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- W2933769162 abstract "Virus-induced cellular genetic modifications result in the development of many human cancers.In our experiments, we used the RVP3 cell line, which produce primary mouse virus-induced sarcoma in 100% of cases. Inbreed 4-week-old female C57BL/6 mice were injected subcutaneously in the interscapular region with RVP3 cells. Three groups of mice were used. For treatment, one and/or two intravenous injections of a complex of small non-coding RNAs (sncRNAs) a-miR-155, piR-30074, and miR-125b with a 2-diethylaminoethyl-dextran methyl methacrylate copolymer (DDMC) delivery system were used. The first group consisted of untreated animals (control). The second group was treated with one injection of complex DDMC/sncRNAs (1st group). The third group was treated with two injections of complex DDMC/sncRNAs (2nd group). The tumors were removed aseptically, freed of necrotic material, and used with spleen and lungs for subsequent RT-PCR and immunofluorescence experiments, or stained with Leishman-Romanowski dye.As a result, the mice fully recovered from virus-induced sarcoma after two treatments with a complex including the DDMC vector and a-miR-155, piR-30074, and miR-125b. In vitro studies showed genetic and morphological transformations of murine cancer cells after the injections.Treatment of virus-induced sarcoma of mice with a-miR-155, piR-30074, and miR-125b as active component of anti-cancer complex and DDMC vector as delivery system due to epigenetic-regulated transformation of cancer cells into cells with non-cancerous physiology and morphology and full recovery of disease." @default.
- W2933769162 created "2019-04-11" @default.
- W2933769162 creator A5006806817 @default.
- W2933769162 creator A5013332238 @default.
- W2933769162 date "2019-06-01" @default.
- W2933769162 modified "2023-10-17" @default.
- W2933769162 title "The full recovery of mice (Mus Musculus C57BL/6 strain) from virus–induced sarcoma after treatment with a complex of DDMC delivery system and sncRNAs" @default.
- W2933769162 cites W108367422 @default.
- W2933769162 cites W1503148643 @default.
- W2933769162 cites W1508066685 @default.
- W2933769162 cites W1548379836 @default.
- W2933769162 cites W1565039135 @default.
- W2933769162 cites W1883982053 @default.
- W2933769162 cites W1911562960 @default.
- W2933769162 cites W1966861889 @default.
- W2933769162 cites W1967324554 @default.
- W2933769162 cites W1969566546 @default.
- W2933769162 cites W1970698209 @default.
- W2933769162 cites W1974208791 @default.
- W2933769162 cites W1975811082 @default.
- W2933769162 cites W1977455794 @default.
- W2933769162 cites W1983322038 @default.
- W2933769162 cites W1988995678 @default.
- W2933769162 cites W1989900961 @default.
- W2933769162 cites W1992875306 @default.
- W2933769162 cites W1997883534 @default.
- W2933769162 cites W2003405179 @default.
- W2933769162 cites W2007829260 @default.
- W2933769162 cites W2012561960 @default.
- W2933769162 cites W2014878562 @default.
- W2933769162 cites W2026474914 @default.
- W2933769162 cites W2037215150 @default.
- W2933769162 cites W2038940805 @default.
- W2933769162 cites W2040534118 @default.
- W2933769162 cites W2041630873 @default.
- W2933769162 cites W2045228008 @default.
- W2933769162 cites W2045348184 @default.
- W2933769162 cites W2046837085 @default.
- W2933769162 cites W2049252550 @default.
- W2933769162 cites W2050869737 @default.
- W2933769162 cites W2050973237 @default.
- W2933769162 cites W2052064592 @default.
- W2933769162 cites W2064520719 @default.
- W2933769162 cites W2066710189 @default.
- W2933769162 cites W2074489774 @default.
- W2933769162 cites W2075243899 @default.
- W2933769162 cites W2082363749 @default.
- W2933769162 cites W2082526565 @default.
- W2933769162 cites W2087104878 @default.
- W2933769162 cites W2089485269 @default.
- W2933769162 cites W2092787906 @default.
- W2933769162 cites W2095110084 @default.
- W2933769162 cites W2096076362 @default.
- W2933769162 cites W2102675992 @default.
- W2933769162 cites W2108426094 @default.
- W2933769162 cites W2108502873 @default.
- W2933769162 cites W2108914190 @default.
- W2933769162 cites W2109377963 @default.
- W2933769162 cites W2112192177 @default.
- W2933769162 cites W2114298461 @default.
- W2933769162 cites W2116706835 @default.
- W2933769162 cites W2118126511 @default.
- W2933769162 cites W2118420574 @default.
- W2933769162 cites W2120208667 @default.
- W2933769162 cites W2120689337 @default.
- W2933769162 cites W2125155400 @default.
- W2933769162 cites W2128733367 @default.
- W2933769162 cites W2131974188 @default.
- W2933769162 cites W2133444435 @default.
- W2933769162 cites W2133934711 @default.
- W2933769162 cites W2134697926 @default.
- W2933769162 cites W2135380694 @default.
- W2933769162 cites W2149544405 @default.
- W2933769162 cites W2149850403 @default.
- W2933769162 cites W2153936208 @default.
- W2933769162 cites W2162319521 @default.
- W2933769162 cites W2163199119 @default.
- W2933769162 cites W2163985885 @default.
- W2933769162 cites W2167671211 @default.
- W2933769162 cites W2168205469 @default.
- W2933769162 cites W2172932999 @default.
- W2933769162 cites W2197991419 @default.
- W2933769162 cites W2221944044 @default.
- W2933769162 cites W2234938965 @default.
- W2933769162 cites W2257993531 @default.
- W2933769162 cites W2279483750 @default.
- W2933769162 cites W2330271147 @default.
- W2933769162 cites W2346891101 @default.
- W2933769162 cites W2397281987 @default.
- W2933769162 cites W2409528797 @default.
- W2933769162 cites W2411724331 @default.
- W2933769162 cites W2416081512 @default.
- W2933769162 cites W2417845078 @default.
- W2933769162 cites W2462064254 @default.
- W2933769162 cites W2559239118 @default.
- W2933769162 cites W2561287160 @default.
- W2933769162 cites W2587242538 @default.
- W2933769162 cites W2606673249 @default.