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- W293377079 abstract "Considering the anatomical localization of bone and bone marrow it is not surprising that both tissues are composed of cells from hematopoietic as well as from stromal origin. Indeed, apart from the stroma-derived osteoblasts and osteocytes, which are characterized by their ability to produce a mineralized matrix1,2 bone also contains osteoclasts. Osteoclasts belong to the hematopoietic lineage and have a lot in common with macrophages and characteristically resorb bone.3,4 The hematopoietic compartment of the bone marrow on the other hand, is functionally and structurally supported by a microenvironment of stromal elements including adipocytes, fibroblasts, endothelial cells and undifferentiated mesenchymal cells. These mesenchymal cells represent a reservoir of “uncommitted”, self-renewing cells which differentiate into various stromal elements, including bone.2,5 Under normal conditions, hematopoiesis and stromal differentiation require complex sequences of cellular events that are modulated by site-specific and cell-specific signals capable of initializing and promoting the recruitment and proliferation of the appropriate cells at the right time. These signals are mediated by hormones, prostaglandins, growth factors and cytokines which either reside in the bone matrix or in the bone marrow. The goal of this chapter is to review the effects of interleukin-10 (IL-10) on bone formation and hematopoiesis. IL-10 was initially described as cytokine synthesis inhibiting factor (CSIF) based on its potential to block the synthesis of cytokines produced by type 2 helper T cells.6" @default.
- W293377079 created "2016-06-24" @default.
- W293377079 creator A5051303348 @default.
- W293377079 date "1995-01-01" @default.
- W293377079 modified "2023-09-23" @default.
- W293377079 title "IL-10 and Bone Formation/Hematopoiesis" @default.
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- W293377079 doi "https://doi.org/10.1007/978-3-662-22038-2_7" @default.
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