Matches in SemOpenAlex for { <https://semopenalex.org/work/W2933447495> ?p ?o ?g. }
- W2933447495 abstract "Abstract Chronic pain is a common and severely disabling disease whose treatment is often unsatisfactory. Insights into the brain mechanisms of chronic pain promise to advance the understanding of the underlying pathophysiology and might help to develop disease markers and novel treatments. Here, we systematically and comprehensively exploited the potential of electroencephalography (EEG) to determine abnormalities of brain function during the resting state in chronic pain. To this end, we performed state-of-the-art analyses of oscillatory brain activity, brain connectivity and brain networks in 101 patients of either sex suffering from chronic pain. The results show that global and local measures of brain activity did not differ between chronic pain patients and a healthy control group. However, we observed significantly increased connectivity at theta (4 – 8 Hz) and gamma (> 60 Hz) frequencies in frontal brain areas as well as global network reorganization at gamma frequencies in chronic pain patients. Furthermore, a machine learning algorithm could differentiate between patients and healthy controls with an above-chance accuracy of 57%, mostly based on frontal connectivity. These results implicate increased theta and gamma synchrony in frontal brain areas in the pathophysiology of chronic pain. While substantial challenges concerning accuracy, specificity and validity of potential EEG-based disease markers remain to be overcome, our study identifies abnormal frontal synchrony at theta and gamma frequencies as promising targets for non-invasive brain stimulation and/or neurofeedback approaches." @default.
- W2933447495 created "2019-04-11" @default.
- W2933447495 creator A5000667313 @default.
- W2933447495 creator A5002502510 @default.
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- W2933447495 creator A5011936459 @default.
- W2933447495 creator A5014253359 @default.
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- W2933447495 creator A5030589169 @default.
- W2933447495 creator A5033891709 @default.
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- W2933447495 creator A5041362456 @default.
- W2933447495 creator A5056590166 @default.
- W2933447495 creator A5065026371 @default.
- W2933447495 date "2019-04-01" @default.
- W2933447495 modified "2023-09-26" @default.
- W2933447495 title "Brain dysfunction in chronic pain patients assessed by resting-state electroencephalography" @default.
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