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• W2932108898 abstract "Abstract Mutations in the PARK2 gene are associated with early onset Parkinsonism. The Park2 −/− mouse, however, does not exhibit neurodegeneration or other Parkinson’s disease (PD) phenotypes. Previously, we discovered that translation of Mcl-1, a pro-survival factor, is upregulated in the Park2 −/− mouse, suggesting a compensatory mechanism during development. Here we generated the Park2 −/− Mcl-1 +/− mouse and show that by reducing Mcl-1 gene dosage by 50%, the Park2 −/− genotype is sensitized, conferring both dopaminergic neuron loss and motor impairments. We propose that this murine model could be a useful tool for dissecting PD etiology and developing treatment strategies against this neurodegenerative disease." @default.
• W2932108898 created "2019-04-11" @default.
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• W2932108898 date "2019-04-04" @default.
• W2932108898 modified "2023-10-14" @default.
• W2932108898 title "Reducing Mcl-1 gene dosage induces dopaminergic neuronal loss and motor impairments in Park2 knockout mice" @default.
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• W2932108898 doi "https://doi.org/10.1038/s42003-019-0366-x" @default.
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