Matches in SemOpenAlex for { <https://semopenalex.org/work/W2933729420> ?p ?o ?g. }
- W2933729420 endingPage "65" @default.
- W2933729420 startingPage "54" @default.
- W2933729420 abstract "Doxorubicin (DOX) is one of the most effective chemotherapeutic drugs; however, the incidence of cardiotoxicity compromises its therapeutic index. Oxidative stress and apoptosis are believed to be involved in DOX-induced cardiotoxicity. Chitosan oligosaccharides (COS), the enzymatic hydrolysates of chitosan, have been reported to possess diverse biological activities including antioxidant and anti-apoptotic properties. The objective of the present study was to investigate the potential role of COS against DOX-induced cardiotoxicity, and the effects of COS on apoptosis and oxidative stress in rats and H9C2 cells. Furthermore, we also shed light on the involved pathways during the whole process. For this purpose, first, we demonstrated that COS exhibited a significant protective effect on cardiac tissue by not only inducing a decrease in body and heart growth but also ameliorated oxidative damage and ECG alterations in DOX-treated rats. Second, we found that COS reversed the decrease of cell viability induced by DOX, reduced the intracellular reactive oxygen species (ROS), increased the mitochondrial membrane potential (MMP) and Bcl-2/Bax ratio. COS treatment also results in reduced caspase-3 and caspase-9 expressions, and an increase in the phosphorylation of MAPKs (mitogen-activated protein kinases) in DOX-exposed H9C2 cells. Additionally, cellular homeostasis was re-established via stabilization of MAPK mediated nuclear factor erythroid 2-related factor 2/antioxidant-response element (Nrf2/ARE) signaling and transcription of downstream cytoprotective genes. In summary, these findings suggest that COS could be a potential candidate for the prevention and treatment of DOX-induced cardiotoxicity." @default.
- W2933729420 created "2019-04-11" @default.
- W2933729420 creator A5006157399 @default.
- W2933729420 creator A5008170491 @default.
- W2933729420 creator A5010724165 @default.
- W2933729420 creator A5031035876 @default.
- W2933729420 creator A5043211341 @default.
- W2933729420 creator A5086628644 @default.
- W2933729420 date "2019-05-01" @default.
- W2933729420 modified "2023-09-30" @default.
- W2933729420 title "Chitosan oligosaccharides prevent doxorubicin-induced oxidative stress and cardiac apoptosis through activating p38 and JNK MAPK mediated Nrf2/ARE pathway" @default.
- W2933729420 cites W1650319068 @default.
- W2933729420 cites W1967108243 @default.
- W2933729420 cites W1976478124 @default.
- W2933729420 cites W1985902621 @default.
- W2933729420 cites W1987837483 @default.
- W2933729420 cites W1997163515 @default.
- W2933729420 cites W2002138887 @default.
- W2933729420 cites W2009706695 @default.
- W2933729420 cites W2010242287 @default.
- W2933729420 cites W2012684233 @default.
- W2933729420 cites W2015315286 @default.
- W2933729420 cites W2021473035 @default.
- W2933729420 cites W2028243150 @default.
- W2933729420 cites W2031215262 @default.
- W2933729420 cites W2032191548 @default.
- W2933729420 cites W2036225919 @default.
- W2933729420 cites W2037918628 @default.
- W2933729420 cites W2044101767 @default.
- W2933729420 cites W2044498513 @default.
- W2933729420 cites W2047621839 @default.
- W2933729420 cites W2050829463 @default.
- W2933729420 cites W2054330377 @default.
- W2933729420 cites W2054601057 @default.
- W2933729420 cites W2055546060 @default.
- W2933729420 cites W2060043952 @default.
- W2933729420 cites W2067987000 @default.
- W2933729420 cites W2068100712 @default.
- W2933729420 cites W2068355621 @default.
- W2933729420 cites W2072140679 @default.
- W2933729420 cites W2079544758 @default.
- W2933729420 cites W2084229409 @default.
- W2933729420 cites W2089923455 @default.
- W2933729420 cites W2093311355 @default.
- W2933729420 cites W2095513409 @default.
- W2933729420 cites W2096000363 @default.
- W2933729420 cites W2102897174 @default.
- W2933729420 cites W2111426313 @default.
- W2933729420 cites W2112885253 @default.
- W2933729420 cites W2118422955 @default.
- W2933729420 cites W2122189144 @default.
- W2933729420 cites W2129739698 @default.
- W2933729420 cites W2140182328 @default.
- W2933729420 cites W2146521396 @default.
- W2933729420 cites W2146558971 @default.
- W2933729420 cites W2149386057 @default.
- W2933729420 cites W2154485147 @default.
- W2933729420 cites W2168049987 @default.
- W2933729420 cites W2288552312 @default.
- W2933729420 cites W2466710112 @default.
- W2933729420 cites W2538437447 @default.
- W2933729420 cites W2586749137 @default.
- W2933729420 cites W2608999444 @default.
- W2933729420 doi "https://doi.org/10.1016/j.cbi.2019.03.027" @default.
- W2933729420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30928397" @default.
- W2933729420 hasPublicationYear "2019" @default.
- W2933729420 type Work @default.
- W2933729420 sameAs 2933729420 @default.
- W2933729420 citedByCount "51" @default.
- W2933729420 countsByYear W29337294202019 @default.
- W2933729420 countsByYear W29337294202020 @default.
- W2933729420 countsByYear W29337294202021 @default.
- W2933729420 countsByYear W29337294202022 @default.
- W2933729420 countsByYear W29337294202023 @default.
- W2933729420 crossrefType "journal-article" @default.
- W2933729420 hasAuthorship W2933729420A5006157399 @default.
- W2933729420 hasAuthorship W2933729420A5008170491 @default.
- W2933729420 hasAuthorship W2933729420A5010724165 @default.
- W2933729420 hasAuthorship W2933729420A5031035876 @default.
- W2933729420 hasAuthorship W2933729420A5043211341 @default.
- W2933729420 hasAuthorship W2933729420A5086628644 @default.
- W2933729420 hasConcept C126322002 @default.
- W2933729420 hasConcept C178790620 @default.
- W2933729420 hasConcept C185592680 @default.
- W2933729420 hasConcept C190283241 @default.
- W2933729420 hasConcept C2776151105 @default.
- W2933729420 hasConcept C2776694085 @default.
- W2933729420 hasConcept C2778004101 @default.
- W2933729420 hasConcept C2778233292 @default.
- W2933729420 hasConcept C2781303535 @default.
- W2933729420 hasConcept C29730261 @default.
- W2933729420 hasConcept C48349386 @default.
- W2933729420 hasConcept C51551487 @default.
- W2933729420 hasConcept C55493867 @default.
- W2933729420 hasConcept C57074206 @default.
- W2933729420 hasConcept C62478195 @default.
- W2933729420 hasConcept C71924100 @default.
- W2933729420 hasConcept C86803240 @default.