FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2933664897> ?p ?o ?g. }

• W2933664897 endingPage "179" @default.
• W2933664897 startingPage "171" @default.
• W2933664897 abstract "Beta-amyloid (Aβ) has pivotal functions in the pathogenesis of Alzheimer's Disease (AD). In the present study, we adopted an vitro model that involved Aβ25-35-induced oxidative damage in PC12 cells. Aβ25-35 (10 μΜ) treatment for 24 h induced significant cell death and oxidative stress in PC12 cells, as evidenced by cell viability reduction, LDH release, ROS accumulation and increased production MDA. (1E,4E)-1, 5-bis(4-hydroxy-3-methoxyphenyl) penta-1, 4-dien-3-one (CB) and (1E, 4E)-1-(3, 4-dimethoxyphenyl)-5-(4-hydroxy-3, 5-dime-thoxyphenyl) Penta-1, 4-dien-3-one (FE), two Curcumin (Cur) analogues displayed neuroprotective effects against Aβ25-35-induced oxidative damage and cellular apoptosis in PC12 cells. Here, we investigated three different treatment ways of CB and FE. It was interesting that post-treatment of CB and FE (restoring way) showed similar effect to the preventive way, while attenuating way did not show any protective effect. We found that low dose CB and FE increased transcriptional factor NF-E2-related factor 2 (Nrf2)/hemo oxygenase 1 (HO-1) protein expression and decreased Kelch-like ECH-associated protein 1 (Keap1) in PC 12 cells. In addition, CB and FE promoted the translation of Nrf2 into nuclear and enhanced the activity of superoxide dismutase (SOD)/catalase, which confirmed cytoprotection against Aβ25-35-induced oxidative damage. Moreover, CB and FE could increase Bcl-2 expression level, decrease the level of Bax and Cyt-c in Aβ25-35-treated PC12 cells. Ultimately, the neuroprotective effect of CB and FE provides a pharmacological basis for its clinical use in prevention and treatment of AD." @default.
• W2933664897 created "2019-04-11" @default.
• W2933664897 creator A5005350496 @default.
• W2933664897 creator A5008573195 @default.
• W2933664897 creator A5030314356 @default.
• W2933664897 creator A5035720806 @default.
• W2933664897 creator A5076103759 @default.
• W2933664897 date "2019-05-01" @default.
• W2933664897 modified "2023-10-03" @default.
• W2933664897 title "Curcumin analogues attenuate Aβ25-35-induced oxidative stress in PC12 cells via Keap1/Nrf2/HO-1 signaling pathways" @default.
• W2933664897 cites W1513524694 @default.
• W2933664897 cites W1558835554 @default.
• W2933664897 cites W1564406367 @default.
• W2933664897 cites W1949141569 @default.
• W2933664897 cites W1976194786 @default.
• W2933664897 cites W1990938604 @default.
• W2933664897 cites W1991327193 @default.
• W2933664897 cites W1991936623 @default.
• W2933664897 cites W1997149430 @default.
• W2933664897 cites W1997461746 @default.
• W2933664897 cites W1997887886 @default.
• W2933664897 cites W2004034281 @default.
• W2933664897 cites W2009278066 @default.
• W2933664897 cites W2011243629 @default.
• W2933664897 cites W2011375896 @default.
• W2933664897 cites W2015392958 @default.
• W2933664897 cites W2016777985 @default.
• W2933664897 cites W2018583377 @default.
• W2933664897 cites W2022387872 @default.
• W2933664897 cites W2036220732 @default.
• W2933664897 cites W2046078890 @default.
• W2933664897 cites W2056812738 @default.
• W2933664897 cites W2059404629 @default.
• W2933664897 cites W2062454567 @default.
• W2933664897 cites W2068659488 @default.
• W2933664897 cites W2115978010 @default.
• W2933664897 cites W2121515004 @default.
• W2933664897 cites W2123795043 @default.
• W2933664897 cites W2124634545 @default.
• W2933664897 cites W2135684059 @default.
• W2933664897 cites W2153767421 @default.
• W2933664897 cites W2155039139 @default.
• W2933664897 cites W2213679004 @default.
• W2933664897 cites W2222544782 @default.
• W2933664897 cites W2238003553 @default.
• W2933664897 cites W2343175315 @default.
• W2933664897 cites W2467527170 @default.
• W2933664897 cites W2473323600 @default.
• W2933664897 cites W2535730691 @default.
• W2933664897 cites W2605368176 @default.
• W2933664897 cites W2610806508 @default.
• W2933664897 cites W2767106718 @default.
• W2933664897 cites W2771203396 @default.
• W2933664897 doi "https://doi.org/10.1016/j.cbi.2019.01.010" @default.
• W2933664897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30946834" @default.
• W2933664897 hasPublicationYear "2019" @default.
• W2933664897 type Work @default.
• W2933664897 sameAs 2933664897 @default.
• W2933664897 citedByCount "44" @default.
• W2933664897 countsByYear W29336648972019 @default.
• W2933664897 countsByYear W29336648972020 @default.
• W2933664897 countsByYear W29336648972021 @default.
• W2933664897 countsByYear W29336648972022 @default.
• W2933664897 countsByYear W29336648972023 @default.
• W2933664897 crossrefType "journal-article" @default.
• W2933664897 hasAuthorship W2933664897A5005350496 @default.
• W2933664897 hasAuthorship W2933664897A5008573195 @default.
• W2933664897 hasAuthorship W2933664897A5030314356 @default.
• W2933664897 hasAuthorship W2933664897A5035720806 @default.
• W2933664897 hasAuthorship W2933664897A5076103759 @default.
• W2933664897 hasConcept C104317684 @default.
• W2933664897 hasConcept C185592680 @default.
• W2933664897 hasConcept C190283241 @default.
• W2933664897 hasConcept C25498285 @default.
• W2933664897 hasConcept C2775838275 @default.
• W2933664897 hasConcept C2776151105 @default.
• W2933664897 hasConcept C2776529522 @default.
• W2933664897 hasConcept C2778250585 @default.
• W2933664897 hasConcept C2778979269 @default.
• W2933664897 hasConcept C2780967304 @default.
• W2933664897 hasConcept C53227056 @default.
• W2933664897 hasConcept C55493867 @default.
• W2933664897 hasConcept C86339819 @default.
• W2933664897 hasConcept C86803240 @default.
• W2933664897 hasConcept C95444343 @default.
• W2933664897 hasConcept C98274493 @default.
• W2933664897 hasConceptScore W2933664897C104317684 @default.
• W2933664897 hasConceptScore W2933664897C185592680 @default.
• W2933664897 hasConceptScore W2933664897C190283241 @default.
• W2933664897 hasConceptScore W2933664897C25498285 @default.
• W2933664897 hasConceptScore W2933664897C2775838275 @default.
• W2933664897 hasConceptScore W2933664897C2776151105 @default.
• W2933664897 hasConceptScore W2933664897C2776529522 @default.
• W2933664897 hasConceptScore W2933664897C2778250585 @default.
• W2933664897 hasConceptScore W2933664897C2778979269 @default.
• W2933664897 hasConceptScore W2933664897C2780967304 @default.
• W2933664897 hasConceptScore W2933664897C53227056 @default.
• W2933664897 hasConceptScore W2933664897C55493867 @default.

• next