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- W2933943008 abstract "Abstract Breast and prostate cancers are frequently treated with chemotherapy. Several novel chemicals are being reported for this purpose, particularly synthetic and natural benzophenones. This work reports the synthesis of substituted 2‐hydroxybenzophenones through 1,4‐conjugate addition/intramolecular cycloaddition/dehydration of nitromethane on key intermediate chromones. Structures were extensively studied by means of 2D NMR spectroscopy and single‐crystal XRD. Their cytotoxicity was evaluated in vitro in two breast cancer cell lines (MDA‐MB‐231 and T47‐D) and one prostate cancer cell line (PC3). The most potent compound exhibited good cytotoxic effects against the three cancer cell lines (IC 50 values ranging from 12.09 to 26.49 μ m ) and induced cell‐cycle retardation only on prostate cancer cells, which suggested that it might exert cell‐type‐specific effects." @default.
- W2933943008 created "2019-04-11" @default.
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- W2933943008 date "2019-04-24" @default.
- W2933943008 modified "2023-10-16" @default.
- W2933943008 title "Synthesis of Benzophenones and in vitro Evaluation of Their Anticancer Potential in Breast and Prostate Cancer Cells" @default.
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- W2933943008 doi "https://doi.org/10.1002/cmdc.201900127" @default.
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