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• W2934716754 abstract "We present cisTopic, a probabilistic framework used to simultaneously discover coaccessible enhancers and stable cell states from sparse single-cell epigenomics data ( http://github.com/aertslab/cistopic ). Using a compendium of single-cell ATAC-seq datasets from differentiating hematopoietic cells, brain and transcription factor perturbations, we demonstrate that topic modeling can be exploited for robust identification of cell types, enhancers and relevant transcription factors. cisTopic provides insight into the mechanisms underlying regulatory heterogeneity in cell populations." @default.
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• W2934716754 date "2019-04-08" @default.
• W2934716754 modified "2023-10-17" @default.
• W2934716754 title "cisTopic: cis-regulatory topic modeling on single-cell ATAC-seq data" @default.
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• W2934716754 doi "https://doi.org/10.1038/s41592-019-0367-1" @default.
• W2934716754 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6517279" @default.
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