FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2931964518> ?p ?o ?g. }

• W2931964518 abstract "Resistance-associated substitutions (RASs) of hepatitis C virus (HCV) in the NS5A region impair the efficacy of NS5A inhibitors. In this study, we evaluated the characteristics of the novel RASs observed in treatment-failure patients, A92K and a deletion at P32 (P32del), and the susceptibility of viruses with these RASs to various anti-HCV reagents by using JFH-1 based recombinant HCV with NS5A from a genotype 1b Con1 strain (JFH1/5ACon1). We introduced A92K or P32del solely or in combination with Q24K, L28M, R30Q or L31F into the NS5A of JFH1/5ACon1. Viruses harboring R30Q/A92K showed high extracellular core antigens and infectivity titers, whereas the other viruses with RASs showed low replication levels and infectivity titers. All the viruses with A92K or P32del were markedly resistant to ledipasvir, velpatasvir and elbasvir. Interestingly, viruses with R30Q/A92K were more susceptible to grazoprevir than viruses without RAS. All the viruses had a similar susceptibility to ribavirin and sofosbuvir. In conclusion, combination RASs R30Q/A92K enhanced virus production whereas other RASs impaired virus replication. Both A92K and P32del conferred severe resistance even to second generation NS5A inhibitors. However, these viruses were susceptible to grazoprevir, ribavirin and sofosbuvir. Thus, combination regimens with these reagents may eradicate viruses harboring A92K or P32del." @default.
• W2931964518 created "2019-04-11" @default.
• W2931964518 creator A5004001589 @default.
• W2931964518 creator A5006887009 @default.
• W2931964518 creator A5011131626 @default.
• W2931964518 creator A5014107009 @default.
• W2931964518 creator A5020032798 @default.
• W2931964518 creator A5034660747 @default.
• W2931964518 creator A5034909949 @default.
• W2931964518 creator A5036529314 @default.
• W2931964518 creator A5038887844 @default.
• W2931964518 creator A5040891927 @default.
• W2931964518 creator A5045376146 @default.
• W2931964518 creator A5047368140 @default.
• W2931964518 creator A5063108279 @default.
• W2931964518 creator A5071655187 @default.
• W2931964518 creator A5083170735 @default.
• W2931964518 creator A5088118861 @default.
• W2931964518 creator A5088814392 @default.
• W2931964518 date "2019-04-05" @default.
• W2931964518 modified "2023-10-15" @default.
• W2931964518 title "Impact of novel NS5A resistance-associated substitutions of hepatitis C virus detected in treatment-experienced patients" @default.
• W2931964518 cites W1551301313 @default.
• W2931964518 cites W1807436464 @default.
• W2931964518 cites W1826210767 @default.
• W2931964518 cites W1975048863 @default.
• W2931964518 cites W1978562134 @default.
• W2931964518 cites W2010120205 @default.
• W2931964518 cites W2011175002 @default.
• W2931964518 cites W2042063943 @default.
• W2931964518 cites W2047829391 @default.
• W2931964518 cites W2047911275 @default.
• W2931964518 cites W2068253682 @default.
• W2931964518 cites W2112024536 @default.
• W2931964518 cites W2115466322 @default.
• W2931964518 cites W2118604821 @default.
• W2931964518 cites W2141200498 @default.
• W2931964518 cites W2148864053 @default.
• W2931964518 cites W2175038046 @default.
• W2931964518 cites W2185218296 @default.
• W2931964518 cites W2277092291 @default.
• W2931964518 cites W2277765825 @default.
• W2931964518 cites W2290971043 @default.
• W2931964518 cites W2318156787 @default.
• W2931964518 cites W2320330796 @default.
• W2931964518 cites W2394500959 @default.
• W2931964518 cites W2413213127 @default.
• W2931964518 cites W2417045008 @default.
• W2931964518 cites W2461004176 @default.
• W2931964518 cites W2533110376 @default.
• W2931964518 cites W2538194643 @default.
• W2931964518 cites W2546089585 @default.
• W2931964518 cites W2560223644 @default.
• W2931964518 cites W2575880746 @default.
• W2931964518 cites W2588942442 @default.
• W2931964518 cites W2600733381 @default.
• W2931964518 cites W2749229801 @default.
• W2931964518 cites W2766054212 @default.
• W2931964518 cites W2768486652 @default.
• W2931964518 cites W2769010101 @default.
• W2931964518 cites W2769758977 @default.
• W2931964518 cites W2769985632 @default.
• W2931964518 cites W2774567315 @default.
• W2931964518 cites W2776863497 @default.
• W2931964518 cites W2790565500 @default.
• W2931964518 cites W2803594053 @default.
• W2931964518 cites W2890778396 @default.
• W2931964518 doi "https://doi.org/10.1038/s41598-019-42114-z" @default.
• W2931964518 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6450881" @default.
• W2931964518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30952914" @default.
• W2931964518 hasPublicationYear "2019" @default.
• W2931964518 type Work @default.
• W2931964518 sameAs 2931964518 @default.
• W2931964518 citedByCount "10" @default.
• W2931964518 countsByYear W29319645182019 @default.
• W2931964518 countsByYear W29319645182020 @default.
• W2931964518 countsByYear W29319645182021 @default.
• W2931964518 countsByYear W29319645182022 @default.
• W2931964518 crossrefType "journal-article" @default.
• W2931964518 hasAuthorship W2931964518A5004001589 @default.
• W2931964518 hasAuthorship W2931964518A5006887009 @default.
• W2931964518 hasAuthorship W2931964518A5011131626 @default.
• W2931964518 hasAuthorship W2931964518A5014107009 @default.
• W2931964518 hasAuthorship W2931964518A5020032798 @default.
• W2931964518 hasAuthorship W2931964518A5034660747 @default.
• W2931964518 hasAuthorship W2931964518A5034909949 @default.
• W2931964518 hasAuthorship W2931964518A5036529314 @default.
• W2931964518 hasAuthorship W2931964518A5038887844 @default.
• W2931964518 hasAuthorship W2931964518A5040891927 @default.
• W2931964518 hasAuthorship W2931964518A5045376146 @default.
• W2931964518 hasAuthorship W2931964518A5047368140 @default.
• W2931964518 hasAuthorship W2931964518A5063108279 @default.
• W2931964518 hasAuthorship W2931964518A5071655187 @default.
• W2931964518 hasAuthorship W2931964518A5083170735 @default.
• W2931964518 hasAuthorship W2931964518A5088118861 @default.
• W2931964518 hasAuthorship W2931964518A5088814392 @default.
• W2931964518 hasBestOaLocation W29319645181 @default.
• W2931964518 hasConcept C106358424 @default.
• W2931964518 hasConcept C159047783 @default.
• W2931964518 hasConcept C2522874641 @default.

• next