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- W2933594560 endingPage "2134" @default.
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- W2933594560 abstract "The evolution of interactions in the bovine serum albumin (BSA) protein solution on addition of mono and multivalent (di, tri and tetra) counterions has been studied using small-angle neutron scattering (SANS), dynamic light scattering (DLS) and ζ-potential measurements. It is found that in the presence of mono and divalent counterions, protein behavior can be well explained by DLVO theory, combining the contributions of screened Coulomb repulsion with the van der Waals attraction. The addition of mono or divalent salts in protein solution reduces the repulsive barrier and hence the overall interaction becomes attractive, but the system remains in one-phase for the entire concentration range of the salts, added in the system. However, contrary to DLVO theory, the protein solution undergoes a reentrant phase transition from one-phase to a two-phase system and then back to the one-phase system in the presence of tri and tetravalent counterions. The results show that tri and tetravalent (unlike mono and divalent) counterions induce short-range attraction between the protein molecules, leading to the transformation from one-phase to two-phase system. The two-phase is characterized by the fractal structure of protein aggregates. The excess condensation of these higher-valent counterions in the double layer around the BSA causes the reversal of charge of the protein molecules resulting into reentrant of the one-phase, at higher salt concentrations. The complete phase behavior with mono and multivalent ions has been explained in terms of the interplay of electrostatic repulsion and ion-induced short-range attraction between the protein molecules." @default.
- W2933594560 created "2019-04-11" @default.
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- W2933594560 date "2019-03-25" @default.
- W2933594560 modified "2023-09-26" @default.
- W2933594560 title "Evolution of Interactions in the Protein Solution As Induced by Mono and Multivalent Ions" @default.
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- W2933594560 doi "https://doi.org/10.1021/acs.biomac.9b00374" @default.
- W2933594560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30908911" @default.
- W2933594560 hasPublicationYear "2019" @default.
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