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• W293376910 abstract "Publisher Summary This chapter discusses the localization of neurotrophins and their receptors at the mRNA and protein level. The nerve growth factor (NGF) family, commonly referred to as the neurotrophins and their receptors, encompasses eight different gene products, namely NGF, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT3), neurotrophin-4, the low-affinity neurotrophin receptor (LANR), and the high-affinity receptors trk, trk B and trk C. LANR mRNA is found in the somata of the long ascending cholinergic neurons with cell bodies in the medial septal nucleus, the diagonal band, and nucleus basalis. The high-affinity NGF receptor trk is expressed in the same set of cholinergic neurons. In addition, in scattered, presumably cholinergic neurons of striatum, trk B mRNA is abundantly present not only in the neurons of the brain including neurons that express BDNF message such as the majority of pyramidal and granular cells of the hippocampal formation and many cortical neurons but also neurons that do not contain BNDF mRNA. One truncated form of trk B lacking the intracellular signaling component appears to be abundantly present in non-neuronal cells such as glial cells in the hippocampal formation." @default.
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• W293376910 date "1994-01-01" @default.
• W293376910 modified "2023-10-02" @default.
• W293376910 title "Localization of Neurotrophins and Their Receptors at the mRNA and Protein Level" @default.
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• W293376910 doi "https://doi.org/10.1016/b978-0-08-042276-3.50012-4" @default.
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