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• W2933642502 abstract "Abstract Age and severity are significant predictors of traumatic brain injury (TBI) outcomes in the immature brain. TBI studies have segregated TBI injury into three severity groups: mild, moderate, and severe. While mild TBI is most frequent form in children and adults, there is debate over the indicators used to denote mild injury. Clinically, magnetic resonance imaging (MRI) and computed tomography (CT) are used to diagnose the TBI severity when medically warranted. Herein, we induced mild, moderate, and severe TBI in juvenile rats (jTBI) using the controlled cortical impact model. We characterized the temporal and spatial injury after graded jTBI in vivo using high‐field MRI at 0.25 (6 hr), 1 and 3 days post‐injury (dpi) with comparative histology. Susceptibility‐weighted imaging (SWI) for blood and T2‐weighted imaging (T2WI) for edema were quantified over the 0.25–3 dpi. Edema volumes increased linearly with severity at 0.25 dpi that slowly continued to decrease over the 3 dpi. In contrast, blood volumes did not decrease over time. Mild TBI had the least amount of blood visible on SWI. Fluoro‐jade B (FJB) staining for cell death confirmed increased cellular death with increasing severity and increased FJB + cells in the corpus callosum (CC). Interestingly, the strongest correlation was observed for cell death and the presence of extravascular blood. A clear understanding of acute brain injury (jTBI) and how blood/edema contribute to mild, moderate, and severe jTBI is needed prior to embarking on therapeutic interventions. Noninvasive imaging should be used in mild jTBI to verify lack of overt injury." @default.
• W2933642502 created "2019-04-11" @default.
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• W2933642502 date "2019-03-27" @default.
• W2933642502 modified "2023-10-10" @default.
• W2933642502 title "Noninvasive magnetic resonance imaging stratifies injury severity in a rodent model of male juvenile traumatic brain injury" @default.
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• W2933642502 doi "https://doi.org/10.1002/jnr.24415" @default.
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• W2933642502 hasPublicationYear "2019" @default.
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