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- W2933393190 abstract "Abstract Class F receptors, including the ten Frizzleds (FZD 1‐10 ) and SMO, mediate the effects of WNTs and hedgehog proteins and belong to the superfamily of G protein‐coupled receptors (GPCRs). While the recent, high‐resolution insight into mechanisms of GPCR activation provides a better understanding of receptor activation in Class A, B and C GPCRs, it remains unclear how Class F receptors bind their ligands, how ligand binding is translated to receptor activation and how signal initiation and specification are achieved. Here, we summarize recent efforts in elucidating Class F receptor structure and activation mechanisms and critically discuss the progress made in this area. A better understanding of the activation mechanisms of Class F receptors is required to engage in mechanism‐based and structure‐guided drug discovery to exploit the large therapeutic potential of targeting these receptors pharmacologically." @default.
- W2933393190 created "2019-04-11" @default.
- W2933393190 creator A5025877135 @default.
- W2933393190 creator A5060927839 @default.
- W2933393190 date "2019-04-21" @default.
- W2933393190 modified "2023-10-16" @default.
- W2933393190 title "Structural insight into Class F receptors – What have we learnt regarding agonist‐induced activation?" @default.
- W2933393190 cites W1594815607 @default.
- W2933393190 cites W1769151942 @default.
- W2933393190 cites W1825353903 @default.
- W2933393190 cites W1914882278 @default.
- W2933393190 cites W1918796765 @default.
- W2933393190 cites W1989971979 @default.
- W2933393190 cites W1997340548 @default.
- W2933393190 cites W1999126906 @default.
- W2933393190 cites W1999842541 @default.
- W2933393190 cites W2003620627 @default.
- W2933393190 cites W2008956402 @default.
- W2933393190 cites W2016877626 @default.
- W2933393190 cites W2018203300 @default.
- W2933393190 cites W2020601776 @default.
- W2933393190 cites W2036833206 @default.
- W2933393190 cites W2040182956 @default.
- W2933393190 cites W2043116643 @default.
- W2933393190 cites W2049230224 @default.
- W2933393190 cites W2051994079 @default.
- W2933393190 cites W2052091241 @default.
- W2933393190 cites W2059551149 @default.
- W2933393190 cites W2065431388 @default.
- W2933393190 cites W2065914048 @default.
- W2933393190 cites W2070524647 @default.
- W2933393190 cites W2078719550 @default.
- W2933393190 cites W2079796219 @default.
- W2933393190 cites W2090455515 @default.
- W2933393190 cites W2104477830 @default.
- W2933393190 cites W2104505841 @default.
- W2933393190 cites W2108981830 @default.
- W2933393190 cites W2111826622 @default.
- W2933393190 cites W2111889757 @default.
- W2933393190 cites W2114355635 @default.
- W2933393190 cites W2128801071 @default.
- W2933393190 cites W2136521447 @default.
- W2933393190 cites W2139129258 @default.
- W2933393190 cites W2141101632 @default.
- W2933393190 cites W2144558833 @default.
- W2933393190 cites W2163171072 @default.
- W2933393190 cites W2165775221 @default.
- W2933393190 cites W2167857702 @default.
- W2933393190 cites W2170498474 @default.
- W2933393190 cites W2189059614 @default.
- W2933393190 cites W2263779388 @default.
- W2933393190 cites W2337440865 @default.
- W2933393190 cites W2414254266 @default.
- W2933393190 cites W244037500 @default.
- W2933393190 cites W2467328988 @default.
- W2933393190 cites W2474599166 @default.
- W2933393190 cites W2499076660 @default.
- W2933393190 cites W2499343687 @default.
- W2933393190 cites W2504220478 @default.
- W2933393190 cites W2520075163 @default.
- W2933393190 cites W2524140863 @default.
- W2933393190 cites W2539886351 @default.
- W2933393190 cites W2559345010 @default.
- W2933393190 cites W2581167036 @default.
- W2933393190 cites W2589191033 @default.
- W2933393190 cites W2604323597 @default.
- W2933393190 cites W2607506319 @default.
- W2933393190 cites W2616201402 @default.
- W2933393190 cites W2618233912 @default.
- W2933393190 cites W2740216502 @default.
- W2933393190 cites W2756712429 @default.
- W2933393190 cites W2768177014 @default.
- W2933393190 cites W2775628882 @default.
- W2933393190 cites W2777807685 @default.
- W2933393190 cites W2788934957 @default.
- W2933393190 cites W2790984926 @default.
- W2933393190 cites W2791680789 @default.
- W2933393190 cites W2803451494 @default.
- W2933393190 cites W2809171792 @default.
- W2933393190 cites W2809303314 @default.
- W2933393190 cites W2809662941 @default.
- W2933393190 cites W2885011339 @default.
- W2933393190 cites W2885968097 @default.
- W2933393190 cites W2888670324 @default.
- W2933393190 cites W2891566522 @default.
- W2933393190 cites W2903412904 @default.
- W2933393190 cites W2913275192 @default.
- W2933393190 cites W61637776 @default.
- W2933393190 doi "https://doi.org/10.1111/bcpt.13235" @default.
- W2933393190 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30925000" @default.
- W2933393190 hasPublicationYear "2019" @default.
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