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• W2932955749 abstract "Abstract Stearoyl-CoA desaturases (SCD) are endoplasmic reticulum (ER) associated enzymes that catalyze the synthesis of the monounsaturated fatty acids (MUFAs). As such, SCD play important roles in maintaining the intracellular balance between saturated fatty acid (SFAs) and MUFAs. The roles of SCD in CD4 + T helper cell responses are currently unexplored. Here, we have found that murine and human follicular helper T (T FH ) cells express higher levels of SCD1 compared to non-T FH cells. Further, the expression of SCD1 in T FH cells is dependent on the T FH lineage-specification transcription factor BCL6. We found that the inhibition of SCD1 impaired T FH cell maintenance and shifted the balance between T FH and follicular regulatory T (T FR ) cells in the spleen. Consequently, SCD1 inhibition dampened germinal center B cell responses following influenza immunization. Mechanistically, we found that SCD inhibition led to increased ER stress and enhanced T FH cell apoptosis in vitro and in vivo . These results reveal a possible link between fatty acid metabolism and cellular and humoral responses induced by immunization or potentially, autoimmunity." @default.
• W2932955749 created "2019-04-11" @default.
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• W2932955749 date "2019-04-07" @default.
• W2932955749 modified "2023-10-18" @default.
• W2932955749 title "Inhibition of Stearoyl-CoA desaturase suppresses follicular help T and germinal center B cell responses" @default.
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• W2932955749 doi "https://doi.org/10.1101/601021" @default.
• W2932955749 hasPublicationYear "2019" @default.
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