Matches in SemOpenAlex for { <https://semopenalex.org/work/W2932040131> ?p ?o ?g. }
- W2932040131 endingPage "600" @default.
- W2932040131 startingPage "591" @default.
- W2932040131 abstract "Introduction: Preclinical Alzheimer’s disease (AD) is characterized by amyloid-related cognitive decline. Reduction in this decline is used to determine the efficacy of drug therapies designed to forestall the disease in preclinical AD clinical trials, measured by a Preclinical Alzheimer’s Cognitive Composite (PACC). Most studies estimate rates of cognitive change by comparing cognitively normal (CN) older adults with abnormally high beta-amyloid (Aβ+) to those with low levels (Aβ–). However, participants of preclinical AD clinical trials must be Aβ+ for entry. Therefore, we estimated the effect of very high amyloid (Aβ++) and Aβ+ on cognitive change over three years measured by different versions of the PACC in individuals with preclinical AD.Method: CN older adults underwent Aβ neuroimaging and neuropsychological assessments over three years as part of the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Three cognitive composite scores were computed: the Alzheimer’s Disease Cooperative Study (ADCS)–PACC, the ADCS–PACC with no Mini-Mental State Examination (MMSE), and the z-scores of Attention, Verbal Fluency and Episodic Memory for Nondemented Older Adults (ZAVEN) composite.Results: Compared to the Aβ++ group, the Aβ+ group showed a slower rate of cognitive decline with the largest magnitude of difference reflected by the ADCS–PACC (d = 0.85). The ADCS–PACC excluding the MMSE and the ZAVEN also reflected a moderate to large magnitude of difference between groups (d = 0.62, d = 0.72, respectively).Conclusions: When all individuals have abnormal Aβ, the level of Aβ at baseline is associated with the rate of subsequent decline. The ADCS–PACC was the most sensitive composite score in showing that lower Aβ is associated with a slower rate of cognitive decline; however, there are limitations to the use of the MMSE. These results provide a benchmark of comparison for preclinical AD clinical trials aiming to slow cognitive deterioration." @default.
- W2932040131 created "2019-04-11" @default.
- W2932040131 creator A5011664920 @default.
- W2932040131 creator A5025220020 @default.
- W2932040131 creator A5031167354 @default.
- W2932040131 creator A5038030458 @default.
- W2932040131 creator A5047385288 @default.
- W2932040131 creator A5058052951 @default.
- W2932040131 creator A5060440287 @default.
- W2932040131 creator A5063088763 @default.
- W2932040131 creator A5064879007 @default.
- W2932040131 creator A5087120889 @default.
- W2932040131 creator A5089807849 @default.
- W2932040131 date "2019-03-29" @default.
- W2932040131 modified "2023-10-08" @default.
- W2932040131 title "Sensitivity of a Preclinical Alzheimer’s Cognitive Composite (PACC) to amyloid β load in preclinical Alzheimer’s disease" @default.
- W2932040131 cites W1964464904 @default.
- W2932040131 cites W2003569140 @default.
- W2932040131 cites W2011195206 @default.
- W2932040131 cites W2019103388 @default.
- W2932040131 cites W2029957233 @default.
- W2932040131 cites W2031696070 @default.
- W2932040131 cites W2058690573 @default.
- W2932040131 cites W2075348467 @default.
- W2932040131 cites W2087011519 @default.
- W2932040131 cites W2093445152 @default.
- W2932040131 cites W2094565995 @default.
- W2932040131 cites W2105071925 @default.
- W2932040131 cites W2110811354 @default.
- W2932040131 cites W2112519660 @default.
- W2932040131 cites W2112579276 @default.
- W2932040131 cites W2115799070 @default.
- W2932040131 cites W2129497119 @default.
- W2932040131 cites W2134711807 @default.
- W2932040131 cites W2135771073 @default.
- W2932040131 cites W2166281097 @default.
- W2932040131 cites W2213220213 @default.
- W2932040131 cites W2415123897 @default.
- W2932040131 cites W2767453481 @default.
- W2932040131 cites W2798054687 @default.
- W2932040131 cites W2802659348 @default.
- W2932040131 cites W380069984 @default.
- W2932040131 doi "https://doi.org/10.1080/13803395.2019.1593949" @default.
- W2932040131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30924399" @default.
- W2932040131 hasPublicationYear "2019" @default.
- W2932040131 type Work @default.
- W2932040131 sameAs 2932040131 @default.
- W2932040131 citedByCount "15" @default.
- W2932040131 countsByYear W29320401312020 @default.
- W2932040131 countsByYear W29320401312021 @default.
- W2932040131 countsByYear W29320401312022 @default.
- W2932040131 countsByYear W29320401312023 @default.
- W2932040131 crossrefType "journal-article" @default.
- W2932040131 hasAuthorship W2932040131A5011664920 @default.
- W2932040131 hasAuthorship W2932040131A5025220020 @default.
- W2932040131 hasAuthorship W2932040131A5031167354 @default.
- W2932040131 hasAuthorship W2932040131A5038030458 @default.
- W2932040131 hasAuthorship W2932040131A5047385288 @default.
- W2932040131 hasAuthorship W2932040131A5058052951 @default.
- W2932040131 hasAuthorship W2932040131A5060440287 @default.
- W2932040131 hasAuthorship W2932040131A5063088763 @default.
- W2932040131 hasAuthorship W2932040131A5064879007 @default.
- W2932040131 hasAuthorship W2932040131A5087120889 @default.
- W2932040131 hasAuthorship W2932040131A5089807849 @default.
- W2932040131 hasConcept C118552586 @default.
- W2932040131 hasConcept C126322002 @default.
- W2932040131 hasConcept C14216870 @default.
- W2932040131 hasConcept C143998085 @default.
- W2932040131 hasConcept C15744967 @default.
- W2932040131 hasConcept C169900460 @default.
- W2932040131 hasConcept C185711340 @default.
- W2932040131 hasConcept C2778373026 @default.
- W2932040131 hasConcept C2779134260 @default.
- W2932040131 hasConcept C2779483572 @default.
- W2932040131 hasConcept C2781073650 @default.
- W2932040131 hasConcept C2984863031 @default.
- W2932040131 hasConcept C502032728 @default.
- W2932040131 hasConcept C535046627 @default.
- W2932040131 hasConcept C58693492 @default.
- W2932040131 hasConcept C71924100 @default.
- W2932040131 hasConcept C88576662 @default.
- W2932040131 hasConcept C97530452 @default.
- W2932040131 hasConceptScore W2932040131C118552586 @default.
- W2932040131 hasConceptScore W2932040131C126322002 @default.
- W2932040131 hasConceptScore W2932040131C14216870 @default.
- W2932040131 hasConceptScore W2932040131C143998085 @default.
- W2932040131 hasConceptScore W2932040131C15744967 @default.
- W2932040131 hasConceptScore W2932040131C169900460 @default.
- W2932040131 hasConceptScore W2932040131C185711340 @default.
- W2932040131 hasConceptScore W2932040131C2778373026 @default.
- W2932040131 hasConceptScore W2932040131C2779134260 @default.
- W2932040131 hasConceptScore W2932040131C2779483572 @default.
- W2932040131 hasConceptScore W2932040131C2781073650 @default.
- W2932040131 hasConceptScore W2932040131C2984863031 @default.
- W2932040131 hasConceptScore W2932040131C502032728 @default.
- W2932040131 hasConceptScore W2932040131C535046627 @default.
- W2932040131 hasConceptScore W2932040131C58693492 @default.
- W2932040131 hasConceptScore W2932040131C71924100 @default.