FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2931752016> ?p ?o ?g. }

• W2931752016 endingPage "676" @default.
• W2931752016 startingPage "671" @default.
• W2931752016 abstract "Alzheimer’s disease (AD) represents a global problem, with an estimation of the majority of dementia patients in low- and middle-income countries by 2050. Thus, the development of sustainable drugs has attracted much attention in recent years. In light of this, taking inspiration from the HDAC inhibitor vorinostat (1), we develop the first HDAC inhibitors derived from cashew nut shell liquid (CNSL), an inexpensive agro-food waste material. CNSL derivatives 8 and 9 display a HDAC inhibitory profile similar to 1, together with a more promising safety for 9 compared to 1. Moreover, both compounds and particularly 9 were able to effectively modulate glial cell-induced inflammation and to revert the pro-inflammatory phenotype. All these results demonstrate that the use of inexpensive food waste materials could be successfully applied for the development of accessible and sustainable drug candidates for the treatment of AD." @default.
• W2931752016 created "2019-04-11" @default.
• W2931752016 creator A5000518140 @default.
• W2931752016 creator A5001849471 @default.
• W2931752016 creator A5002660712 @default.
• W2931752016 creator A5003943852 @default.
• W2931752016 creator A5011323357 @default.
• W2931752016 creator A5012618073 @default.
• W2931752016 creator A5016266091 @default.
• W2931752016 creator A5024343666 @default.
• W2931752016 creator A5028843194 @default.
• W2931752016 creator A5031707065 @default.
• W2931752016 creator A5038645983 @default.
• W2931752016 creator A5041457152 @default.
• W2931752016 creator A5054083521 @default.
• W2931752016 creator A5069833831 @default.
• W2931752016 creator A5075804512 @default.
• W2931752016 creator A5085277820 @default.
• W2931752016 creator A5090475908 @default.
• W2931752016 date "2019-03-29" @default.
• W2931752016 modified "2023-10-14" @default.
• W2931752016 title "Novel Sustainable-by-Design HDAC Inhibitors for the Treatment of Alzheimer’s Disease" @default.
• W2931752016 cites W1993676790 @default.
• W2931752016 cites W1995678544 @default.
• W2931752016 cites W2010105460 @default.
• W2931752016 cites W2021098795 @default.
• W2931752016 cites W2044000724 @default.
• W2931752016 cites W2063078660 @default.
• W2931752016 cites W2077978004 @default.
• W2931752016 cites W2090054406 @default.
• W2931752016 cites W2116381732 @default.
• W2931752016 cites W2129635356 @default.
• W2931752016 cites W2132351720 @default.
• W2931752016 cites W2146249493 @default.
• W2931752016 cites W2146824244 @default.
• W2931752016 cites W2157020351 @default.
• W2931752016 cites W2167710782 @default.
• W2931752016 cites W2206696478 @default.
• W2931752016 cites W2407468727 @default.
• W2931752016 cites W2491494855 @default.
• W2931752016 cites W2584086915 @default.
• W2931752016 cites W2615166509 @default.
• W2931752016 cites W2622437567 @default.
• W2931752016 cites W2728558285 @default.
• W2931752016 cites W2735906958 @default.
• W2931752016 cites W2738387465 @default.
• W2931752016 cites W2745028397 @default.
• W2931752016 cites W2793294925 @default.
• W2931752016 cites W2799566889 @default.
• W2931752016 cites W2892417862 @default.
• W2931752016 cites W2911866882 @default.
• W2931752016 cites W2918066696 @default.
• W2931752016 doi "https://doi.org/10.1021/acsmedchemlett.9b00071" @default.
• W2931752016 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6466821" @default.
• W2931752016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30996816" @default.
• W2931752016 hasPublicationYear "2019" @default.
• W2931752016 type Work @default.
• W2931752016 sameAs 2931752016 @default.
• W2931752016 citedByCount "19" @default.
• W2931752016 countsByYear W29317520162020 @default.
• W2931752016 countsByYear W29317520162021 @default.
• W2931752016 countsByYear W29317520162022 @default.
• W2931752016 countsByYear W29317520162023 @default.
• W2931752016 crossrefType "journal-article" @default.
• W2931752016 hasAuthorship W2931752016A5000518140 @default.
• W2931752016 hasAuthorship W2931752016A5001849471 @default.
• W2931752016 hasAuthorship W2931752016A5002660712 @default.
• W2931752016 hasAuthorship W2931752016A5003943852 @default.
• W2931752016 hasAuthorship W2931752016A5011323357 @default.
• W2931752016 hasAuthorship W2931752016A5012618073 @default.
• W2931752016 hasAuthorship W2931752016A5016266091 @default.
• W2931752016 hasAuthorship W2931752016A5024343666 @default.
• W2931752016 hasAuthorship W2931752016A5028843194 @default.
• W2931752016 hasAuthorship W2931752016A5031707065 @default.
• W2931752016 hasAuthorship W2931752016A5038645983 @default.
• W2931752016 hasAuthorship W2931752016A5041457152 @default.
• W2931752016 hasAuthorship W2931752016A5054083521 @default.
• W2931752016 hasAuthorship W2931752016A5069833831 @default.
• W2931752016 hasAuthorship W2931752016A5075804512 @default.
• W2931752016 hasAuthorship W2931752016A5085277820 @default.
• W2931752016 hasAuthorship W2931752016A5090475908 @default.
• W2931752016 hasBestOaLocation W29317520162 @default.
• W2931752016 hasConcept C104317684 @default.
• W2931752016 hasConcept C126322002 @default.
• W2931752016 hasConcept C150903083 @default.
• W2931752016 hasConcept C185592680 @default.
• W2931752016 hasConcept C203014093 @default.
• W2931752016 hasConcept C2776262904 @default.
• W2931752016 hasConcept C2776914184 @default.
• W2931752016 hasConcept C2778305200 @default.
• W2931752016 hasConcept C2779134260 @default.
• W2931752016 hasConcept C2779483572 @default.
• W2931752016 hasConcept C2780035454 @default.
• W2931752016 hasConcept C3020017016 @default.
• W2931752016 hasConcept C31903555 @default.
• W2931752016 hasConcept C502032728 @default.
• W2931752016 hasConcept C55493867 @default.
• W2931752016 hasConcept C64927066 @default.

• next