FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2933440064> ?p ?o ?g. }

• W2933440064 endingPage "2656" @default.
• W2933440064 startingPage "2644" @default.
• W2933440064 abstract "Lymph node (LN) metastasis occurs frequently in pancreatic ductal adenocarcinoma (PDAC), representing an advanced disease stage and independently predicting patient survival. Current nodal staging is inadequate preoperatively and even less so postoperatively, and molecular biomarkers are needed to improve prognostication and selection of therapy. Recent data have suggested important roles of miRNAs in PDAC tumorigenesis and progression. The aim of the present study was to identify miRNA expression signature for nodal spread in PDAC patients. Using PDAC human tissue specimens, we identified 39 miRNAs which were differently expressed in LN positive compared to LN negative PDAC samples. Of them, six miRNAs have been reported to play a role in cancer invasion and metastasis. A high versus low six- miRNA signature score was predictive of LN metastasis in the PDAC validation cohort. We demonstrated a similar expression pattern of four out of the six miRNAs in the plasma of PDAC patients. The results of our in-vitro studies revealed that miR-141 and miR-720 are involved in the process of epithelial to mesenchymal-transition in PDAC. These miRNAs significantly inhibited in vitro proliferation, migration and invasion of PDAC cells as evidence by gain- and loss- of function studies, specifically, via ZEB-1 and TWIST1 transcription factors, as well as through the activation of the MAP4K4/JNK signaling pathway." @default.
• W2933440064 created "2019-04-11" @default.
• W2933440064 creator A5001549786 @default.
• W2933440064 creator A5008721490 @default.
• W2933440064 creator A5026819897 @default.
• W2933440064 creator A5037650844 @default.
• W2933440064 creator A5045115112 @default.
• W2933440064 creator A5056872971 @default.
• W2933440064 creator A5072583520 @default.
• W2933440064 creator A5085260720 @default.
• W2933440064 date "2019-04-05" @default.
• W2933440064 modified "2023-09-27" @default.
• W2933440064 title "MicroRNA profiling of pancreatic ductal adenocarcinoma (PDAC) reveals signature expression related to lymph node metastasis" @default.
• W2933440064 cites W144423133 @default.
• W2933440064 cites W1648301895 @default.
• W2933440064 cites W1887150516 @default.
• W2933440064 cites W1964081206 @default.
• W2933440064 cites W1973903209 @default.
• W2933440064 cites W1974459801 @default.
• W2933440064 cites W1993021769 @default.
• W2933440064 cites W1994061059 @default.
• W2933440064 cites W2006797972 @default.
• W2933440064 cites W2008945738 @default.
• W2933440064 cites W2010704033 @default.
• W2933440064 cites W2011382807 @default.
• W2933440064 cites W2019214567 @default.
• W2933440064 cites W2021709978 @default.
• W2933440064 cites W2040431750 @default.
• W2933440064 cites W2047213909 @default.
• W2933440064 cites W2056909601 @default.
• W2933440064 cites W2057474195 @default.
• W2933440064 cites W2076583198 @default.
• W2933440064 cites W2083275514 @default.
• W2933440064 cites W2109166612 @default.
• W2933440064 cites W2115093090 @default.
• W2933440064 cites W2122724471 @default.
• W2933440064 cites W2137812732 @default.
• W2933440064 cites W2145263179 @default.
• W2933440064 cites W2146157095 @default.
• W2933440064 cites W2146729949 @default.
• W2933440064 cites W2152184695 @default.
• W2933440064 cites W2154589460 @default.
• W2933440064 cites W2155131748 @default.
• W2933440064 cites W2157615672 @default.
• W2933440064 cites W2170552969 @default.
• W2933440064 cites W2170989872 @default.
• W2933440064 cites W2171641698 @default.
• W2933440064 cites W2308134484 @default.
• W2933440064 cites W2397584071 @default.
• W2933440064 cites W2415018300 @default.
• W2933440064 cites W2428131591 @default.
• W2933440064 cites W2508859157 @default.
• W2933440064 cites W2524497551 @default.
• W2933440064 cites W2545902571 @default.
• W2933440064 cites W2556578483 @default.
• W2933440064 cites W2566915479 @default.
• W2933440064 cites W2589720086 @default.
• W2933440064 cites W2610145446 @default.
• W2933440064 cites W2699220065 @default.
• W2933440064 cites W2704414928 @default.
• W2933440064 cites W2744732242 @default.
• W2933440064 cites W2747815582 @default.
• W2933440064 cites W2751934900 @default.
• W2933440064 cites W2753109313 @default.
• W2933440064 cites W2755571637 @default.
• W2933440064 cites W2771780202 @default.
• W2933440064 cites W2774258350 @default.
• W2933440064 cites W2774734037 @default.
• W2933440064 cites W4210976084 @default.
• W2933440064 doi "https://doi.org/10.18632/oncotarget.26804" @default.
• W2933440064 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6498999" @default.
• W2933440064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31080555" @default.
• W2933440064 hasPublicationYear "2019" @default.
• W2933440064 type Work @default.
• W2933440064 sameAs 2933440064 @default.
• W2933440064 citedByCount "11" @default.
• W2933440064 countsByYear W29334400642019 @default.
• W2933440064 countsByYear W29334400642020 @default.
• W2933440064 countsByYear W29334400642021 @default.
• W2933440064 countsByYear W29334400642022 @default.
• W2933440064 countsByYear W29334400642023 @default.
• W2933440064 crossrefType "journal-article" @default.
• W2933440064 hasAuthorship W2933440064A5001549786 @default.
• W2933440064 hasAuthorship W2933440064A5008721490 @default.
• W2933440064 hasAuthorship W2933440064A5026819897 @default.
• W2933440064 hasAuthorship W2933440064A5037650844 @default.
• W2933440064 hasAuthorship W2933440064A5045115112 @default.
• W2933440064 hasAuthorship W2933440064A5056872971 @default.
• W2933440064 hasAuthorship W2933440064A5072583520 @default.
• W2933440064 hasAuthorship W2933440064A5085260720 @default.
• W2933440064 hasBestOaLocation W29334400641 @default.
• W2933440064 hasConcept C104317684 @default.
• W2933440064 hasConcept C121608353 @default.
• W2933440064 hasConcept C126322002 @default.
• W2933440064 hasConcept C142724271 @default.
• W2933440064 hasConcept C143998085 @default.
• W2933440064 hasConcept C145059251 @default.
• W2933440064 hasConcept C150194340 @default.

• next