55 presymptomatic FTD mutation carriers (8 microtubule-associated protein Tau, 35 progranulin, and 12 chromosome 9 open reading frame 72) and 48 familial controls. We calculated grey and white matter density features from anatomical MRI scans, diffusivity features from DTI, and functional connectivity features from resting-state functional MRI. These features were applied in a recently introduced multimodal behavioural variant FTD (bvFTD) classification model, and were subsequently used to train and test unimodal and multimodal carrier-control models. Classification performance was quantified using area under the receiver operator characteristic curves (AUC). The bvFTD model was not able to separate presymptomatic carriers from controls beyond chance level (AUC = 0.582, p = 0.078). In contrast, one unimodal and several multimodal carrier-control models performed significantly better than chance level. The unimodal model included the radial diffusivity feature and had an AUC of 0.642 (p = 0.032). The best multimodal model combined radial diffusivity and white matter density features (AUC = 0.684, p = 0.004). FTD mutation carriers can be separated from controls with a modest AUC even before symptom-onset, using a newly created carrier-control classification model, while this was not possible using a recent bvFTD classification model. A multimodal MRI-based classification score may therefore be a useful biomarker to aid earlier FTD diagnosis. The exclusive selection of white matter features in the best performing model suggests that the earliest FTD-related pathological processes occur in white matter." @default.
• W2931364066 created "2019-04-11" @default.
• W2931364066 creator A5006096323 @default.
• W2931364066 creator A5007363301 @default.
• W2931364066 creator A5037667066 @default.
• W2931364066 creator A5040374514 @default.
• W2931364066 creator A5053874473 @default.
• W2931364066 creator A5055877229 @default.
• W2931364066 creator A5060633478 @default.
• W2931364066 creator A5077645977 @default.
• W2931364066 creator A5083808012 @default.
• W2931364066 creator A5086111072 @default.
• W2931364066 date "2019-01-01" @default.
• W2931364066 modified "2023-10-16" @default.
• W2931364066 title "Single-subject classification of presymptomatic frontotemporal dementia mutation carriers using multimodal MRI" @default.
• W2931364066 cites W1509434847 @default.
• W2931364066 cites W1525938031 @default.
• W2931364066 cites W1546594011 @default.
• W2931364066 cites W1823618591 @default.
• W2931364066 cites W1919284595 @default.
• W2931364066 cites W1965775572 @default.
• W2931364066 cites W1970578687 @default.
• W2931364066 cites W1970914866 @default.
• W2931364066 cites W1971565607 @default.
• W2931364066 cites W1975394589 @default.
• W2931364066 cites W1980773005 @default.
• W2931364066 cites W1983209442 @default.
• W2931364066 cites W1986986092 @default.
• W2931364066 cites W1987274400 @default.
• W2931364066 cites W1989274511 @default.
• W2931364066 cites W2006096283 @default.
• W2931364066 cites W2012367031 @default.
• W2931364066 cites W2015866962 @default.
• W2931364066 cites W2020044743 @default.
• W2931364066 cites W2021422157 @default.
• W2931364066 cites W2024576158 @default.
• W2931364066 cites W2028309433 @default.
• W2931364066 cites W2034517662 @default.
• W2931364066 cites W2040461025 @default.
• W2931364066 cites W2043242347 @default.
• W2931364066 cites W2047095305 @default.
• W2931364066 cites W2047453615 @default.
• W2931364066 cites W2048681279 @default.
• W2931364066 cites W2052644075 @default.
• W2931364066 cites W2065815171 @default.
• W2931364066 cites W2071881327 @default.
• W2931364066 cites W2073906214 @default.
• W2931364066 cites W2080176338 @default.
• W2931364066 cites W2088021832 @default.
• W2931364066 cites W2089940272 @default.
• W2931364066 cites W2094843559 @default.
• W2931364066 cites W2096672020 @default.
• W2931364066 cites W2097360283 @default.
• W2931364066 cites W2097764378 @default.
• W2931364066 cites W2099880194 @default.
• W2931364066 cites W2101334128 @default.
• W2931364066 cites W2102932082 @default.
• W2931364066 cites W2103270909 @default.
• W2931364066 cites W2103717170 @default.
• W2931364066 cites W2106786486 @default.
• W2931364066 cites W2117340355 @default.
• W2931364066 cites W2117621792 @default.
• W2931364066 cites W2121322199 @default.
• W2931364066 cites W2122825543 @default.
• W2931364066 cites W2124263729 @default.
• W2931364066 cites W2128030851 @default.
• W2931364066 cites W2129981926 @default.
• W2931364066 cites W2132555912 @default.
• W2931364066 cites W2138190873 @default.
• W2931364066 cites W2141007997 @default.
• W2931364066 cites W2143460188 @default.
• W2931364066 cites W2147948236 @default.
• W2931364066 cites W2150667092 @default.
• W2931364066 cites W2158698691 @default.
• W2931364066 cites W2160736363 @default.
• W2931364066 cites W2160917765 @default.
• W2931364066 cites W2165360324 @default.
• W2931364066 cites W2168844688 @default.
• W2931364066 cites W2192985207 @default.
• W2931364066 cites W2194005842 @default.
• W2931364066 cites W2223851414 @default.
• W2931364066 cites W2289251924 @default.
• W2931364066 cites W2436762990 @default.
• W2931364066 cites W2470439561 @default.
• W2931364066 cites W2560149596 @default.
• W2931364066 cites W2563086900 @default.
• W2931364066 cites W2572740378 @default.
• W2931364066 cites W2586505479 @default.
• W2931364066 cites W2619097621 @default.
• W2931364066 cites W2619323525 @default.
• W2931364066 cites W2625796101 @default.
• W2931364066 cites W2750650624 @default.
• W2931364066 cites W2766970894 @default.
• W2931364066 cites W2773789615 @default.
• W2931364066 cites W2795077733 @default.
• W2931364066 cites W4235770099 @default.
• W2931364066 cites W4251162813 @default.
• W2931364066 cites W4294541781 @default.

• next