FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2934725145> ?p ?o ?g. }

• W2934725145 abstract "Abstract Tradeoffs constrain the improvement of performance of multiple traits simultaneously. Such tradeoffs define Pareto fronts, which represent a set of optimal individuals that cannot be improved in any one trait without reducing performance in another. Surprisingly, experimental evolution often yields genotypes with improved performance in all measured traits, perhaps indicating an absence of tradeoffs at least in the short-term. Here we densely sample adaptive mutations in S. cerevisiae to ask whether first-step adaptive mutations result in tradeoffs during the growth cycle. We isolated thousands of adaptive clones evolved under carefully chosen conditions and quantified their performances in each part of the growth cycle. We too find that some first-step adaptive mutations can improve all traits to a modest extent. However, our dense sampling allowed us to identify tradeoffs and establish the existence of Pareto fronts between fermentation and respiration, and between respiration and stationary phases. Moreover, we establish that no single mutation in the ancestral genome can circumvent the detected tradeoffs. Finally, we sequenced hundreds of these adaptive clones, revealing novel targets of adaptation and defining the genetic basis of the identified tradeoffs." @default.
• W2934725145 created "2019-04-11" @default.
• W2934725145 creator A5027351735 @default.
• W2934725145 creator A5036472958 @default.
• W2934725145 creator A5058333700 @default.
• W2934725145 date "2019-03-30" @default.
• W2934725145 modified "2023-09-26" @default.
• W2934725145 title "Single Nucleotide Mapping of the Locally Accessible Trait Space in Yeast Reveals Pareto Fronts that Constrain Initial Adaptation" @default.
• W2934725145 cites W1602052219 @default.
• W2934725145 cites W1985561503 @default.
• W2934725145 cites W1994148031 @default.
• W2934725145 cites W1994213227 @default.
• W2934725145 cites W2010025771 @default.
• W2934725145 cites W2018826201 @default.
• W2934725145 cites W2025482826 @default.
• W2934725145 cites W2029365764 @default.
• W2934725145 cites W2038702371 @default.
• W2934725145 cites W2052811168 @default.
• W2934725145 cites W2061815181 @default.
• W2934725145 cites W2068074687 @default.
• W2934725145 cites W2070735012 @default.
• W2934725145 cites W2095081307 @default.
• W2934725145 cites W2103916085 @default.
• W2934725145 cites W2106204214 @default.
• W2934725145 cites W2115555625 @default.
• W2934725145 cites W2124643297 @default.
• W2934725145 cites W2144532121 @default.
• W2934725145 cites W2154256638 @default.
• W2934725145 cites W2172985714 @default.
• W2934725145 cites W2402939098 @default.
• W2934725145 cites W2518349977 @default.
• W2934725145 cites W2527870842 @default.
• W2934725145 cites W2561067972 @default.
• W2934725145 cites W2562422532 @default.
• W2934725145 cites W2580945124 @default.
• W2934725145 cites W2756993043 @default.
• W2934725145 cites W2787639678 @default.
• W2934725145 cites W2898676982 @default.
• W2934725145 cites W394507619 @default.
• W2934725145 cites W4234420637 @default.
• W2934725145 cites W4243390718 @default.
• W2934725145 doi "https://doi.org/10.1101/593947" @default.
• W2934725145 hasPublicationYear "2019" @default.
• W2934725145 type Work @default.
• W2934725145 sameAs 2934725145 @default.
• W2934725145 citedByCount "1" @default.
• W2934725145 countsByYear W29347251452019 @default.
• W2934725145 crossrefType "posted-content" @default.
• W2934725145 hasAuthorship W2934725145A5027351735 @default.
• W2934725145 hasAuthorship W2934725145A5036472958 @default.
• W2934725145 hasAuthorship W2934725145A5058333700 @default.
• W2934725145 hasBestOaLocation W29347251451 @default.
• W2934725145 hasConcept C106934330 @default.
• W2934725145 hasConcept C126255220 @default.
• W2934725145 hasConcept C137635306 @default.
• W2934725145 hasConcept C139807058 @default.
• W2934725145 hasConcept C169760540 @default.
• W2934725145 hasConcept C177264268 @default.
• W2934725145 hasConcept C199360897 @default.
• W2934725145 hasConcept C2986314615 @default.
• W2934725145 hasConcept C33923547 @default.
• W2934725145 hasConcept C41008148 @default.
• W2934725145 hasConcept C54355233 @default.
• W2934725145 hasConcept C70721500 @default.
• W2934725145 hasConcept C78458016 @default.
• W2934725145 hasConcept C86803240 @default.
• W2934725145 hasConceptScore W2934725145C106934330 @default.
• W2934725145 hasConceptScore W2934725145C126255220 @default.
• W2934725145 hasConceptScore W2934725145C137635306 @default.
• W2934725145 hasConceptScore W2934725145C139807058 @default.
• W2934725145 hasConceptScore W2934725145C169760540 @default.
• W2934725145 hasConceptScore W2934725145C177264268 @default.
• W2934725145 hasConceptScore W2934725145C199360897 @default.
• W2934725145 hasConceptScore W2934725145C2986314615 @default.
• W2934725145 hasConceptScore W2934725145C33923547 @default.
• W2934725145 hasConceptScore W2934725145C41008148 @default.
• W2934725145 hasConceptScore W2934725145C54355233 @default.
• W2934725145 hasConceptScore W2934725145C70721500 @default.
• W2934725145 hasConceptScore W2934725145C78458016 @default.
• W2934725145 hasConceptScore W2934725145C86803240 @default.
• W2934725145 hasLocation W29347251451 @default.
• W2934725145 hasOpenAccess W2934725145 @default.
• W2934725145 hasPrimaryLocation W29347251451 @default.
• W2934725145 hasRelatedWork W1684052628 @default.
• W2934725145 hasRelatedWork W1806649701 @default.
• W2934725145 hasRelatedWork W2165327448 @default.
• W2934725145 hasRelatedWork W2228169868 @default.
• W2934725145 hasRelatedWork W2525959361 @default.
• W2934725145 hasRelatedWork W2530587419 @default.
• W2934725145 hasRelatedWork W2547332371 @default.
• W2934725145 hasRelatedWork W2787661251 @default.
• W2934725145 hasRelatedWork W2947312596 @default.
• W2934725145 hasRelatedWork W2949229445 @default.
• W2934725145 hasRelatedWork W2949278254 @default.
• W2934725145 hasRelatedWork W2950313884 @default.
• W2934725145 hasRelatedWork W2951016035 @default.
• W2934725145 hasRelatedWork W2952742538 @default.
• W2934725145 hasRelatedWork W2979866905 @default.
• W2934725145 hasRelatedWork W3083410417 @default.
• W2934725145 hasRelatedWork W3097193002 @default.

• next