FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2932239904> ?p ?o ?g. }

• W2932239904 abstract "Gene-targeted mice with deficient AMPA receptor GluA1 subunits (Gria1-/- mice) show robust hyperlocomotion in a novel environment, suggesting them to constitute a model for hyperactivity disorders such as mania, schizophrenia and attention deficit hyperactivity disorder. This behavioral alteration has been associated with increased neuronal activation in the hippocampus, and it can be attenuated by chronic treatment with antimanic drugs, such as lithium, valproic acid and lamotrigine. Now we found that systemic cannabidiol strongly blunted the hyperactivity and the hippocampal c-Fos expression of the Gria1-/- mice, while not affecting the wildtype littermate controls. Acute bilateral intra-dorsal hippocampal infusion of cannabidiol partially blocked the hyperactivity of the Gria1-/- mice, but had no effect on wildtypes. The activation of the inhibitory DREADD receptor hM4Gi in the dorsal hippocampus by clozapine-N-oxide robustly inhibited the hyperactivity of the Gria1-/- mice, but had no effect on the locomotion of wildtype mice. Our results show that enhanced neuronal excitability in the hippocampus is associated with pronounced novelty-induced hyperactivity of GluA1 subunit-deficient mice. When this enhanced response of hippocampal neurons to novel stimuli is specifically reduced in the hippocampus by pharmacological treatment or by chemogenetic inhibition, Gria1-/- mice recover from behavioral hyperactivity, suggesting a hippocampal dysfunction in hyperactive behaviors that can be treated with cannabidiol." @default.
• W2932239904 created "2019-04-11" @default.
• W2932239904 creator A5009783365 @default.
• W2932239904 creator A5014779572 @default.
• W2932239904 creator A5016040751 @default.
• W2932239904 creator A5022791897 @default.
• W2932239904 creator A5066158586 @default.
• W2932239904 date "2019-03-29" @default.
• W2932239904 modified "2023-09-26" @default.
• W2932239904 title "Attenuation of Novelty-Induced Hyperactivity of Gria1-/- Mice by Cannabidiol and Hippocampal Inhibitory Chemogenetics" @default.
• W2932239904 cites W1166458116 @default.
• W2932239904 cites W1514328521 @default.
• W2932239904 cites W1593785499 @default.
• W2932239904 cites W1884361550 @default.
• W2932239904 cites W1966403223 @default.
• W2932239904 cites W1970852406 @default.
• W2932239904 cites W1981789373 @default.
• W2932239904 cites W1984754469 @default.
• W2932239904 cites W1985431195 @default.
• W2932239904 cites W1987998857 @default.
• W2932239904 cites W1997396304 @default.
• W2932239904 cites W1998021006 @default.
• W2932239904 cites W1998189511 @default.
• W2932239904 cites W2010004476 @default.
• W2932239904 cites W2011259162 @default.
• W2932239904 cites W2015650006 @default.
• W2932239904 cites W2016575029 @default.
• W2932239904 cites W2016770429 @default.
• W2932239904 cites W2036494479 @default.
• W2932239904 cites W2036803444 @default.
• W2932239904 cites W2038207214 @default.
• W2932239904 cites W2040856930 @default.
• W2932239904 cites W2041273498 @default.
• W2932239904 cites W2052833744 @default.
• W2932239904 cites W2056468240 @default.
• W2932239904 cites W2057318097 @default.
• W2932239904 cites W2058112854 @default.
• W2932239904 cites W2058629787 @default.
• W2932239904 cites W2058996526 @default.
• W2932239904 cites W2062055735 @default.
• W2932239904 cites W2065831703 @default.
• W2932239904 cites W2066252334 @default.
• W2932239904 cites W2079010888 @default.
• W2932239904 cites W2079096922 @default.
• W2932239904 cites W2092270879 @default.
• W2932239904 cites W2093219983 @default.
• W2932239904 cites W2101233587 @default.
• W2932239904 cites W2101357408 @default.
• W2932239904 cites W2111954958 @default.
• W2932239904 cites W2115440397 @default.
• W2932239904 cites W2115807273 @default.
• W2932239904 cites W2125478459 @default.
• W2932239904 cites W2130784302 @default.
• W2932239904 cites W2140381473 @default.
• W2932239904 cites W2146773535 @default.
• W2932239904 cites W2149110258 @default.
• W2932239904 cites W2160854459 @default.
• W2932239904 cites W2166279367 @default.
• W2932239904 cites W2174548557 @default.
• W2932239904 cites W2275148408 @default.
• W2932239904 cites W2297423253 @default.
• W2932239904 cites W2462076112 @default.
• W2932239904 cites W2529445587 @default.
• W2932239904 cites W2530703593 @default.
• W2932239904 cites W2597459336 @default.
• W2932239904 cites W2733736690 @default.
• W2932239904 cites W2734580914 @default.
• W2932239904 cites W2739987531 @default.
• W2932239904 cites W2761862301 @default.
• W2932239904 cites W2766334411 @default.
• W2932239904 cites W2804376135 @default.
• W2932239904 cites W326814059 @default.
• W2932239904 doi "https://doi.org/10.3389/fphar.2019.00309" @default.
• W2932239904 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6449460" @default.
• W2932239904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30984001" @default.
• W2932239904 hasPublicationYear "2019" @default.
• W2932239904 type Work @default.
• W2932239904 sameAs 2932239904 @default.
• W2932239904 citedByCount "10" @default.
• W2932239904 countsByYear W29322399042020 @default.
• W2932239904 countsByYear W29322399042021 @default.
• W2932239904 countsByYear W29322399042022 @default.
• W2932239904 countsByYear W29322399042023 @default.
• W2932239904 crossrefType "journal-article" @default.
• W2932239904 hasAuthorship W2932239904A5009783365 @default.
• W2932239904 hasAuthorship W2932239904A5014779572 @default.
• W2932239904 hasAuthorship W2932239904A5016040751 @default.
• W2932239904 hasAuthorship W2932239904A5022791897 @default.
• W2932239904 hasAuthorship W2932239904A5066158586 @default.
• W2932239904 hasBestOaLocation W29322399041 @default.
• W2932239904 hasConcept C118552586 @default.
• W2932239904 hasConcept C126322002 @default.
• W2932239904 hasConcept C134018914 @default.
• W2932239904 hasConcept C148762608 @default.
• W2932239904 hasConcept C15744967 @default.
• W2932239904 hasConcept C169760540 @default.
• W2932239904 hasConcept C17077164 @default.
• W2932239904 hasConcept C185592680 @default.
• W2932239904 hasConcept C2776895053 @default.
• W2932239904 hasConcept C2777056318 @default.

• next