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• W2934094990 abstract "Objectives We aimed to assess the characteristics, outcomes and costs of septic shock complicating Systemic Lupus Erythematosus (SLE). Methods Characteristics of SLE patients experiencing a septic shock in France from 2010 to 2015 were analyzed through the French medico-administrative database. Factors associated with the 1-year post-admission mortality were analyzed, the crude 1-year survival of SLE patients experiencing septic shock was compared to those admitted for another reason, and we compared the 1-year outcome associated with SLE septic shock survival to a matched SLE ICU control population. Results Among 28,522 SLE patients, 1068 experienced septic shock. The 1-year mortality rate was 43.4%. Independently of the severity, an associated Sjögren syndrome was the only specific SLE phenotype associated with mortality (HR 1.392[1.021–1.899]). Within one year, post-septic shock survivors (n = 738) were re-admitted 6.42[17.3] times with total cost of € 14,431[20,444]. Unmatched analysis showed that the outcome of patients admitted in ICU for septic shock was poorer than that of patients admitted in ICU or hospital for another disease. However, 1-year healthcare use of septic shock survivors was not different from the other ICU survivors when matched on severity. Conclusions Septic shock is a frequent and severe complication among SLE patients even if it is not associated with more healthcare use than another episode of same severity." @default.
• W2934094990 created "2019-04-11" @default.
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• W2934094990 date "2019-06-01" @default.
• W2934094990 modified "2023-10-17" @default.
• W2934094990 title "Septic shock among patients with systemic lupus erythematosus: Short and long-term outcome. Analysis of a French nationwide database" @default.
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• W2934094990 doi "https://doi.org/10.1016/j.jinf.2019.04.005" @default.
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