FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2933674804> ?p ?o ?g. }

• W2933674804 endingPage "844" @default.
• W2933674804 startingPage "830" @default.
• W2933674804 abstract "Background: Medullary thyroid carcinoma (MTC) presents a disproportionate number of thyroid cancer deaths due to limited treatment options beyond surgery. Gain-of-function mutations of the human REarranged during Transfection (RET) proto-oncogene have been well-established as the key driver of MTC tumorigenesis. RET has been targeted by tyrosine kinase inhibitors (TKIs), such as cabozantinib and vandetanib. However, clinical results have been disappointing, with regular dose reductions and inevitable progression. This study aimed to identify RET-regulated microRNAs (miRNAs) and explore their potential as novel therapeutic targets. Methods: Small RNA sequencing was performed in MTC TT cells before and after RET inhibition to identify RET-regulated miRNAs of significance. In vitro gain-of-function studies were performed to investigate cellular and molecular effects of potential miRNAs on cell phenotypes. Systemic delivery of miRNA in MTC xenografts using EDV™ nanocells, targeted to epidermal growth factor receptor on tumor cells, was employed to assess the therapeutic potential and possible modulation of TKI responses. Results: The study demonstrates the tumor suppressive role of a specific RET-regulated miRNA, microRNA-153-3p (miR-153-3p), in MTC. Targeted intravenous delivery of miR-153-3p impeded the tumor growth in MTC xenografts. Furthermore, combined treatment with miR-153-3p plus cabozantinib caused greater growth inhibition and appeared to reverse cabozantinib resistance. Mechanistically, miR-153-3p targets ribosomal protein S6 kinase B1 (RPS6KB1) of mTOR signaling and reduced downstream phosphorylation of Bcl-2 associated death promoter. Conclusion: This study provides evidence to establish systemic miRNA replacement plus TKIs as a novel therapeutic for patients with metastatic, progressive MTC." @default.
• W2933674804 created "2019-04-11" @default.
• W2933674804 creator A5001883661 @default.
• W2933674804 creator A5015490244 @default.
• W2933674804 creator A5016817473 @default.
• W2933674804 creator A5025077442 @default.
• W2933674804 creator A5026333487 @default.
• W2933674804 creator A5032098646 @default.
• W2933674804 creator A5032567530 @default.
• W2933674804 creator A5066999906 @default.
• W2933674804 creator A5087036316 @default.
• W2933674804 creator A5091652642 @default.
• W2933674804 date "2019-06-01" @default.
• W2933674804 modified "2023-10-07" @default.
• W2933674804 title "RET Kinase-Regulated MicroRNA-153-3p Improves Therapeutic Efficacy in Medullary Thyroid Carcinoma" @default.
• W2933674804 cites W1100378527 @default.
• W2933674804 cites W1508955841 @default.
• W2933674804 cites W1533533749 @default.
• W2933674804 cites W1594241115 @default.
• W2933674804 cites W1677557982 @default.
• W2933674804 cites W1697706524 @default.
• W2933674804 cites W1908870105 @default.
• W2933674804 cites W1937907895 @default.
• W2933674804 cites W1963747895 @default.
• W2933674804 cites W1969482148 @default.
• W2933674804 cites W1983718760 @default.
• W2933674804 cites W1985769983 @default.
• W2933674804 cites W1991487769 @default.
• W2933674804 cites W1991991004 @default.
• W2933674804 cites W1999596233 @default.
• W2933674804 cites W2004612295 @default.
• W2933674804 cites W2016304581 @default.
• W2933674804 cites W2020218669 @default.
• W2933674804 cites W2028942646 @default.
• W2933674804 cites W2034137384 @default.
• W2933674804 cites W2036254354 @default.
• W2933674804 cites W2055842662 @default.
• W2933674804 cites W2075229910 @default.
• W2933674804 cites W2075435981 @default.
• W2933674804 cites W2075543095 @default.
• W2933674804 cites W2083851097 @default.
• W2933674804 cites W2090368545 @default.
• W2933674804 cites W2096735709 @default.
• W2933674804 cites W2105813694 @default.
• W2933674804 cites W2116862985 @default.
• W2933674804 cites W2119501407 @default.
• W2933674804 cites W2122956665 @default.
• W2933674804 cites W2124808167 @default.
• W2933674804 cites W2142257207 @default.
• W2933674804 cites W2143350222 @default.
• W2933674804 cites W2144766937 @default.
• W2933674804 cites W2158219017 @default.
• W2933674804 cites W2159643242 @default.
• W2933674804 cites W2165275751 @default.
• W2933674804 cites W2165530442 @default.
• W2933674804 cites W2165799970 @default.
• W2933674804 cites W2172444147 @default.
• W2933674804 cites W2230916201 @default.
• W2933674804 cites W2333303928 @default.
• W2933674804 cites W2580759733 @default.
• W2933674804 cites W2604604487 @default.
• W2933674804 cites W2608433734 @default.
• W2933674804 cites W2614546816 @default.
• W2933674804 cites W2754975448 @default.
• W2933674804 cites W2757450081 @default.
• W2933674804 cites W2761566693 @default.
• W2933674804 cites W2766007895 @default.
• W2933674804 cites W2767788839 @default.
• W2933674804 cites W2769006626 @default.
• W2933674804 cites W2772515042 @default.
• W2933674804 cites W2778885300 @default.
• W2933674804 cites W2782032233 @default.
• W2933674804 cites W2794185618 @default.
• W2933674804 cites W2794930605 @default.
• W2933674804 cites W2800393195 @default.
• W2933674804 doi "https://doi.org/10.1089/thy.2018.0525" @default.
• W2933674804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30929576" @default.
• W2933674804 hasPublicationYear "2019" @default.
• W2933674804 type Work @default.
• W2933674804 sameAs 2933674804 @default.
• W2933674804 citedByCount "23" @default.
• W2933674804 countsByYear W29336748042019 @default.
• W2933674804 countsByYear W29336748042020 @default.
• W2933674804 countsByYear W29336748042021 @default.
• W2933674804 countsByYear W29336748042022 @default.
• W2933674804 countsByYear W29336748042023 @default.
• W2933674804 crossrefType "journal-article" @default.
• W2933674804 hasAuthorship W2933674804A5001883661 @default.
• W2933674804 hasAuthorship W2933674804A5015490244 @default.
• W2933674804 hasAuthorship W2933674804A5016817473 @default.
• W2933674804 hasAuthorship W2933674804A5025077442 @default.
• W2933674804 hasAuthorship W2933674804A5026333487 @default.
• W2933674804 hasAuthorship W2933674804A5032098646 @default.
• W2933674804 hasAuthorship W2933674804A5032567530 @default.
• W2933674804 hasAuthorship W2933674804A5066999906 @default.
• W2933674804 hasAuthorship W2933674804A5087036316 @default.
• W2933674804 hasAuthorship W2933674804A5091652642 @default.
• W2933674804 hasBestOaLocation W29336748041 @default.

• next