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• W2934607539 abstract "Viral protein 2C plays a critical role in EV-A71 replication. The discovery of 2C binding proteins will likely provide potential targets to treat EV-A71 infection. Here, we provide a global proteomic analysis of the human proteins that interact with the EV-A71 2C protein. TRIM4, exportin2, and ARFGAP1 were validated as 2C binding partners. Further functional studies revealed that TRIM4, exportin2, and ARFGAP1 were novel host dependency factors for EV-A71. Moreover, enteroviruses' 2C family proteins interacted with exportin2 and ARFGAP1. In conclusion, our study provides a cellular interactome of the EV-A71 2C and identifies the proviral roles of TRIM4, exportin2, and ARFGAP1 in EV-A71 infection." @default.
• W2934607539 created "2019-04-11" @default.
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• W2934607539 date "2019-04-02" @default.
• W2934607539 modified "2023-10-03" @default.
• W2934607539 title "Elucidating the Host Interactome of EV-A71 2C Reveals Viral Dependency Factors" @default.
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• W2934607539 doi "https://doi.org/10.3389/fmicb.2019.00636" @default.
• W2934607539 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6454016" @default.
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