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- W293207910 abstract "To investigate the effect of cell adhesion molecule P-selectin monoclonal antibody (Mab) on metastasis and immune function of mice orthototopically implanted with human gastric cancer tissue.SCID mice were implanted orthotopically with SGC-7901 human gastric carcinoma tissue. Starting from day 3 after operation, animals were given intravenously PBS or P-selectin Mab (100 microg/injection) (for both normal mice and tumor-implanted mice with tumors), twice weekly for 3 weeks. Two animals in each group were sacrificed randomly at the 1st, 2nd, 4th week and 6th week. While T cell and B cell transformation indices were determined with the (3)H TdR infiltration method, the NK cell activity was detected by the LDH release method.The metastatic rate in the P-selectin Mab treated group was lower than that in the PBS treated group (with tumors). The NK activity of normal mice increased over time. The immune functions (T, B cell function, NK activity) of the tumor group in the 6th week were significantly lower than those in the 4th week, but the change was attenuated by P-selectin Mab.P-selectin Mab could suppress the metastasis of gastric cancer with no adverse effect on host immune function." @default.
- W293207910 created "2016-06-24" @default.
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- W293207910 date "2003-01-01" @default.
- W293207910 modified "2023-09-26" @default.
- W293207910 title "Effect of P-selectin monoclonal antibody on metastasis of gastric cancer and immune function" @default.
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- W293207910 doi "https://doi.org/10.3748/wjg.v9.i7.1607" @default.
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