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• W2933481844 abstract "Abstract This study aimed to evaluate the potential of long noncoding RNA s (lnc RNA s) as biomarkers for coronary artery disease ( CAD ). We measured the levels of three atherosclerosis‐ or cardiac‐related lnc RNA s in peripheral blood monocyte cells ( PBMC s) from 20 CAD patients and 20 non‐ CAD control participants using real‐time reverse transcription–polymerase chain reaction (real‐time RT – PCR ) methods. We found that the levels of lnc RNA KCNQ 1 opposite strand/antisense transcript 1 ( KCNQ 1 OT 1), hypoxia‐inducible factor 1 alpha‐antisense RNA 2 ( HIF 1A‐ AS 2) and apolipoprotein A‐1 antisense RNA ( APOA 1‐ AS ) were significantly increased in CAD patients ( KCNQ 1 OT 1 increased by 2.38‐fold, P = 0.00042; HIF 1A‐ AS 2 increased by 2.00‐fold, P = 0.0001; APOA 1‐ AS increased by 4.52‐fold, P = 0.000048). The area under the ROC curve was 0.865 for KCNQ 1 OT 1, 0.852 for HIF 1A‐ AS 2, and 0.967 for APOA 1‐ AS . Furthermore, the combination of lnc RNA s resulted in a much higher AUC value of 0.990 for the prediction of CAD . Spearman's correlation analysis showed that APOA 1‐ AS was positively correlated with NT ‐pro BNP , CKMB , MYO and HsTnT, whereas HIF 1A‐ AS 2 was correlated with NT ‐pro BNP and HsTnT. Hence, the elevation of KCNQ 1 OT 1, HIF 1A‐ AS 2 and APOA 1‐ AS predicts CAD and these molecules may be considered as novel biomarkers of CAD ." @default.
• W2933481844 created "2019-04-11" @default.
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• W2933481844 date "2019-04-29" @default.
• W2933481844 modified "2023-10-18" @default.
• W2933481844 title "<scp>KCNQ</scp> 1 <scp>OT</scp> 1, <scp>HIF</scp> 1A‐ <scp>AS</scp> 2 and <scp>APOA</scp> 1‐ <scp>AS</scp> are promising novel biomarkers for diagnosis of coronary artery disease" @default.
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• W2933481844 doi "https://doi.org/10.1111/1440-1681.13094" @default.
• W2933481844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30941792" @default.
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