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• W2933144130 abstract "Abstract Background Patients with diabetes mellitus are at high risk for onychomycosis, which is related to the development of foot ulcers. Objective The aim of this study was to evaluate the safety and efficacy of the treatment of onychomycosis with local laser therapy. Methods In a single‐centre, randomized (1:1), quadruple‐blind, sham‐controlled trial, patients and microbiological confirmation with diabetes mellitus, at risk for developing diabetic foot ulcers (Sims classification score 1, 2) and a clinical suspicion on onychomycosis, were randomized to either four sessions neodymium‐doped yttrium aluminium garnet (Nd‐ YAG ) 1064 nm laser or sham treatment. The primary outcome was clinical and microbiological cure of onychomycosis after 1‐year follow‐up. Results From March 2015 to July 2016, 64 patients were randomized; 63 could be analysed. Trichophyton rubrum was the most detected pathogen. There was no difference in the primary outcome between laser and sham treatment. With the exception of a subungual haematoma in the fifth toenail occurring 2 weeks after laser treatment, the results suggested that treatment with Nd‐ YAG 1064 nm laser is safe. Conclusion At this moment, there is no evidence of any effect of laser treatment for onychomycosis in patients with diabetes at increased risk for foot ulcers, at least not within 1 year after treatment." @default.
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• W2933144130 date "2019-07-09" @default.
• W2933144130 modified "2023-09-30" @default.
• W2933144130 title "Laser therapy for onychomycosis in patients with diabetes at risk for foot ulcers: a randomized, quadruple‐blind, sham‐controlled trial ( <scp>LASER</scp> ‐1)" @default.
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• W2933144130 doi "https://doi.org/10.1111/jdv.15601" @default.
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