Matches in SemOpenAlex for { <https://semopenalex.org/work/W2934809750> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2934809750 abstract "Abstract Plasmids are found across bacteria, archaea, and eukaryotes and play an important role in evolution. Plasmids exist at different copy numbers, the number of copies of the plasmid per cell, ranging from a single plasmid per cell to hundreds of plasmids per cell. This feature of a copy number greater than one can lead to a population of plasmids within a single cell that are not identical clones of one another, but rather have individual mutations that make a given plasmid unique. During cell division, this population of plasmids is partitioned into the two daughter cells, resulting in a random distribution of different plasmid variants in each daughter. In this study, we use stochastic simulations to investigate how random plasmid partitioning compares to a perfect partitioning model. Our simulation results demonstrate that random plasmid partitioning accelerates mutant allele fixation when the allele is beneficial and the selection is in an additive or recessive regime where increasing the copy number of the beneficial allele results in additional benefit for the host. This effect does not depend on the size of the benefit conferred or the mutation rate, but is magnified by increasing plasmid copy number." @default.
- W2934809750 created "2019-04-11" @default.
- W2934809750 creator A5001450823 @default.
- W2934809750 creator A5079254335 @default.
- W2934809750 creator A5080865669 @default.
- W2934809750 date "2019-03-31" @default.
- W2934809750 modified "2023-10-01" @default.
- W2934809750 title "Quantitative characterization of random partitioning in the evolution of plasmid-encoded traits" @default.
- W2934809750 cites W1952802364 @default.
- W2934809750 cites W1964072345 @default.
- W2934809750 cites W1973964227 @default.
- W2934809750 cites W1985161570 @default.
- W2934809750 cites W2006478187 @default.
- W2934809750 cites W2010698950 @default.
- W2934809750 cites W2011301426 @default.
- W2934809750 cites W2024622044 @default.
- W2934809750 cites W2027463558 @default.
- W2934809750 cites W2035187003 @default.
- W2934809750 cites W2039940889 @default.
- W2934809750 cites W2058124388 @default.
- W2934809750 cites W2075886697 @default.
- W2934809750 cites W2094308587 @default.
- W2934809750 cites W2146292423 @default.
- W2934809750 cites W2155418451 @default.
- W2934809750 cites W2245493112 @default.
- W2934809750 cites W2317656203 @default.
- W2934809750 cites W2548959205 @default.
- W2934809750 cites W2773986619 @default.
- W2934809750 cites W2788004430 @default.
- W2934809750 cites W2884862299 @default.
- W2934809750 cites W4210990206 @default.
- W2934809750 doi "https://doi.org/10.1101/594879" @default.
- W2934809750 hasPublicationYear "2019" @default.
- W2934809750 type Work @default.
- W2934809750 sameAs 2934809750 @default.
- W2934809750 citedByCount "9" @default.
- W2934809750 countsByYear W29348097502019 @default.
- W2934809750 countsByYear W29348097502021 @default.
- W2934809750 countsByYear W29348097502022 @default.
- W2934809750 countsByYear W29348097502023 @default.
- W2934809750 crossrefType "posted-content" @default.
- W2934809750 hasAuthorship W2934809750A5001450823 @default.
- W2934809750 hasAuthorship W2934809750A5079254335 @default.
- W2934809750 hasAuthorship W2934809750A5080865669 @default.
- W2934809750 hasBestOaLocation W29348097501 @default.
- W2934809750 hasConcept C104317684 @default.
- W2934809750 hasConcept C143065580 @default.
- W2934809750 hasConcept C144024400 @default.
- W2934809750 hasConcept C1491633281 @default.
- W2934809750 hasConcept C149923435 @default.
- W2934809750 hasConcept C180754005 @default.
- W2934809750 hasConcept C22744801 @default.
- W2934809750 hasConcept C2777116013 @default.
- W2934809750 hasConcept C2908647359 @default.
- W2934809750 hasConcept C54355233 @default.
- W2934809750 hasConcept C552990157 @default.
- W2934809750 hasConcept C85813293 @default.
- W2934809750 hasConcept C86803240 @default.
- W2934809750 hasConceptScore W2934809750C104317684 @default.
- W2934809750 hasConceptScore W2934809750C143065580 @default.
- W2934809750 hasConceptScore W2934809750C144024400 @default.
- W2934809750 hasConceptScore W2934809750C1491633281 @default.
- W2934809750 hasConceptScore W2934809750C149923435 @default.
- W2934809750 hasConceptScore W2934809750C180754005 @default.
- W2934809750 hasConceptScore W2934809750C22744801 @default.
- W2934809750 hasConceptScore W2934809750C2777116013 @default.
- W2934809750 hasConceptScore W2934809750C2908647359 @default.
- W2934809750 hasConceptScore W2934809750C54355233 @default.
- W2934809750 hasConceptScore W2934809750C552990157 @default.
- W2934809750 hasConceptScore W2934809750C85813293 @default.
- W2934809750 hasConceptScore W2934809750C86803240 @default.
- W2934809750 hasLocation W29348097501 @default.
- W2934809750 hasLocation W29348097502 @default.
- W2934809750 hasOpenAccess W2934809750 @default.
- W2934809750 hasPrimaryLocation W29348097501 @default.
- W2934809750 hasRelatedWork W1571771606 @default.
- W2934809750 hasRelatedWork W1968976175 @default.
- W2934809750 hasRelatedWork W2032578176 @default.
- W2934809750 hasRelatedWork W2050897266 @default.
- W2934809750 hasRelatedWork W2091920404 @default.
- W2934809750 hasRelatedWork W2111958127 @default.
- W2934809750 hasRelatedWork W2223919059 @default.
- W2934809750 hasRelatedWork W2414030161 @default.
- W2934809750 hasRelatedWork W2524850911 @default.
- W2934809750 hasRelatedWork W3215086467 @default.
- W2934809750 isParatext "false" @default.
- W2934809750 isRetracted "false" @default.
- W2934809750 magId "2934809750" @default.
- W2934809750 workType "article" @default.