Matches in SemOpenAlex for { <https://semopenalex.org/work/W2933349257> ?p ?o ?g. }
- W2933349257 endingPage "842" @default.
- W2933349257 startingPage "835" @default.
- W2933349257 abstract "Abstract Vitamin D may affect cognitive performance, but previous studies are either short term or observational. We conducted a randomized controlled trial of vitamin D supplementation on domain-specific cognitive measures in postmenopausal women. Overweight/obese women with serum 25-hydroxyvitamin D (25OHD) levels less than 30 ng/mL were recruited. Vitamin D3 supplementation (600, 2,000, or 4,000 IU/d) was randomly assigned in a double-blinded manner for 1 year. Serum 25-hydroxyvitamin D, osteocalcin (total and undercarboxylated), amyloid beta, parathyroid hormone, and estradiol were analyzed before and after supplementation. Cognitive tests were administered after treatment. The women (58 ± 6 years; body mass index, 30.0 ± 3.5 kg/m2) had a baseline serum 25-hydroxyvitamin D level of 22.6 ± 5.8 ng/mL that increased to 30.2 ± 5.6, 36.0 ± 4.9, and 40.8 ± 7.0 ng/mL in the 600, 2,000, and 4,000 IU/d groups, respectively (p < .001). Participants taking 2,000 IU/d compared to other doses performed better in learning and memory tests (p < .05), yet the 4,000 IU/d group had a slower reaction time compared to the 600 IU/d group. Multiple regression indicated that serum undercarboxylated osteocalcin predicted tasks associated with reaction time and executive function, whereas body mass index and parathyroid hormone negatively predicted reaction time and executive function (p ≤ .01). These data suggest that vitamin D has differential effects on domain-specific cognitive measures and that a higher dose may negatively affect reaction time." @default.
- W2933349257 created "2019-04-11" @default.
- W2933349257 creator A5016009303 @default.
- W2933349257 creator A5033114528 @default.
- W2933349257 creator A5049200026 @default.
- W2933349257 creator A5052560444 @default.
- W2933349257 creator A5072338985 @default.
- W2933349257 creator A5081840607 @default.
- W2933349257 creator A5085708038 @default.
- W2933349257 creator A5088876204 @default.
- W2933349257 date "2019-02-14" @default.
- W2933349257 modified "2023-10-18" @default.
- W2933349257 title "Three Doses of Vitamin D and Cognitive Outcomes in Older Women: A Double-Blind Randomized Controlled Trial" @default.
- W2933349257 cites W1591177635 @default.
- W2933349257 cites W1605832277 @default.
- W2933349257 cites W1893905983 @default.
- W2933349257 cites W1966613471 @default.
- W2933349257 cites W1974604086 @default.
- W2933349257 cites W1977007818 @default.
- W2933349257 cites W2006440234 @default.
- W2933349257 cites W2012816790 @default.
- W2933349257 cites W2017975043 @default.
- W2933349257 cites W2025459091 @default.
- W2933349257 cites W2032288122 @default.
- W2933349257 cites W2046433564 @default.
- W2933349257 cites W2065184319 @default.
- W2933349257 cites W2078368771 @default.
- W2933349257 cites W2085187999 @default.
- W2933349257 cites W2093391499 @default.
- W2933349257 cites W2094484291 @default.
- W2933349257 cites W2096963202 @default.
- W2933349257 cites W2097101889 @default.
- W2933349257 cites W2098472276 @default.
- W2933349257 cites W2102537394 @default.
- W2933349257 cites W2107614626 @default.
- W2933349257 cites W2108014789 @default.
- W2933349257 cites W2108571742 @default.
- W2933349257 cites W2108594039 @default.
- W2933349257 cites W2112857078 @default.
- W2933349257 cites W2118236591 @default.
- W2933349257 cites W2119960796 @default.
- W2933349257 cites W2144217189 @default.
- W2933349257 cites W2147710843 @default.
- W2933349257 cites W2160802512 @default.
- W2933349257 cites W2165738353 @default.
- W2933349257 cites W2171086243 @default.
- W2933349257 cites W2212955848 @default.
- W2933349257 cites W2417430685 @default.
- W2933349257 cites W2496176059 @default.
- W2933349257 cites W2518325590 @default.
- W2933349257 cites W2584118005 @default.
- W2933349257 cites W2595859992 @default.
- W2933349257 cites W2610333344 @default.
- W2933349257 cites W2620777368 @default.
- W2933349257 cites W2740780484 @default.
- W2933349257 cites W2755155402 @default.
- W2933349257 cites W2761802341 @default.
- W2933349257 cites W2766085490 @default.
- W2933349257 cites W2806550409 @default.
- W2933349257 cites W407473455 @default.
- W2933349257 doi "https://doi.org/10.1093/gerona/glz041" @default.
- W2933349257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7164532" @default.
- W2933349257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30951148" @default.
- W2933349257 hasPublicationYear "2019" @default.
- W2933349257 type Work @default.
- W2933349257 sameAs 2933349257 @default.
- W2933349257 citedByCount "19" @default.
- W2933349257 countsByYear W29333492572019 @default.
- W2933349257 countsByYear W29333492572020 @default.
- W2933349257 countsByYear W29333492572021 @default.
- W2933349257 countsByYear W29333492572022 @default.
- W2933349257 countsByYear W29333492572023 @default.
- W2933349257 crossrefType "journal-article" @default.
- W2933349257 hasAuthorship W2933349257A5016009303 @default.
- W2933349257 hasAuthorship W2933349257A5033114528 @default.
- W2933349257 hasAuthorship W2933349257A5049200026 @default.
- W2933349257 hasAuthorship W2933349257A5052560444 @default.
- W2933349257 hasAuthorship W2933349257A5072338985 @default.
- W2933349257 hasAuthorship W2933349257A5081840607 @default.
- W2933349257 hasAuthorship W2933349257A5085708038 @default.
- W2933349257 hasAuthorship W2933349257A5088876204 @default.
- W2933349257 hasBestOaLocation W29333492572 @default.
- W2933349257 hasConcept C118552586 @default.
- W2933349257 hasConcept C124490489 @default.
- W2933349257 hasConcept C126322002 @default.
- W2933349257 hasConcept C131075544 @default.
- W2933349257 hasConcept C134018914 @default.
- W2933349257 hasConcept C160160445 @default.
- W2933349257 hasConcept C168563851 @default.
- W2933349257 hasConcept C169900460 @default.
- W2933349257 hasConcept C181199279 @default.
- W2933349257 hasConcept C185592680 @default.
- W2933349257 hasConcept C185711340 @default.
- W2933349257 hasConcept C2776940978 @default.
- W2933349257 hasConcept C2780221984 @default.
- W2933349257 hasConcept C2780586474 @default.
- W2933349257 hasConcept C2781208988 @default.
- W2933349257 hasConcept C519063684 @default.