FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2934176564> ?p ?o ?g. }

• W2934176564 abstract "Merkel cell carcinoma has historically had dismal prognosis with limited cytotoxic chemotherapy options that provide durable control of metastatic disease. The advent of anti-programmed death protein (anti-PD1)/anti-programmed death-ligand 1 (anti-PD-L1) directed immunotherapy has shown initial promise in Merkel cell carcinoma and radiation might augment immune responses. We present a case report of a 70-year-old male who underwent resection of Merkel cell carcinoma of the right thigh with a close margin and positive right inguinal involvement. Due to high-risk features, the patient was treated with adjuvant radiation to the right groin and with systemic carboplatin/etoposide, but developed local failure requiring salvage surgical resection. The patient then developed metastatic disease with biopsy proven retroperitoneal involvement refractory to doxorubicin/cyclophosphamide chemotherapy. The patient was then transitioned to single-agent pembrolizumab with a partial response for 10 months until developing progressive disease involving the left inguinal and left external iliac nodal regions. The progressive left inguinal/pelvic disease was treated with conventionally fractionated intensity modulated radiation therapy to a dose of 45 Gy delivered in 25 fractions. Following radiation therapy, the patient had complete response of all sites of disease throughout the body by RECIST criteria. At 20 months post-radiation, the patient remains on pembrolizumab without evidence of disease on imaging. Herein, we present a case of durable abscopal response of metastatic Merkel cell carcinoma treated with concurrent radiation and pembrolizumab, providing evidence that radiation might improve systemic responses to anti-PD1/PD-L1 directed immune therapy. Ongoing prospective trials evaluating the utility of radiation in conjunction with immunotherapy for Merkel cell carcinoma are anticipated to provide clarity on the frequency and durability of abscopal responses when radiation is combined with immune checkpoint inhibitors." @default.
• W2934176564 created "2019-04-11" @default.
• W2934176564 creator A5004497069 @default.
• W2934176564 creator A5012745900 @default.
• W2934176564 creator A5020297880 @default.
• W2934176564 creator A5024203346 @default.
• W2934176564 creator A5027029651 @default.
• W2934176564 creator A5038782400 @default.
• W2934176564 creator A5039854961 @default.
• W2934176564 creator A5055476105 @default.
• W2934176564 creator A5066698956 @default.
• W2934176564 creator A5070769370 @default.
• W2934176564 creator A5085763839 @default.
• W2934176564 date "2019-04-05" @default.
• W2934176564 modified "2023-10-13" @default.
• W2934176564 title "Rescue of Immunotherapy-Refractory Metastatic Merkel Cell Carcinoma With Conventionally Fractionated Radiotherapy and Concurrent Pembrolizumab" @default.
• W2934176564 cites W1965730378 @default.
• W2934176564 cites W1966007866 @default.
• W2934176564 cites W1982110587 @default.
• W2934176564 cites W1984054147 @default.
• W2934176564 cites W2025421597 @default.
• W2934176564 cites W2085487956 @default.
• W2934176564 cites W2127733313 @default.
• W2934176564 cites W2155263737 @default.
• W2934176564 cites W2171480930 @default.
• W2934176564 cites W2280306471 @default.
• W2934176564 cites W2283046649 @default.
• W2934176564 cites W2339890238 @default.
• W2934176564 cites W2498543837 @default.
• W2934176564 cites W2624275086 @default.
• W2934176564 cites W2766831098 @default.
• W2934176564 cites W2772726308 @default.
• W2934176564 cites W2783234388 @default.
• W2934176564 cites W2790524025 @default.
• W2934176564 cites W2806816360 @default.
• W2934176564 cites W2811086367 @default.
• W2934176564 doi "https://doi.org/10.3389/fonc.2019.00223" @default.
• W2934176564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6459944" @default.
• W2934176564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31024834" @default.
• W2934176564 hasPublicationYear "2019" @default.
• W2934176564 type Work @default.
• W2934176564 sameAs 2934176564 @default.
• W2934176564 citedByCount "20" @default.
• W2934176564 countsByYear W29341765642019 @default.
• W2934176564 countsByYear W29341765642020 @default.
• W2934176564 countsByYear W29341765642021 @default.
• W2934176564 countsByYear W29341765642022 @default.
• W2934176564 countsByYear W29341765642023 @default.
• W2934176564 crossrefType "journal-article" @default.
• W2934176564 hasAuthorship W2934176564A5004497069 @default.
• W2934176564 hasAuthorship W2934176564A5012745900 @default.
• W2934176564 hasAuthorship W2934176564A5020297880 @default.
• W2934176564 hasAuthorship W2934176564A5024203346 @default.
• W2934176564 hasAuthorship W2934176564A5027029651 @default.
• W2934176564 hasAuthorship W2934176564A5038782400 @default.
• W2934176564 hasAuthorship W2934176564A5039854961 @default.
• W2934176564 hasAuthorship W2934176564A5055476105 @default.
• W2934176564 hasAuthorship W2934176564A5066698956 @default.
• W2934176564 hasAuthorship W2934176564A5070769370 @default.
• W2934176564 hasAuthorship W2934176564A5085763839 @default.
• W2934176564 hasBestOaLocation W29341765641 @default.
• W2934176564 hasConcept C121608353 @default.
• W2934176564 hasConcept C126322002 @default.
• W2934176564 hasConcept C141071460 @default.
• W2934176564 hasConcept C143998085 @default.
• W2934176564 hasConcept C2776694085 @default.
• W2934176564 hasConcept C2777546739 @default.
• W2934176564 hasConcept C2777701055 @default.
• W2934176564 hasConcept C2778239845 @default.
• W2934176564 hasConcept C2778342957 @default.
• W2934176564 hasConcept C2780057760 @default.
• W2934176564 hasConcept C2781274730 @default.
• W2934176564 hasConcept C2781451048 @default.
• W2934176564 hasConcept C509974204 @default.
• W2934176564 hasConcept C71924100 @default.
• W2934176564 hasConceptScore W2934176564C121608353 @default.
• W2934176564 hasConceptScore W2934176564C126322002 @default.
• W2934176564 hasConceptScore W2934176564C141071460 @default.
• W2934176564 hasConceptScore W2934176564C143998085 @default.
• W2934176564 hasConceptScore W2934176564C2776694085 @default.
• W2934176564 hasConceptScore W2934176564C2777546739 @default.
• W2934176564 hasConceptScore W2934176564C2777701055 @default.
• W2934176564 hasConceptScore W2934176564C2778239845 @default.
• W2934176564 hasConceptScore W2934176564C2778342957 @default.
• W2934176564 hasConceptScore W2934176564C2780057760 @default.
• W2934176564 hasConceptScore W2934176564C2781274730 @default.
• W2934176564 hasConceptScore W2934176564C2781451048 @default.
• W2934176564 hasConceptScore W2934176564C509974204 @default.
• W2934176564 hasConceptScore W2934176564C71924100 @default.
• W2934176564 hasLocation W29341765641 @default.
• W2934176564 hasLocation W29341765642 @default.
• W2934176564 hasLocation W29341765643 @default.
• W2934176564 hasLocation W29341765644 @default.
• W2934176564 hasOpenAccess W2934176564 @default.
• W2934176564 hasPrimaryLocation W29341765641 @default.
• W2934176564 hasRelatedWork W1718066741 @default.
• W2934176564 hasRelatedWork W2131322929 @default.
• W2934176564 hasRelatedWork W2585407512 @default.
• W2934176564 hasRelatedWork W2598017149 @default.
• W2934176564 hasRelatedWork W2891524425 @default.

• next