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• W2933163054 abstract "Recalcitrant dermatophytoses is on the rise. Though myriad factors contribute to recalcitrance including terbinafine resistance, itraconazole largely remains sensitive. However, there are increasing instances of patients not responding adequately to itraconazole despite low MICs, probably due to issues plaguing the pelletization process, resulting in suboptimal quality. Data on this topic was searched on pubmed using the search items: itraconazole, MIC, MFC, quality, assay, pharmacokinetics, pharmacodynamics, dermatophytoses, and recalcitrance. Areas covered: A detailed analysis of the manufacturing process of itraconazole with emphasis on pelletization and parameters affecting the dissolution and bioavailability is presented. Important formulation factors including drug-polymer ratio, polymer type, coating thickness, bead size, and number are discussed. Also covered is the rationale of dosimetry of itraconazole in dermatophytoses based on the skin pharmacokinetics and MIC of the organism. Expert opinion: The process of pelletization has multiple components aiming to achieve maximum dissolution of the drug. Variations in the process, pellet quality, number, and polymer determine absorption. Morphometric analysis of pellets is a simple method to quantify quality of the drug. Once the process has been standardized, dosimetry depends on the route of secretion and site of infection, accounting for the variation of doses from 100 mg to 400 mg/day." @default.
• W2933163054 created "2019-04-11" @default.
• W2933163054 creator A5002178980 @default.
• W2933163054 creator A5014300106 @default.
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• W2933163054 date "2019-04-22" @default.
• W2933163054 modified "2023-10-08" @default.
• W2933163054 title "Parameters that determine dissolution and efficacy of itraconazole and its relevance to recalcitrant dermatophytoses" @default.
• W2933163054 cites W1718541796 @default.
• W2933163054 cites W1773516461 @default.
• W2933163054 cites W1970421021 @default.
• W2933163054 cites W1972951148 @default.
• W2933163054 cites W1981693695 @default.
• W2933163054 cites W1984535516 @default.
• W2933163054 cites W1989518584 @default.
• W2933163054 cites W1989617949 @default.
• W2933163054 cites W1993334415 @default.
• W2933163054 cites W1996073950 @default.
• W2933163054 cites W2006558422 @default.
• W2933163054 cites W2007664861 @default.
• W2933163054 cites W2008116134 @default.
• W2933163054 cites W2010427019 @default.
• W2933163054 cites W2012066169 @default.
• W2933163054 cites W2016071165 @default.
• W2933163054 cites W2016971948 @default.
• W2933163054 cites W2019076404 @default.
• W2933163054 cites W2020508149 @default.
• W2933163054 cites W2021321721 @default.
• W2933163054 cites W2024934556 @default.
• W2933163054 cites W2036753807 @default.
• W2933163054 cites W2036889536 @default.
• W2933163054 cites W2041229610 @default.
• W2933163054 cites W2042744312 @default.
• W2933163054 cites W2043613676 @default.
• W2933163054 cites W2056211275 @default.
• W2933163054 cites W2056863521 @default.
• W2933163054 cites W2059496068 @default.
• W2933163054 cites W2065597699 @default.
• W2933163054 cites W2071913543 @default.
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• W2933163054 cites W2077489252 @default.
• W2933163054 cites W2078820986 @default.
• W2933163054 cites W2082707600 @default.
• W2933163054 cites W2085277141 @default.
• W2933163054 cites W2085792620 @default.
• W2933163054 cites W2093771030 @default.
• W2933163054 cites W2094040119 @default.
• W2933163054 cites W2095480328 @default.
• W2933163054 cites W2098304132 @default.
• W2933163054 cites W2104342617 @default.
• W2933163054 cites W2107580935 @default.
• W2933163054 cites W2110604072 @default.
• W2933163054 cites W2114727638 @default.
• W2933163054 cites W2119238594 @default.
• W2933163054 cites W2129449902 @default.
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• W2933163054 cites W2138070714 @default.
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• W2933163054 cites W2167642476 @default.
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• W2933163054 cites W2211313736 @default.
• W2933163054 cites W2261758620 @default.
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• W2933163054 cites W2309298288 @default.
• W2933163054 cites W2336601854 @default.
• W2933163054 cites W2419021252 @default.
• W2933163054 cites W2547416249 @default.
• W2933163054 cites W2604174381 @default.
• W2933163054 cites W2606841643 @default.
• W2933163054 cites W2606945242 @default.
• W2933163054 cites W2607807275 @default.
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• W2933163054 cites W2790356442 @default.
• W2933163054 cites W2790695048 @default.
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• W2933163054 cites W2951150727 @default.
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• W2933163054 doi "https://doi.org/10.1080/17512433.2019.1604218" @default.
• W2933163054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30952196" @default.
• W2933163054 hasPublicationYear "2019" @default.
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