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- W2934291275 abstract "Background: HIV-infected (HIV+) women seem to be more vulnerable to neurocognitive impairment (NCI) than HIV+ men, perhaps in part due to mental health factors. We assessed the association between elevated depressive symptoms and NCI among HIV+ and HIV-uninfected (HIV−) women and men. Setting: Women's Interagency HIV Study and Multicenter AIDS Cohort Study. Methods: Eight hundred fifty-eight HIV+ (429 women; 429 men) and 562 HIV− (281 women; 281 men) completed the Center for Epidemiologic Studies Depression (16 cutoff) Scale and measures of psychomotor speed/attention, executive, and motor function over multiple visits (or time points). Women's Interagency HIV Study and Multicenter AIDS Cohort Study participants were matched according to HIV status, age, race/ethnicity, and education. Generalized linear mixed models were used to examine interactions between biological sex, HIV serostatus, and depression on impairment (T-scores <40) after covariate adjustment. Results: Despite a higher frequency of depression among men, the association between depression and executive function differed by sex and HIV serostatus. HIV+ women with depression had 5 times the odds of impairment on a measure of executive control and inhibition versus HIV− depressed women and 3 times the odds of impairment on that measure versus HIV+ depressed men. Regardless of group status, depression was associated with greater impairment on processing speed, executive (mental flexibility), and motor function ( P 's < 0.05). Conclusions: Depression contributes to NCI across a broad range of cognitive domains in HIV+ and HIV− individuals, but HIV+ depressed women show greater vulnerabilities in executive function. Treating depression may help to improve cognition in patients with HIV infection." @default.
- W2934291275 created "2019-04-11" @default.
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- W2934291275 date "2019-07-01" @default.
- W2934291275 modified "2023-10-16" @default.
- W2934291275 title "Elevated Depressive Symptoms Are a Stronger Predictor of Executive Dysfunction in HIV-Infected Women Than in Men" @default.
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- W2934291275 doi "https://doi.org/10.1097/qai.0000000000002029" @default.
- W2934291275 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7254882" @default.
- W2934291275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30893126" @default.
- W2934291275 hasPublicationYear "2019" @default.
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