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- W2933243371 abstract "Pancreatic cancer (PDAC) is one of the most challenging cancers to treat with modest recent improvements in survival from new systemic therapies. There is growing interest in individualized therapy underpinned by somatic and germline genomic alterations.A systematic review of data on therapies targeting somatic and germline alterations, and their downstream pathways in PDAC.A systematic literature search was conducted using PRISMA guidelines to include relevant results published after January 1, 2008.A total of 71 relevant studies were included. We identified 36 studies targeting the KRAS-pathway, the most common being with MEK-inhibitor therapy. Twenty-two studies were identified that evaluated platinum-based chemotherapy and PARP inhibitors in patients with deleterious mutations in DNA damage repair genes and have shown encouraging results. Immunotherapy has demonstrated activity in patients with mismatch repair deficiency/microsatellite instability.Evidence from translational and clinical research presents an exciting platform for genomic targeted therapy in PDAC. Validity for targeting BRCA with platinum and PARP inhibitors and microsatellite instability with immune therapy has been established, nonetheless, evidence for targeting the common driver oncogenes is lacking and much work is needed. Of importance is identifying the subgroup of KRAS -wild type PDAC (approximately 5%) where there is enrichment for targetable opportunities." @default.
- W2933243371 created "2019-04-11" @default.
- W2933243371 creator A5009446517 @default.
- W2933243371 creator A5016800598 @default.
- W2933243371 creator A5018929455 @default.
- W2933243371 creator A5026453161 @default.
- W2933243371 creator A5027467209 @default.
- W2933243371 creator A5033315908 @default.
- W2933243371 date "2019-05-01" @default.
- W2933243371 modified "2023-10-12" @default.
- W2933243371 title "Genomic profiling in pancreatic ductal adenocarcinoma and a pathway towards therapy individualization: A scoping review" @default.
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