FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2933143332> ?p ?o ?g. }

• W2933143332 endingPage "4856" @default.
• W2933143332 startingPage "4848" @default.
• W2933143332 abstract "Abstract Context In end-stage renal disease (ESRD), serum high-density lipoprotein cholesterol (HDL-C) level is not an accurate predictor of mortality, partly because it does not necessarily correlate with indices of HDL function. Paraoxonase (PON) is a major enzyme constituent of HDL and a key component of HDL antioxidant activity. Apolipoprotein A-I (Apo A-1) is the core HDL structural protein that plays a major role in various aspects of HDL function. Objective We sought to examine PON activity and Apo A-I levels in patients with ESRD vs healthy controls. Design and Setting PON/arylesterase activity was measured in 499 patients with maintenance hemodialysis (MHD) and 24 healthy controls with similar distributions of age, sex, and race/ethnicity. Serum acrolein-modified Apo A-I was measured in 30 patients with MHD and 10 healthy controls. Main Outcome Measures Multilevel Cox models were used to assess associations among PON activity, Apo A-I, and HDL-C levels with 12-month all-cause mortality. Results PON activity was significantly lower in patients with MHD vs controls. Furthermore, acrolein-modified Apo A-I levels were higher in patients with MHD vs controls. In fully adjusted models, high PON activity was associated with lower 12-month mortality, whereas no difference of mortality risk was observed across HDL-C levels. The combination of high PON and low Apo A-I compared with low PON and low Apo A-I was associated with lower mortality risk. Conclusions In patients with MHD, PON activity had a stronger association with 12-month mortality than HDL-C. Future studies are needed to examine the role of these markers as potential diagnostic and therapeutic tools in ESRD." @default.
• W2933143332 created "2019-04-11" @default.
• W2933143332 creator A5011834257 @default.
• W2933143332 creator A5012481511 @default.
• W2933143332 creator A5018961761 @default.
• W2933143332 creator A5018989064 @default.
• W2933143332 creator A5023128609 @default.
• W2933143332 creator A5042511606 @default.
• W2933143332 creator A5044034699 @default.
• W2933143332 creator A5047313234 @default.
• W2933143332 creator A5056238061 @default.
• W2933143332 creator A5076871855 @default.
• W2933143332 creator A5084375517 @default.
• W2933143332 creator A5088002863 @default.
• W2933143332 creator A5090064043 @default.
• W2933143332 date "2019-03-28" @default.
• W2933143332 modified "2023-10-01" @default.
• W2933143332 title "Association of Serum Paraoxonase/Arylesterase Activity With All-Cause Mortality in Maintenance Hemodialysis Patients" @default.
• W2933143332 cites W1545920186 @default.
• W2933143332 cites W1552709412 @default.
• W2933143332 cites W1967891035 @default.
• W2933143332 cites W1977756812 @default.
• W2933143332 cites W1993510264 @default.
• W2933143332 cites W2000811971 @default.
• W2933143332 cites W2020888421 @default.
• W2933143332 cites W2040038248 @default.
• W2933143332 cites W2051962851 @default.
• W2933143332 cites W2053826548 @default.
• W2933143332 cites W2057572769 @default.
• W2933143332 cites W2065175310 @default.
• W2933143332 cites W2072157574 @default.
• W2933143332 cites W2073571905 @default.
• W2933143332 cites W2075453596 @default.
• W2933143332 cites W2084075677 @default.
• W2933143332 cites W2092389007 @default.
• W2933143332 cites W2096220628 @default.
• W2933143332 cites W2102399845 @default.
• W2933143332 cites W2110318177 @default.
• W2933143332 cites W2113956623 @default.
• W2933143332 cites W2127427274 @default.
• W2933143332 cites W2133990668 @default.
• W2933143332 cites W2139976637 @default.
• W2933143332 cites W2140455131 @default.
• W2933143332 cites W2148923792 @default.
• W2933143332 cites W2158057499 @default.
• W2933143332 cites W2167656536 @default.
• W2933143332 cites W2169664803 @default.
• W2933143332 cites W2280498603 @default.
• W2933143332 cites W2339616051 @default.
• W2933143332 cites W2512996508 @default.
• W2933143332 cites W2518450497 @default.
• W2933143332 cites W2576750626 @default.
• W2933143332 cites W2606324234 @default.
• W2933143332 cites W2736460452 @default.
• W2933143332 cites W2769328074 @default.
• W2933143332 cites W2788810039 @default.
• W2933143332 cites W2804198857 @default.
• W2933143332 cites W4243601884 @default.
• W2933143332 doi "https://doi.org/10.1210/jc.2019-00334" @default.
• W2933143332 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6733492" @default.
• W2933143332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30920627" @default.
• W2933143332 hasPublicationYear "2019" @default.
• W2933143332 type Work @default.
• W2933143332 sameAs 2933143332 @default.
• W2933143332 citedByCount "13" @default.
• W2933143332 countsByYear W29331433322020 @default.
• W2933143332 countsByYear W29331433322021 @default.
• W2933143332 countsByYear W29331433322022 @default.
• W2933143332 countsByYear W29331433322023 @default.
• W2933143332 crossrefType "journal-article" @default.
• W2933143332 hasAuthorship W2933143332A5011834257 @default.
• W2933143332 hasAuthorship W2933143332A5012481511 @default.
• W2933143332 hasAuthorship W2933143332A5018961761 @default.
• W2933143332 hasAuthorship W2933143332A5018989064 @default.
• W2933143332 hasAuthorship W2933143332A5023128609 @default.
• W2933143332 hasAuthorship W2933143332A5042511606 @default.
• W2933143332 hasAuthorship W2933143332A5044034699 @default.
• W2933143332 hasAuthorship W2933143332A5047313234 @default.
• W2933143332 hasAuthorship W2933143332A5056238061 @default.
• W2933143332 hasAuthorship W2933143332A5076871855 @default.
• W2933143332 hasAuthorship W2933143332A5084375517 @default.
• W2933143332 hasAuthorship W2933143332A5088002863 @default.
• W2933143332 hasAuthorship W2933143332A5090064043 @default.
• W2933143332 hasBestOaLocation W29331433321 @default.
• W2933143332 hasConcept C104317684 @default.
• W2933143332 hasConcept C126322002 @default.
• W2933143332 hasConcept C134018914 @default.
• W2933143332 hasConcept C135763542 @default.
• W2933143332 hasConcept C151730666 @default.
• W2933143332 hasConcept C2776151105 @default.
• W2933143332 hasConcept C2776509667 @default.
• W2933143332 hasConcept C2778063415 @default.
• W2933143332 hasConcept C2778163477 @default.
• W2933143332 hasConcept C2779343474 @default.
• W2933143332 hasConcept C2781389560 @default.
• W2933143332 hasConcept C37501387 @default.
• W2933143332 hasConcept C55493867 @default.
• W2933143332 hasConcept C62746215 @default.

• next