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- W2933166524 abstract "Multiple sclerosis (MS) is a neuroinflammatory disease characterized bydemyelinated neurons in the central nervous system. Decreased levels of theanti-inflammatory microRNA-146a have previously been observed inmacrophages/microglia in MS patients compared to controls. Therapeuticallyelevating microRNA-146a expression in MS may produce a conduciveenvironment for remyelination. Inflammatory cytokines were assessed from bothprimary mouse and human macrophages and microglia, and THP-1macrophages that were transfected with a microRNA-146a mimic and polarizedtowards a pro-inflammatory phenotype. Inflammatory cytokines and MS-relevanttargets were measured following activation; neuro- and oligodendrogenesis werealso assessed in vitro while the effect of microRNA-146a on myelin phagocytosiswas also examined. MicroRNA-146a may decrease pro-inflammatory TNF butmay have little to no effect on IL-6; RhoA may decrease in both mouse andhuman macrophages. MicroRNA-146a increased myelin phagocytosis ofunstimulated primary mouse microglia. Finally, in vitro experiments suggest thatsupernatants collected from LPS-stimulated murine macrophages transfectedwith a microRNA-146a mimic do not affect neurogenesis or oligodendrogenesis.It is suggested that increasing microRNA-146a may promote an anti-inflammatoryenvironment beneficial for promoting remyelination in MS." @default.
- W2933166524 created "2019-04-11" @default.
- W2933166524 creator A5040574287 @default.
- W2933166524 date "2018-05-01" @default.
- W2933166524 modified "2023-09-24" @default.
- W2933166524 title "MicroRNA-146a: a potential therapeutic target in multiple sclerosis" @default.
- W2933166524 hasPublicationYear "2018" @default.
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