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• W2932076020 abstract "Abstract Hepatitis B virus (HBV)-induced hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths in Asia and Africa. Developing effective and non-invasive biomarkers of HCC for individual patients remains an urgent task for early diagnosis and convenient monitoring. Analyzing the transcriptomic profiles of peripheral blood mononuclear cells from both healthy donors and patients with chronic HBV infection in different states (i.e. HBV carrier, chronic hepatitis B, cirrhosis, and HCC), we identified a set of 19 candidate genes according to our algorithm of dynamic network biomarkers. These genes can both characterize different stages during HCC progression and identify cirrhosis as the critical transition stage before carcinogenesis. The interaction effects (i.e. co-expressions) of candidate genes were used to build an accurate prediction model: the so-called edge-based biomarker. Considering the convenience and robustness of biomarkers in clinical applications, we performed functional analysis, validated candidate genes in other independent samples of our collected cohort, and finally selected COL5A1, HLA-DQB1, MMP2, and CDK4 to build edge panel as prediction models. We demonstrated that the edge panel had great performance in both diagnosis and prognosis in terms of precision and specificity for HCC, especially for patients with alpha-fetoprotein-negative HCC. Our study not only provides a novel edge-based biomarker for non-invasive and effective diagnosis of HBV-associated HCC to each individual patient but also introduces a new way to integrate the interaction terms of individual molecules for clinical diagnosis and prognosis from the network and dynamics perspectives." @default.
• W2932076020 created "2019-04-11" @default.
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• W2932076020 date "2019-04-08" @default.
• W2932076020 modified "2023-10-16" @default.
• W2932076020 title "Dynamic edge-based biomarker non-invasively predicts hepatocellular carcinoma with hepatitis B virus infection for individual patients based on blood testing" @default.
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• W2932076020 cites W1563116290 @default.
• W2932076020 cites W1769407698 @default.
• W2932076020 cites W1822560101 @default.
• W2932076020 cites W1957852926 @default.
• W2932076020 cites W1964220623 @default.
• W2932076020 cites W1975003292 @default.
• W2932076020 cites W1984106888 @default.
• W2932076020 cites W1991713904 @default.
• W2932076020 cites W199647299 @default.
• W2932076020 cites W2003866854 @default.
• W2932076020 cites W2008602660 @default.
• W2932076020 cites W2008632796 @default.
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• W2932076020 cites W2093506975 @default.
• W2932076020 cites W2100238813 @default.
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• W2932076020 cites W2125272092 @default.
• W2932076020 cites W2137794530 @default.
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• W2932076020 cites W2143604872 @default.
• W2932076020 cites W2151782484 @default.
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• W2932076020 cites W2407778923 @default.
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• W2932076020 cites W2411378979 @default.
• W2932076020 cites W2468118389 @default.
• W2932076020 cites W2494078024 @default.
• W2932076020 cites W2508622936 @default.
• W2932076020 cites W2546679226 @default.
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• W2932076020 doi "https://doi.org/10.1093/jmcb/mjz025" @default.
• W2932076020 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6788726" @default.
• W2932076020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30925583" @default.
• W2932076020 hasPublicationYear "2019" @default.
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