FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2934548328> ?p ?o ?g. }

• W2934548328 abstract "Ever since the discovery of thyroid hormone deficiency as the primary cause of cretinism in the second half of the 19th century, the crucial role of thyroid hormone (TH) signaling in embryonic brain development has been established. However, the biological understanding of TH function in brain formation is far from complete, despite advances in treating thyroid function deficiency disorders. The pleiotropic nature of TH action makes it difficult to identify and study discrete roles of TH in various aspect of embryogenesis, including neurogenesis and brain maturation. These challenges notwithstanding, enormous progress has been achieved in understanding TH production and its regulation, their conversions and routes of entry into the developing mammalian brain. The endocrine environment has to adjust when an embryo ceases to rely solely on maternal source of hormones as its own thyroid gland develops and starts to produce endogenous TH. A number of mechanisms are in place to secure the proper delivery and action of TH with placenta, blood-brain interface, and choroid plexus as barriers of entry that need to selectively transport and modify these hormones thus controlling their active levels. Additionally, target cells also possess mechanisms to import, modify and bind TH to further fine-tune their action. A complex picture of a tightly regulated network of transport proteins, modifying enzymes, and receptors has emerged from the past studies. TH have been implicated in multiple processes related to brain formation in mammals-neuronal progenitor proliferation, neuronal migration, functional maturation, and survival-with their exact roles changing over developmental time. Given the plethora of effects thyroid hormones exert on various cell types at different developmental periods, the precise spatiotemporal regulation of their action is of crucial importance. In this review we summarize the current knowledge about TH delivery, conversions, and function in the developing mammalian brain. We also discuss their potential role in vertebrate brain evolution and offer future directions for research aimed at elucidating TH signaling in nervous system development." @default.
• W2934548328 created "2019-04-11" @default.
• W2934548328 creator A5027036729 @default.
• W2934548328 creator A5027836293 @default.
• W2934548328 date "2019-04-03" @default.
• W2934548328 modified "2023-10-14" @default.
• W2934548328 title "Transport, Metabolism, and Function of Thyroid Hormones in the Developing Mammalian Brain" @default.
• W2934548328 cites W1453753632 @default.
• W2934548328 cites W1485759788 @default.
• W2934548328 cites W1504779556 @default.
• W2934548328 cites W1509319711 @default.
• W2934548328 cites W1554160015 @default.
• W2934548328 cites W1573386528 @default.
• W2934548328 cites W157424974 @default.
• W2934548328 cites W1587621508 @default.
• W2934548328 cites W1592115964 @default.
• W2934548328 cites W1757132757 @default.
• W2934548328 cites W1823551867 @default.
• W2934548328 cites W1882050418 @default.
• W2934548328 cites W1915498945 @default.
• W2934548328 cites W1926332751 @default.
• W2934548328 cites W1964735900 @default.
• W2934548328 cites W1965357288 @default.
• W2934548328 cites W1965462646 @default.
• W2934548328 cites W1965743926 @default.
• W2934548328 cites W1966123992 @default.
• W2934548328 cites W1966895214 @default.
• W2934548328 cites W1969019749 @default.
• W2934548328 cites W1969520586 @default.
• W2934548328 cites W1971359230 @default.
• W2934548328 cites W1972866559 @default.
• W2934548328 cites W1972994957 @default.
• W2934548328 cites W1973481375 @default.
• W2934548328 cites W1974469329 @default.
• W2934548328 cites W1974491838 @default.
• W2934548328 cites W1975345061 @default.
• W2934548328 cites W1975956491 @default.
• W2934548328 cites W1976648095 @default.
• W2934548328 cites W1976707420 @default.
• W2934548328 cites W1977665604 @default.
• W2934548328 cites W1977680584 @default.
• W2934548328 cites W1978078295 @default.
• W2934548328 cites W1979697072 @default.
• W2934548328 cites W1980276940 @default.
• W2934548328 cites W1981041844 @default.
• W2934548328 cites W1981518456 @default.
• W2934548328 cites W1983592226 @default.
• W2934548328 cites W1983834103 @default.
• W2934548328 cites W1985865142 @default.
• W2934548328 cites W1985911270 @default.
• W2934548328 cites W1987475341 @default.
• W2934548328 cites W1988348937 @default.
• W2934548328 cites W1988405671 @default.
• W2934548328 cites W1988629919 @default.
• W2934548328 cites W1988982593 @default.
• W2934548328 cites W1989440914 @default.
• W2934548328 cites W1989474078 @default.
• W2934548328 cites W1989898590 @default.
• W2934548328 cites W1990329100 @default.
• W2934548328 cites W1990498832 @default.
• W2934548328 cites W1991454487 @default.
• W2934548328 cites W1991545787 @default.
• W2934548328 cites W1992100370 @default.
• W2934548328 cites W1992268803 @default.
• W2934548328 cites W1993119799 @default.
• W2934548328 cites W1993158686 @default.
• W2934548328 cites W1994426399 @default.
• W2934548328 cites W1994869560 @default.
• W2934548328 cites W1995656567 @default.
• W2934548328 cites W1996321551 @default.
• W2934548328 cites W1996499858 @default.
• W2934548328 cites W2000345419 @default.
• W2934548328 cites W2000741536 @default.
• W2934548328 cites W2001411873 @default.
• W2934548328 cites W2002154622 @default.
• W2934548328 cites W2002197081 @default.
• W2934548328 cites W2002311807 @default.
• W2934548328 cites W2002669455 @default.
• W2934548328 cites W2003054045 @default.
• W2934548328 cites W2003795436 @default.
• W2934548328 cites W2004471830 @default.
• W2934548328 cites W2006197047 @default.
• W2934548328 cites W2006418305 @default.
• W2934548328 cites W2007210421 @default.
• W2934548328 cites W2008077160 @default.
• W2934548328 cites W2008675470 @default.
• W2934548328 cites W2015843695 @default.
• W2934548328 cites W2017632004 @default.
• W2934548328 cites W2018045327 @default.
• W2934548328 cites W2018379901 @default.
• W2934548328 cites W2019116187 @default.
• W2934548328 cites W2021932599 @default.
• W2934548328 cites W2022426475 @default.
• W2934548328 cites W2022762329 @default.
• W2934548328 cites W2023056664 @default.
• W2934548328 cites W2024033226 @default.
• W2934548328 cites W2024116370 @default.
• W2934548328 cites W2024292910 @default.
• W2934548328 cites W2024600112 @default.
• W2934548328 cites W2024987883 @default.

• next