FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2932285812> ?p ?o ?g. }

• W2932285812 abstract "The circadian rhythm, which regulates various body functions, is transcriptionally controlled by a series of clock gene clusters. The clock genes are related to the pathology of various kinds of diseases, which in turn, is related to aging. Aging in humans is a worldwide problem; it induces sleep disorders and disruption of the circadian rhythm. It also decreases ocular vision and appetite and weakens the synchronization of clock genes by light and food. Therefore, a simple method for the synchronization of clock genes in the body is required. In this study, the influence of microcurrent stimulation (MCS) on the circadian machinery in wild-type (WT) and Clock mutant (Clk/Clk) mice was investigated. MCS induced Per1 mRNA expression in cultured mouse astrocytes; cAMP response element (CRE) in the Per1 mouse promoter was found to be important for the induction of Per1 mRNA. In addition, MCS increased the Per1 mRNA levels in mouse livers and caused the phase advance of the Per1 expression rhythm. The protein expression rhythm of phosphor-cAMP response element-binding protein (pCREB) was altered and the phase of expression of pCREB protein advanced. Finally, the influence of MCS on the locomotor activity rhythm in WT and Clk/Clk mice was investigated. MCS caused the phase advance of the locomotor activity rhythm in WT and Clk/Clk mice. The results of this study indicate that MCS activated the clock machinery in mice; MCS may thus improve the quality of new treatment modalities in the future." @default.
• W2932285812 created "2019-04-11" @default.
• W2932285812 creator A5010918379 @default.
• W2932285812 creator A5021044011 @default.
• W2932285812 creator A5030342247 @default.
• W2932285812 creator A5038270737 @default.
• W2932285812 creator A5040002011 @default.
• W2932285812 creator A5046939795 @default.
• W2932285812 creator A5063284996 @default.
• W2932285812 date "2019-05-01" @default.
• W2932285812 modified "2023-09-24" @default.
• W2932285812 title "Microcurrent stimulation activates the circadian machinery in mice" @default.
• W2932285812 cites W1970355769 @default.
• W2932285812 cites W1992494470 @default.
• W2932285812 cites W2006593535 @default.
• W2932285812 cites W2010104326 @default.
• W2932285812 cites W2011692694 @default.
• W2932285812 cites W2035809873 @default.
• W2932285812 cites W2035931981 @default.
• W2932285812 cites W2040196614 @default.
• W2932285812 cites W2054513544 @default.
• W2932285812 cites W2061764511 @default.
• W2932285812 cites W2066183013 @default.
• W2932285812 cites W2069293589 @default.
• W2932285812 cites W2073742199 @default.
• W2932285812 cites W2094589586 @default.
• W2932285812 cites W2105350887 @default.
• W2932285812 cites W2113297137 @default.
• W2932285812 cites W2137947730 @default.
• W2932285812 cites W2142478420 @default.
• W2932285812 cites W2144479739 @default.
• W2932285812 cites W2147077087 @default.
• W2932285812 cites W2152758470 @default.
• W2932285812 cites W2155318763 @default.
• W2932285812 cites W2162288394 @default.
• W2932285812 cites W2164166968 @default.
• W2932285812 cites W2165543096 @default.
• W2932285812 cites W2396518873 @default.
• W2932285812 cites W2408708620 @default.
• W2932285812 cites W2479222723 @default.
• W2932285812 cites W2751470221 @default.
• W2932285812 cites W2777859002 @default.
• W2932285812 doi "https://doi.org/10.1016/j.bbrc.2019.02.022" @default.
• W2932285812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30944082" @default.
• W2932285812 hasPublicationYear "2019" @default.
• W2932285812 type Work @default.
• W2932285812 sameAs 2932285812 @default.
• W2932285812 citedByCount "1" @default.
• W2932285812 countsByYear W29322858122020 @default.
• W2932285812 crossrefType "journal-article" @default.
• W2932285812 hasAuthorship W2932285812A5010918379 @default.
• W2932285812 hasAuthorship W2932285812A5021044011 @default.
• W2932285812 hasAuthorship W2932285812A5030342247 @default.
• W2932285812 hasAuthorship W2932285812A5038270737 @default.
• W2932285812 hasAuthorship W2932285812A5040002011 @default.
• W2932285812 hasAuthorship W2932285812A5046939795 @default.
• W2932285812 hasAuthorship W2932285812A5063284996 @default.
• W2932285812 hasConcept C121446783 @default.
• W2932285812 hasConcept C126322002 @default.
• W2932285812 hasConcept C134018914 @default.
• W2932285812 hasConcept C184738001 @default.
• W2932285812 hasConcept C2780360009 @default.
• W2932285812 hasConcept C38606739 @default.
• W2932285812 hasConcept C71924100 @default.
• W2932285812 hasConcept C86803240 @default.
• W2932285812 hasConcept C95444343 @default.
• W2932285812 hasConceptScore W2932285812C121446783 @default.
• W2932285812 hasConceptScore W2932285812C126322002 @default.
• W2932285812 hasConceptScore W2932285812C134018914 @default.
• W2932285812 hasConceptScore W2932285812C184738001 @default.
• W2932285812 hasConceptScore W2932285812C2780360009 @default.
• W2932285812 hasConceptScore W2932285812C38606739 @default.
• W2932285812 hasConceptScore W2932285812C71924100 @default.
• W2932285812 hasConceptScore W2932285812C86803240 @default.
• W2932285812 hasConceptScore W2932285812C95444343 @default.
• W2932285812 hasFunder F4320311405 @default.
• W2932285812 hasLocation W29322858121 @default.
• W2932285812 hasLocation W29322858122 @default.
• W2932285812 hasOpenAccess W2932285812 @default.
• W2932285812 hasPrimaryLocation W29322858121 @default.
• W2932285812 hasRelatedWork W1973760267 @default.
• W2932285812 hasRelatedWork W1980685856 @default.
• W2932285812 hasRelatedWork W2004306339 @default.
• W2932285812 hasRelatedWork W2009571829 @default.
• W2932285812 hasRelatedWork W2073931907 @default.
• W2932285812 hasRelatedWork W2113511986 @default.
• W2932285812 hasRelatedWork W2154015628 @default.
• W2932285812 hasRelatedWork W2271811454 @default.
• W2932285812 hasRelatedWork W2970947312 @default.
• W2932285812 hasRelatedWork W399055038 @default.
• W2932285812 isParatext "false" @default.
• W2932285812 isRetracted "false" @default.
• W2932285812 magId "2932285812" @default.
• W2932285812 workType "article" @default.