FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2932958950> ?p ?o ?g. }

• W2932958950 abstract "Neuronal calcium sensor-1 (NCS-1) knockout (KO) in mice (NCS-1-/- mice) evokes behavioral phenotypes ranging from learning deficits to avolition and depressive-like behaviors. Here, we showed that with the onset of adulthood NCS-1-/- mice gain considerable weight. Adult NCS-1-/- mice are obese, especially when fed a high-fat diet (HFD), are hyperglycemic and hyperinsulinemic and thus develop a diabetes type 2 phenotype. In comparison to wild type (WT) NCS-1-/- mice display a significant increase in adipose tissue mass. NCS-1-/- adipocytes produce insufficient serum concentrations of resistin and adiponectin. In contrast to WT littermates, adipocytes of NCS-1-/- mice are incapable of up-regulating insulin receptor (IR) concentration in response to HFD. Thus, HFD-fed NCS-1-/- mice exhibit in comparison to WT littermates a significantly reduced IR expression, which may explain the pronounced insulin resistance observed especially with HFD-fed NCS-1-/- mice. We observed a direct correlation between NCS-1 and IR concentrations in the adipocyte membrane and that NCS-1 can be co-immunoprecipitated with IR indicating a direct interplay between NCS-1 and IR. We propose that NCS-1 plays an important role in adipocyte function and that NCS-1 deficiency gives rise to obesity and diabetes type 2 in adult mice. Given the association of altered NCS-1 expression with behaviorial abnormalities, NCS-1-/- mice may offer an interesting perspective for studying in a mouse model a potential genetic link between some psychiatric disorders and the risk of being obese." @default.
• W2932958950 created "2019-04-11" @default.
• W2932958950 creator A5025630114 @default.
• W2932958950 creator A5046516877 @default.
• W2932958950 creator A5052139061 @default.
• W2932958950 creator A5071615457 @default.
• W2932958950 date "2019-04-03" @default.
• W2932958950 modified "2023-10-18" @default.
• W2932958950 title "NCS-1 Deficiency Is Associated With Obesity and Diabetes Type 2 in Mice" @default.
• W2932958950 cites W1524321743 @default.
• W2932958950 cites W1631449371 @default.
• W2932958950 cites W1675830194 @default.
• W2932958950 cites W1831040894 @default.
• W2932958950 cites W1968963646 @default.
• W2932958950 cites W1969589380 @default.
• W2932958950 cites W1975898092 @default.
• W2932958950 cites W1977601765 @default.
• W2932958950 cites W1978590803 @default.
• W2932958950 cites W1984928606 @default.
• W2932958950 cites W1986557295 @default.
• W2932958950 cites W1988800094 @default.
• W2932958950 cites W1997607386 @default.
• W2932958950 cites W2009006606 @default.
• W2932958950 cites W2009172922 @default.
• W2932958950 cites W2023415096 @default.
• W2932958950 cites W2031781678 @default.
• W2932958950 cites W2035168927 @default.
• W2932958950 cites W2036976244 @default.
• W2932958950 cites W2040106495 @default.
• W2932958950 cites W2048596524 @default.
• W2932958950 cites W2048793124 @default.
• W2932958950 cites W2051746145 @default.
• W2932958950 cites W2051820078 @default.
• W2932958950 cites W2063234089 @default.
• W2932958950 cites W2063418259 @default.
• W2932958950 cites W2067684598 @default.
• W2932958950 cites W2070624893 @default.
• W2932958950 cites W2074076323 @default.
• W2932958950 cites W2076801049 @default.
• W2932958950 cites W2080910583 @default.
• W2932958950 cites W2085241231 @default.
• W2932958950 cites W2088940658 @default.
• W2932958950 cites W2094800813 @default.
• W2932958950 cites W2094970290 @default.
• W2932958950 cites W2107766012 @default.
• W2932958950 cites W2110137900 @default.
• W2932958950 cites W2127518311 @default.
• W2932958950 cites W2138625258 @default.
• W2932958950 cites W2141624015 @default.
• W2932958950 cites W2151303234 @default.
• W2932958950 cites W2151522859 @default.
• W2932958950 cites W2153710892 @default.
• W2932958950 cites W2163377635 @default.
• W2932958950 cites W2165877506 @default.
• W2932958950 cites W2209410074 @default.
• W2932958950 cites W2367846133 @default.
• W2932958950 cites W2419490500 @default.
• W2932958950 cites W2580499849 @default.
• W2932958950 cites W2582298896 @default.
• W2932958950 cites W2604786628 @default.
• W2932958950 cites W2777564170 @default.
• W2932958950 cites W2903711992 @default.
• W2932958950 cites W2905274784 @default.
• W2932958950 cites W4211007940 @default.
• W2932958950 doi "https://doi.org/10.3389/fnmol.2019.00078" @default.
• W2932958950 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6456702" @default.
• W2932958950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31001084" @default.
• W2932958950 hasPublicationYear "2019" @default.
• W2932958950 type Work @default.
• W2932958950 sameAs 2932958950 @default.
• W2932958950 citedByCount "7" @default.
• W2932958950 countsByYear W29329589502019 @default.
• W2932958950 countsByYear W29329589502020 @default.
• W2932958950 countsByYear W29329589502021 @default.
• W2932958950 countsByYear W29329589502023 @default.
• W2932958950 crossrefType "journal-article" @default.
• W2932958950 hasAuthorship W2932958950A5025630114 @default.
• W2932958950 hasAuthorship W2932958950A5046516877 @default.
• W2932958950 hasAuthorship W2932958950A5052139061 @default.
• W2932958950 hasAuthorship W2932958950A5071615457 @default.
• W2932958950 hasBestOaLocation W29329589501 @default.
• W2932958950 hasConcept C102230213 @default.
• W2932958950 hasConcept C104317684 @default.
• W2932958950 hasConcept C126322002 @default.
• W2932958950 hasConcept C127716648 @default.
• W2932958950 hasConcept C134018914 @default.
• W2932958950 hasConcept C141035611 @default.
• W2932958950 hasConcept C170493617 @default.
• W2932958950 hasConcept C171089720 @default.
• W2932958950 hasConcept C182704531 @default.
• W2932958950 hasConcept C185592680 @default.
• W2932958950 hasConcept C2776175234 @default.
• W2932958950 hasConcept C2776782570 @default.
• W2932958950 hasConcept C2777180221 @default.
• W2932958950 hasConcept C2777391703 @default.
• W2932958950 hasConcept C2779760629 @default.
• W2932958950 hasConcept C511355011 @default.
• W2932958950 hasConcept C55493867 @default.
• W2932958950 hasConcept C555293320 @default.
• W2932958950 hasConcept C71924100 @default.

• next