Matches in SemOpenAlex for { <https://semopenalex.org/work/W293471811> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W293471811 endingPage "13474" @default.
- W293471811 startingPage "13468" @default.
- W293471811 abstract "Human lymphocytes respond optimally to mitogenic stimulation when cultured in serum-free medium supplemented with transferrin if fatty acids necessary for maximal proliferation are provided. Either lipoproteins or exogenous fatty acids support optimal lymphocyte responses. The current studies examined the role of cell surface receptors for low density lipoprotein (LDL) in the enhancement of lymphocyte proliferation. Support of lymphocyte growth by limiting concentrations of LDL was found to involve interaction of the lipoprotein with LDL receptors. Thus, modification of LDL by reductive methylation so as to inhibit receptor-mediated interactions markedly decreased the capacity of LDL to enhance lymphocyte proliferation. Moreover, growth of lymphocytes obtained from patients with LDL receptor-negative homozygous familial hypercholesterolemia was minimal when cultures were supplemented with low concentrations of LDL (less than 10 micrograms cholesterol/ml). LDL also enhanced lymphocyte proliferation by a receptor-independent mechanism since high concentrations (greater than or equal to 50 micrograms cholesterol/ml) supported growth of both normal and familial hypercholesterolemia lymphocytes. In contrast, support of lymphocyte proliferation by high density lipoprotein (HDL) subclass 3 was completely independent of LDL receptors. Thus, HDL3 enhanced responses of both normal and familial hypercholesterolemia lymphocytes in an equivalent concentration-dependent manner; this effect was not altered by reductive methylation of HDL3. One function of lipoproteins in this system may be the provision of fatty acids since oleic and linoleic acids enhanced DNA synthesis by both normal and familial hypercholesterolemia lymphocytes in the absence of lipoproteins. These results indicate that lipoproteins may provide fatty acids necessary for optimal proliferation of human lymphocytes by both LDL receptor-mediated and LDL receptor-independent interactions." @default.
- W293471811 created "2016-06-24" @default.
- W293471811 creator A5007342242 @default.
- W293471811 creator A5043874873 @default.
- W293471811 date "1989-08-01" @default.
- W293471811 modified "2023-10-14" @default.
- W293471811 title "Lipoproteins May Provide Fatty Acids Necessary for Human Lymphocyte Proliferation by Both Low Density Lipoprotein Receptor-dependent and -independent Mechanisms" @default.
- W293471811 cites W1486963290 @default.
- W293471811 cites W1487164341 @default.
- W293471811 cites W1487727195 @default.
- W293471811 cites W1575378193 @default.
- W293471811 cites W1581616514 @default.
- W293471811 cites W1631424226 @default.
- W293471811 cites W1966370012 @default.
- W293471811 cites W1969068329 @default.
- W293471811 cites W1972968384 @default.
- W293471811 cites W1974182547 @default.
- W293471811 cites W2004359169 @default.
- W293471811 cites W2017640755 @default.
- W293471811 cites W2029481246 @default.
- W293471811 cites W2052914922 @default.
- W293471811 cites W2065956596 @default.
- W293471811 cites W2084744450 @default.
- W293471811 cites W2088577558 @default.
- W293471811 cites W2111433219 @default.
- W293471811 cites W2121767872 @default.
- W293471811 cites W2156799866 @default.
- W293471811 cites W2157490439 @default.
- W293471811 cites W2177552011 @default.
- W293471811 cites W2183256872 @default.
- W293471811 cites W2336778665 @default.
- W293471811 cites W2341410391 @default.
- W293471811 doi "https://doi.org/10.1016/s0021-9258(18)80020-5" @default.
- W293471811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2760030" @default.
- W293471811 hasPublicationYear "1989" @default.
- W293471811 type Work @default.
- W293471811 sameAs 293471811 @default.
- W293471811 citedByCount "39" @default.
- W293471811 countsByYear W2934718112015 @default.
- W293471811 countsByYear W2934718112016 @default.
- W293471811 countsByYear W2934718112021 @default.
- W293471811 countsByYear W2934718112022 @default.
- W293471811 crossrefType "journal-article" @default.
- W293471811 hasAuthorship W293471811A5007342242 @default.
- W293471811 hasAuthorship W293471811A5043874873 @default.
- W293471811 hasBestOaLocation W2934718111 @default.
- W293471811 hasConcept C170493617 @default.
- W293471811 hasConcept C185592680 @default.
- W293471811 hasConcept C203014093 @default.
- W293471811 hasConcept C2777761686 @default.
- W293471811 hasConcept C2778163477 @default.
- W293471811 hasConcept C2779620165 @default.
- W293471811 hasConcept C2780072125 @default.
- W293471811 hasConcept C55493867 @default.
- W293471811 hasConcept C86803240 @default.
- W293471811 hasConcept C95444343 @default.
- W293471811 hasConceptScore W293471811C170493617 @default.
- W293471811 hasConceptScore W293471811C185592680 @default.
- W293471811 hasConceptScore W293471811C203014093 @default.
- W293471811 hasConceptScore W293471811C2777761686 @default.
- W293471811 hasConceptScore W293471811C2778163477 @default.
- W293471811 hasConceptScore W293471811C2779620165 @default.
- W293471811 hasConceptScore W293471811C2780072125 @default.
- W293471811 hasConceptScore W293471811C55493867 @default.
- W293471811 hasConceptScore W293471811C86803240 @default.
- W293471811 hasConceptScore W293471811C95444343 @default.
- W293471811 hasIssue "23" @default.
- W293471811 hasLocation W2934718111 @default.
- W293471811 hasOpenAccess W293471811 @default.
- W293471811 hasPrimaryLocation W2934718111 @default.
- W293471811 hasRelatedWork W1812963099 @default.
- W293471811 hasRelatedWork W1964777313 @default.
- W293471811 hasRelatedWork W1965267801 @default.
- W293471811 hasRelatedWork W2001938441 @default.
- W293471811 hasRelatedWork W2059714760 @default.
- W293471811 hasRelatedWork W2077160325 @default.
- W293471811 hasRelatedWork W2087652827 @default.
- W293471811 hasRelatedWork W2088132089 @default.
- W293471811 hasRelatedWork W2188273781 @default.
- W293471811 hasRelatedWork W2336778665 @default.
- W293471811 hasVolume "264" @default.
- W293471811 isParatext "false" @default.
- W293471811 isRetracted "false" @default.
- W293471811 magId "293471811" @default.
- W293471811 workType "article" @default.