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- W2931657978 abstract "Significance The use of increasingly sophisticated drugs to treat diseases like cancer often requires increasingly sophisticated delivery technologies, where multiple drugs often must be delivered simultaneously and in precise amounts; moreover, many drugs are hydrophobic and cannot be easily delivered. We report a simple and robust process to fabricate nanometer-sized polymersomes that can simultaneously deliver multiple therapeutics, both hydrophobic and hydrophilic, and have significantly improved drug-loading efficiencies over existing methods. We use these polymersomes to deliver a combination of hydrophobic anticancer drugs in a mouse model and see remarkable effectiveness against breast tumors. This work enables the use of previously undeliverable compounds in cancer therapy and forms a foundation for further development in a broad range of biomedical applications." @default.
- W2931657978 created "2019-04-11" @default.
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- W2931657978 date "2019-03-29" @default.
- W2931657978 modified "2023-10-12" @default.
- W2931657978 title "Photothermal-responsive nanosized hybrid polymersome as versatile therapeutics codelivery nanovehicle for effective tumor suppression" @default.
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- W2931657978 doi "https://doi.org/10.1073/pnas.1817251116" @default.
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