FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2933870156> ?p ?o ?g. }

• W2933870156 endingPage "111844" @default.
• W2933870156 startingPage "111844" @default.
• W2933870156 abstract "Several traditional medicinal herbs are widely used for dermatologic and cosmetic preparations. The beneficial skin repair activity is detected in various phases of wound-healing process, such as cell-cell, cell-matrix interactions or collagen synthesis. Aim Of The Study: The study assessed the effects of Opuntia ficus-indica (L.) Mill. (Opuntia) and Milk Thistle (MT) (Silybum marianum (L.) Gaerth) on adult keratinocytes (HaCaT) functioning under basal condition or in the presence of mechanical damage (wounded cells). The role of the natural compounds was tested on HaCaT grown in mono-culture and tri-culture configurations. In tri-cultures models, HaCaT were treated with the conditioned media (CM) obtained by Human Normal Dermal Fibroblast (NHDF) and Human Dermal Microvascular Endothelial cells (HMVEC) co-cultures. Specifically, were tested cell viability, oxidative stress mechanisms (cytokines release and lipid peroxidation) and cellular remodelling (growth factors release or metalloproteinase modulation). Moreover, the migratory potential of HaCaT was analysed by the use of wound healing in vitro assay. Opuntia and MT differently modified the metabolism (EGF, MMP-9), and the migratory properties of HaCaT both under physiological conditions or upon mechanical damage (wounded cells). Moreover, both compounds modulated HaCaT response to oxidative stress. The response to the natural compounds were modified, and in some cases potentiated, in tri-culture configuration systems. The data demonstrated that in vitro tri-culture approach is suitable to characterize the role of natural compounds on the complex communication between dermal-epidermal cellular components and microvascular endothelium. Specifically, Opuntia and MT are good alternatives to synthetic compounds in skin repair promotion." @default.
• W2933870156 created "2019-04-11" @default.
• W2933870156 creator A5003960965 @default.
• W2933870156 creator A5017017972 @default.
• W2933870156 creator A5059836069 @default.
• W2933870156 date "2019-06-01" @default.
• W2933870156 modified "2023-09-30" @default.
• W2933870156 title "Natural dietary antioxidants containing flavonoids modulate keratinocytes physiology: In vitro tri-culture models" @default.
• W2933870156 cites W1124090844 @default.
• W2933870156 cites W1911635130 @default.
• W2933870156 cites W1965467877 @default.
• W2933870156 cites W1973057304 @default.
• W2933870156 cites W1986456879 @default.
• W2933870156 cites W1994574787 @default.
• W2933870156 cites W1995976759 @default.
• W2933870156 cites W2003808348 @default.
• W2933870156 cites W2025894730 @default.
• W2933870156 cites W2033992361 @default.
• W2933870156 cites W2034520784 @default.
• W2933870156 cites W2036471655 @default.
• W2933870156 cites W2043992157 @default.
• W2933870156 cites W2056294188 @default.
• W2933870156 cites W2065246445 @default.
• W2933870156 cites W2076234023 @default.
• W2933870156 cites W2080453950 @default.
• W2933870156 cites W2084916558 @default.
• W2933870156 cites W2084991458 @default.
• W2933870156 cites W2092150444 @default.
• W2933870156 cites W2095405108 @default.
• W2933870156 cites W2098475269 @default.
• W2933870156 cites W2111995897 @default.
• W2933870156 cites W2132886980 @default.
• W2933870156 cites W2136941442 @default.
• W2933870156 cites W2152644597 @default.
• W2933870156 cites W2157594132 @default.
• W2933870156 cites W2417125126 @default.
• W2933870156 cites W2521281050 @default.
• W2933870156 cites W2534347130 @default.
• W2933870156 cites W2765287340 @default.
• W2933870156 doi "https://doi.org/10.1016/j.jep.2019.111844" @default.
• W2933870156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30940568" @default.
• W2933870156 hasPublicationYear "2019" @default.
• W2933870156 type Work @default.
• W2933870156 sameAs 2933870156 @default.
• W2933870156 citedByCount "7" @default.
• W2933870156 countsByYear W29338701562020 @default.
• W2933870156 countsByYear W29338701562021 @default.
• W2933870156 countsByYear W29338701562022 @default.
• W2933870156 countsByYear W29338701562023 @default.
• W2933870156 crossrefType "journal-article" @default.
• W2933870156 hasAuthorship W2933870156A5003960965 @default.
• W2933870156 hasAuthorship W2933870156A5017017972 @default.
• W2933870156 hasAuthorship W2933870156A5059836069 @default.
• W2933870156 hasBestOaLocation W29338701562 @default.
• W2933870156 hasConcept C118995209 @default.
• W2933870156 hasConcept C185592680 @default.
• W2933870156 hasConcept C202751555 @default.
• W2933870156 hasConcept C203014093 @default.
• W2933870156 hasConcept C2776151105 @default.
• W2933870156 hasConcept C2777074287 @default.
• W2933870156 hasConcept C2778005187 @default.
• W2933870156 hasConcept C2780210117 @default.
• W2933870156 hasConcept C2780269544 @default.
• W2933870156 hasConcept C2780381497 @default.
• W2933870156 hasConcept C2780829032 @default.
• W2933870156 hasConcept C53227056 @default.
• W2933870156 hasConcept C54355233 @default.
• W2933870156 hasConcept C55493867 @default.
• W2933870156 hasConcept C59822182 @default.
• W2933870156 hasConcept C81885089 @default.
• W2933870156 hasConcept C86803240 @default.
• W2933870156 hasConcept C95444343 @default.
• W2933870156 hasConcept C98274493 @default.
• W2933870156 hasConceptScore W2933870156C118995209 @default.
• W2933870156 hasConceptScore W2933870156C185592680 @default.
• W2933870156 hasConceptScore W2933870156C202751555 @default.
• W2933870156 hasConceptScore W2933870156C203014093 @default.
• W2933870156 hasConceptScore W2933870156C2776151105 @default.
• W2933870156 hasConceptScore W2933870156C2777074287 @default.
• W2933870156 hasConceptScore W2933870156C2778005187 @default.
• W2933870156 hasConceptScore W2933870156C2780210117 @default.
• W2933870156 hasConceptScore W2933870156C2780269544 @default.
• W2933870156 hasConceptScore W2933870156C2780381497 @default.
• W2933870156 hasConceptScore W2933870156C2780829032 @default.
• W2933870156 hasConceptScore W2933870156C53227056 @default.
• W2933870156 hasConceptScore W2933870156C54355233 @default.
• W2933870156 hasConceptScore W2933870156C55493867 @default.
• W2933870156 hasConceptScore W2933870156C59822182 @default.
• W2933870156 hasConceptScore W2933870156C81885089 @default.
• W2933870156 hasConceptScore W2933870156C86803240 @default.
• W2933870156 hasConceptScore W2933870156C95444343 @default.
• W2933870156 hasConceptScore W2933870156C98274493 @default.
• W2933870156 hasLocation W29338701561 @default.
• W2933870156 hasLocation W29338701562 @default.
• W2933870156 hasLocation W29338701563 @default.
• W2933870156 hasOpenAccess W2933870156 @default.
• W2933870156 hasPrimaryLocation W29338701561 @default.
• W2933870156 hasRelatedWork W2015865696 @default.

• next