Matches in SemOpenAlex for { <https://semopenalex.org/work/W2933152452> ?p ?o ?g. }
- W2933152452 abstract "SUMMARY In most vertebrates, the upper digestive tract is composed of muscularised jaws linked to the esophagus that permit food uptake and swallowing. Masticatory and esophagus striated muscles (ESM) share a common cardiopharyngeal mesoderm (CPM) origin, however ESM are unusual among striated muscles as they are established in the absence of a primary skeletal muscle scaffold. Using mouse chimeras, we show that the transcription factors Tbx1 and Isl1 are required cell-autonomously for myogenic specification of ESM progenitors. Further, genetic loss-of-function and pharmacological studies point to Met/HGF signalling for antero-posterior migration of esophagus muscle progenitors, where HGF ligand is expressed in adjacent smooth muscle cells. These observations highlight the functional relevance of a smooth and striated muscle progenitor dialogue for ESM patterning. Our findings establish a Tbx1-Isl1-Met genetic hierarchy that uniquely regulate esophagus myogenesis and identify distinct genetic signatures that can be used as a framework to interpret pathologies arising within CPM derivatives." @default.
- W2933152452 created "2019-04-11" @default.
- W2933152452 creator A5003450706 @default.
- W2933152452 creator A5011256781 @default.
- W2933152452 creator A5019068409 @default.
- W2933152452 creator A5024146511 @default.
- W2933152452 creator A5030444472 @default.
- W2933152452 creator A5070407254 @default.
- W2933152452 creator A5070408333 @default.
- W2933152452 creator A5079202548 @default.
- W2933152452 creator A5086054108 @default.
- W2933152452 date "2019-04-05" @default.
- W2933152452 modified "2023-09-25" @default.
- W2933152452 title "A distinct cardiopharyngeal mesoderm genetic hierarchy establishes antero-posterior patterning of esophagus striated muscle" @default.
- W2933152452 cites W1501608538 @default.
- W2933152452 cites W1860843617 @default.
- W2933152452 cites W1920673272 @default.
- W2933152452 cites W1960895270 @default.
- W2933152452 cites W1966563415 @default.
- W2933152452 cites W1966789201 @default.
- W2933152452 cites W1966955508 @default.
- W2933152452 cites W1967533362 @default.
- W2933152452 cites W1972225708 @default.
- W2933152452 cites W1972607682 @default.
- W2933152452 cites W1990244564 @default.
- W2933152452 cites W1993130090 @default.
- W2933152452 cites W1998066648 @default.
- W2933152452 cites W1998732473 @default.
- W2933152452 cites W2003334013 @default.
- W2933152452 cites W2004266019 @default.
- W2933152452 cites W2004543760 @default.
- W2933152452 cites W2004602258 @default.
- W2933152452 cites W2005471991 @default.
- W2933152452 cites W2008726032 @default.
- W2933152452 cites W2022527563 @default.
- W2933152452 cites W2023424615 @default.
- W2933152452 cites W2045985937 @default.
- W2933152452 cites W2050983091 @default.
- W2933152452 cites W2057953361 @default.
- W2933152452 cites W2068142536 @default.
- W2933152452 cites W2069314780 @default.
- W2933152452 cites W2069421644 @default.
- W2933152452 cites W2069684901 @default.
- W2933152452 cites W2071521357 @default.
- W2933152452 cites W2080494915 @default.
- W2933152452 cites W2080592158 @default.
- W2933152452 cites W2083313236 @default.
- W2933152452 cites W2086756183 @default.
- W2933152452 cites W2088043742 @default.
- W2933152452 cites W2089050750 @default.
- W2933152452 cites W2101617798 @default.
- W2933152452 cites W2104010513 @default.
- W2933152452 cites W2107061457 @default.
- W2933152452 cites W2108387911 @default.
- W2933152452 cites W2109627278 @default.
- W2933152452 cites W2117532375 @default.
- W2933152452 cites W2119002242 @default.
- W2933152452 cites W2120352855 @default.
- W2933152452 cites W2148011592 @default.
- W2933152452 cites W2154041187 @default.
- W2933152452 cites W2168122777 @default.
- W2933152452 cites W2168241534 @default.
- W2933152452 cites W2185639560 @default.
- W2933152452 cites W2186794254 @default.
- W2933152452 cites W2395046586 @default.
- W2933152452 cites W2403542595 @default.
- W2933152452 cites W2487602222 @default.
- W2933152452 cites W2587484579 @default.
- W2933152452 cites W2783963698 @default.
- W2933152452 cites W2949374859 @default.
- W2933152452 doi "https://doi.org/10.1101/600841" @default.
- W2933152452 hasPublicationYear "2019" @default.
- W2933152452 type Work @default.
- W2933152452 sameAs 2933152452 @default.
- W2933152452 citedByCount "0" @default.
- W2933152452 crossrefType "posted-content" @default.
- W2933152452 hasAuthorship W2933152452A5003450706 @default.
- W2933152452 hasAuthorship W2933152452A5011256781 @default.
- W2933152452 hasAuthorship W2933152452A5019068409 @default.
- W2933152452 hasAuthorship W2933152452A5024146511 @default.
- W2933152452 hasAuthorship W2933152452A5030444472 @default.
- W2933152452 hasAuthorship W2933152452A5070407254 @default.
- W2933152452 hasAuthorship W2933152452A5070408333 @default.
- W2933152452 hasAuthorship W2933152452A5079202548 @default.
- W2933152452 hasAuthorship W2933152452A5086054108 @default.
- W2933152452 hasBestOaLocation W29331524521 @default.
- W2933152452 hasConcept C104317684 @default.
- W2933152452 hasConcept C105702510 @default.
- W2933152452 hasConcept C145103041 @default.
- W2933152452 hasConcept C15729860 @default.
- W2933152452 hasConcept C162407555 @default.
- W2933152452 hasConcept C168609215 @default.
- W2933152452 hasConcept C201750760 @default.
- W2933152452 hasConcept C207200792 @default.
- W2933152452 hasConcept C2777819096 @default.
- W2933152452 hasConcept C2779959927 @default.
- W2933152452 hasConcept C2780915607 @default.
- W2933152452 hasConcept C28328180 @default.
- W2933152452 hasConcept C3763915 @default.
- W2933152452 hasConcept C54355233 @default.