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• W2933485329 abstract "Abstract Neonatally-developing, self-reactive B-1 cells generate steady levels natural antibodies throughout life. They can, however, also rapidly respond to infections with increased local antibody production. The mechanisms regulating these two seemingly very distinct functions are poorly understood, but have been linked to expression of CD5, an inhibitor of BCR-signaling. Here we demonstrate that TLR-mediated activation of CD5+ B-1 cells induced the rapid reorganization of the IgM-BCR complex, leading to the eventual loss of CD5 expression, and a concomitant increase in BCR-downstream signaling, both in vitro and in vivo after infections with influenza virus and Salmonella typhimurium . Both, initial CD5 expression and TLR-mediated stimulation, were required for the differentiation of B-1 cells to IgM-producing plasmablasts after infections. Thus, TLR-mediated signals support participation of B-1 cells in immune defense via BCR-complex reorganization." @default.
• W2933485329 created "2019-04-11" @default.
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• W2933485329 date "2019-04-02" @default.
• W2933485329 modified "2023-09-24" @default.
• W2933485329 title "TLR-induced reorganization of the IgM-BCR complex regulates B-1 cell responses to infections" @default.
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• W2933485329 doi "https://doi.org/10.1101/595694" @default.
• W2933485329 hasPublicationYear "2019" @default.
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